Synthesis and Antibacterial Activity of Zn(II) Schiff Base Complexes Derived from 3-Acetyl-2H-chromen-2-one

Habib Hussain; Syeda Rubina Gilani; Farkhanda Jabeen; Zulfiqar Ali; Hajira Rehman; Imdad Hussain

doi:10.14233/ajchem.2015.18720

Issue

Vol. 27 No. 9 (2015): Vol 27 Issue 9

Issue Published : May 26, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Antibacterial Activity of Zn(II) Schiff Base Complexes Derived from 3-Acetyl-2H-chromen-2-one

https://doi.org/10.14233/ajchem.2015.18720

Habib Hussain

Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan

Syeda Rubina Gilani

Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan

Farkhanda Jabeen

Department of Botany, University of Punjab, Lahore, Pakistan

Zulfiqar Ali

Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan

Hajira Rehman

Department of Chemistry, University of Punjab, Lahore, Pakistan

Imdad Hussain

Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan

Corresponding Author(s) : Habib Hussain

hbubak@gmail.com

Asian Journal of Chemistry, Vol. 27 No. 9 (2015): Vol 27 Issue 9
Article Published : May 26, 2015

Abstract

Zn(II) Schiff base complexes viz., bis[(E)-3-(1-(p-tolylimino)ethyl)-2H-chromen-2-one]zinc(II), bis[(E)-3-(1-((4-chlorophenyl)-imino)ethyl)-2H-chromen-2-one]zinc(II) and bis[(E)-3-(1-((2- nitrophenyl)imino)-ethyl)-2H-chromen-2-one]zinc(II) derived from 3-acetyl-2H-chromen-2-one and p-toluidine, p-chloro aniline and 2-nitroaniline, respectively, have been synthesized and characterized. Physical properties like, infrared spectroscopy and l_max are recorded and presence of metal is confirmed by atomic absorption spectroscopy. Infrared spectra reveal complex formation of Zn(II) with synthesized ligands. Both free Schiff bases and their Zn(II) complexes have been screened for antibacterial activity against Gram-positive Bacillus subtilis, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative E. coli, P. aeruginosa, S. typhi by Agar plate diffusion method. All Schiff bases and their metal complexes appeared promising as antibacterial agents. Minimum inhibition concentrations were determined for each bacterial strain.

Keywords

Zn(II) complexes 3-Acetyl-2H-chromen-2-one p-Toluidine p-Chloroaniline 2-Nitroaniline Antibacterial activity

Hussain, H., Rubina Gilani, S., Jabeen, F., Ali, Z., Rehman, H., & Hussain, I. (2015). Synthesis and Antibacterial Activity of Zn(II) Schiff Base Complexes Derived from 3-Acetyl-2H-chromen-2-one. Asian Journal of Chemistry, 27(9), 3440–3444. https://doi.org/10.14233/ajchem.2015.18720

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L. Cheng, J. Tang, H. Luo, X. Jin, F. Dai, J. Yang, Y. Qian, X. Li and B. Zhou, Bioorg. Med. Chem. Lett., 20, 2417 (2010); doi:10.1016/j.bmcl.2010.03.039.

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Dorlands Medical Dictionary: Antibiotic; Archived from the Original On 2010-11-17; Retrieved 2010-10-29 (2010).

I.M. Mustafa, M.A. Hapipah, M.A. Abdulla and T.R. Ward, Polyhedron, 28, 3993 (2009); doi:10.1016/j.poly.2009.10.004.

G. Ciciani, M. Coronnello, G. Guerrini, S. Selleri, M. Cantore, P. Failli, E. Mini and A. Costanzo, Bioorg. Med. Chem., 16, 9409 (2008); doi:10.1016/j.bmc.2008.09.055.

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S.N. Pandeya, D. Sriram, G. Nath and E. DeClercq, Eur. J. Pharm. Sci., 9, 25 (1999); doi:10.1016/S0928-0987(99)00038-X.

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J. Tuite, Plant Pathological Methods, Fungi and Bacteria; Burgess Publishing Company: Minneapolis, MN, USA, p. 93 (1969).

Issue

Vol. 27 No. 9 (2015): Vol 27 Issue 9

Synthesis and Antibacterial Activity of Zn(II) Schiff Base Complexes Derived from 3-Acetyl-2H-chromen-2-one

Corresponding Author(s) : Habib Hussain

Abstract

Keywords

Full Article

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