Swelling Properties of Poly(N-isopropylacrylamide)/Calcium Alginate Interpenetrating Polymer Network Hydrogel containing Zirconia

Ing Hong Ooi; Shi Hui Ng; Yie Kie Chong; See Kiat Wong

doi:10.14233/ajchem.2015.19015

Issue

Vol. 27 No. 9 (2015): Vol 27 Issue 9

Issue Published : May 26, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Swelling Properties of Poly(N-isopropylacrylamide)/Calcium Alginate Interpenetrating Polymer Network Hydrogel containing Zirconia

https://doi.org/10.14233/ajchem.2015.19015

Ing Hong Ooi

Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia

Shi Hui Ng

Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia

Yie Kie Chong

Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia

See Kiat Wong

Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia

Corresponding Author(s) : Ing Hong Ooi

inghong_ooi@imu.edu.my

Asian Journal of Chemistry, Vol. 27 No. 9 (2015): Vol 27 Issue 9
Article Published : May 26, 2015

Abstract

Temperature-responsive poly(N-isopropylacrylamide)/calcium alginate interpenetrating polymer network hydrogels contaning different percentages of zirconia were prepared and evaluated for their swelling properties. The pore size of the interpenetrating polymer network hydrogels decreased with increasing content of zirconia. Incorporation of zirconia into the interpenetrating polymer network hydrogel decreased its ability to swell at temperatures below its lower critical solution temperature but resulted in larger shrinkages at temperatures above its lower critical solution temperature. The swelling-deswelling behaviour of the interpenetrating polymer network hydrogels between 25 °C and 37 °C was, however, rapid, responsive and reproducible.

Keywords

Poly(N-isopropylacrylamide)/Calcium alginate Hydrogel Zirconia Swelling ratio Interpenetrating polymer network

Hong Ooi, I., Hui Ng, S., Kie Chong, Y., & Kiat Wong, S. (2015). Swelling Properties of Poly(N-isopropylacrylamide)/Calcium Alginate Interpenetrating Polymer Network Hydrogel containing Zirconia. Asian Journal of Chemistry, 27(9), 3489–3493. https://doi.org/10.14233/ajchem.2015.19015

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L. He, Q. Zuo, S. Xie, Y. Huang and W. Xue, Recent Pat. Drug Deliv. Formul., 5, 265 (2011); doi:10.2174/187221111797200533.

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L. Klouda and A.G. Mikos, Eur. J. Pharm. Biopharm., 68, 34 (2008); doi:10.1016/j.ejpb.2007.02.025.

K.B. Doorty, T.A. Golubeva, A.V. Gorelov, Y.A. Rochev, L.T. Allen, K.A. Dawson, W.M. Gallagher and A.K. Keenan, Cardiovasc. Pathol., 12, 105 (2003); doi:10.1016/S1054-8807(02)00165-5.

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A. Galperin, T.J. Long and B.D. Ratner, Biomacromolecules, 11, 2583 (2010); doi:10.1021/bm100521x.

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T. Serizawa, K. Wakita, T. Kaneko and M. Akashi, J. Polym. Sci. A Polym. Chem., 40, 4228 (2002); doi:10.1002/pola.10482.

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X.Z. Zhang, Y.Y. Yang and T.S. Chung, Langmuir, 18, 2538 (2002); doi:10.1021/la011410j.

A.S. Hoffman, Adv. Drug Deliv. Rev., 64(S), 18 (2012); doi:10.1016/j.addr.2012.09.010.

Issue

Vol. 27 No. 9 (2015): Vol 27 Issue 9

Swelling Properties of Poly(N-isopropylacrylamide)/Calcium Alginate Interpenetrating Polymer Network Hydrogel containing Zirconia

Corresponding Author(s) : Ing Hong Ooi

Abstract

Keywords

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