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Synthesis, Molecular Structure and Antibacterial Activity of Spiro[2,2']indane-1',3'-dione-3-(o-chloro)phenyl-4-nitro Pyrrolizidine
Corresponding Author(s) : Guo-Xin Sun
Asian Journal of Chemistry,
Vol. 27 No. 9 (2015): Vol 27 Issue 9
Abstract
Spiro[2,2']indane-1',3'-dione-3-(o-chloro)phenyl-4-nitro pyrrolizidine was synthesized by 1,3-dipolar cycloaddition reaction. It was characterized by NMR, MS and single-crystal X-ray diffraction. It crystallizes in the triclinic space group, P-1, with unit cell dimensions a = 7.6074(4) Å, b = 9.7454(5) Å and c = 12.6538(7) Å, a = 85.313(2)º, b = 84.217(2)º, g = 86.571(2)º and Z = 2. It was screened for antibacterial activity against oilfield water-borne bacteria and it showed good to moderate activity against sulfate reducing bacteria.
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- S. Rehn, J. Bergman and B. Stensland, Eur. J. Org. Chem., 413 (2004); doi:10.1002/ejoc.200300621.
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References
S. Rehn, J. Bergman and B. Stensland, Eur. J. Org. Chem., 413 (2004); doi:10.1002/ejoc.200300621.
G. Chen, H.P. He, J. Ding and X.J. Hao, Heterocycl. Commun., 15, 355 (2009); doi:10.1515/HC.2009.15.5.355.
T. Okino, Y. Hoashi, T. Furukawa, X. Xu and Y. Takemoto, J. Am. Chem. Soc., 127, 119 (2005); doi:10.1021/ja044370p.
A.A. Raj, R. Raghunathan, M.R. Sridevi Kumari and N. Raman, Bioorg. Med. Chem., 11, 407 (2003); doi:10.1016/S0968-0896(02)00439-X.
G.M. Sheldrick, SADABS. Version 2.10, University of Gottingen, Germany (2003).
Z. Otwinowski and W. Minor, in eds.: C.W. Carter and R.M. Sweet, Methods in Enzymology, In: Part A, Macromolecular Crystallography, Academic Press, New York, Vol 276, pp 307-326 (1997).
G.M. Sheldrick, SHELXS97, University of Göttingen, Germany (1997).
G.M. Sheldrick, SHELXL97, University of Göttingen, Germany (1997).
C.K. Johnson, ORTEP II, Report ORNL-5136. Oak Ridge National Laboratory, Oak Ridge (1976).
C. Impact DIAMOND, Version 3.1c, Crystal Impact GbR, Postfach, 1251, D-53002, Bonn, Germany (2006).