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Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Copyright (c) 2023 Oluwaseyefunmi Iyabo Adeniran, Lesibana Samuel Sethoga, Leshweni Jeremia Shai, Sechene Stanley Gololo

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Anti-glycation and phytochemical properties of cinnamon stem-bark water extract

https://doi.org/10.14233/ajchem.2023.28084
Oluwaseyefunmi Iyabo Adeniran
Department of Biochemistry and Biotechnology, Sefako Makgatho Health Sciences University, P.O. Box 235, Medunsa 0204, South Africa
https://orcid.org/0000-0002-5975-7943
Lesibana Samuel Sethoga
Department of Chemistry, Sefako Makgatho Health Sciences University, P.O. Box 235, Medunsa 0204, South Africa
https://orcid.org/0000-0003-0472-6549
Leshweni Jeremia Shai
Department of Biomedical Sciences, Tshwane University of Technology Arcadia, Pretoria, South Africa
https://orcid.org/0000-0003-4799-7437
Sechene Stanley Gololo
Department of Biochemistry and Biotechnology, Sefako Makgatho Health Sciences University, P.O. Box 235, Medunsa 0204, South Africa
https://orcid.org/0000-0002-8059-1941

Corresponding Author(s) : Oluwaseyefunmi Iyabo Adeniran

seyefunmiadeniran@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Abstract

The study evaluated the ability of cinnamon stem-bark water extract (CWE) to break established cross-links formed between proteins and advanced glycation end-products (AGEs) as well as its anti-glycation effect. The extract showed a dose-dependent anti-glycation effect against total fluorescent AGEs (FAGEs) derived from both glucose and fructose. CWE recorded a uniform IC50 value of 0.13 mg/mL for both glucose and fructose-derived FAGEs while aminoguanidine, a well-known synthetic anti-glycative agent gave IC50 values of 0.14 mg/mL for the glucose and 0.17 mg/mL for the fructose derived FAGEs. The anti-glycative effect of CWE was also significantly higher than aminoguanidine against total immunogenic AGE (TIAGEs) in both sugar models (p < 0.001). While CWE and aminoguanidine showed weak protein cross-link breaking activity selectively on fructose-derived protein cross-links already formed, none whatsoever was detected exerted on the established glucose-derived protein cross-links. Phytochemical screening revealed the presence of several important secondary metabolites which may have contributed to the anti-glycative effect of CWE. Gas chromatography mass spectrometry enabled the identification of (+)-alpha-tocopherol acetate, a chain breaker, in the methanol fraction of CWE. Although CWE showed great potential for inhibition of formation of major types of AGEs, it appears to be poor in breaking established cross-links formed between proteins and AGEs.     

Keywords

Cinnamon stem Anti-glycation Advanced glycation end-products (AGEs) Aminoguanidine Diabetes
Adeniran, O. I., Sethoga, L. S., Shai, L. J., & Gololo, S. S. (2023). Anti-glycation and phytochemical properties of cinnamon stem-bark water extract. Asian Journal of Chemistry, 35(9), 2235–2240. https://doi.org/10.14233/ajchem.2023.28084
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Author Biographies

Lesibana Samuel Sethoga, Department of Chemistry, Sefako Makgatho Health Sciences University, P.O. Box 235, Medunsa 0204, South Africa

Chemistry Department

Leshweni Jeremia Shai, Department of Biomedical Sciences, Tshwane University of Technology Arcadia, Pretoria, South Africa

Biomedical Sciences department

Sechene Stanley Gololo, Department of Biochemistry and Biotechnology, Sefako Makgatho Health Sciences University, P.O. Box 235, Medunsa 0204, South Africa

Biochemistry and Biotechnology department

Professor, Head of department

Statistic
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