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Design, Synthesis and Pharmacological Properties of Peptidomimetics: A Review

https://doi.org/10.14233/ajchem.2015.18962
Ahmad Junaid
School of Postgraduate Studies, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia
Pran Kishore Deb
Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia
Ing Hong Ooi
Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia
Dina El-Rabie
School of Postgraduate Studies, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia
Faridah Olubunmi Shuaib
School of Postgraduate Studies, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia
Rajakumari Rajasingam
School of Postgraduate Studies, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia

Corresponding Author(s) : Ing Hong Ooi

inghong_ooi@imu.edu.my

Asian Journal of Chemistry, Vol. 27 No. 9 (2015): Vol 27 Issue 9

Abstract

Peptidomimetics represent a unique class of future therapeutics with many potential applications in modern medicine. By structurally and functionally mimicking the key characteristics of endogenous peptides, various structural variants of peptidomimetics are designed, synthesized and evaluated for numerous biological activities. Advances in the area of drug design through peptidomimetics have resulted in many therapeutically potential candidates in preclinical as well as clinical trials. This review covers the strategies for the design, syntheses and applications of peptidomimetics.

Keywords

Peptidomimetics Natural peptides
Junaid, A., Kishore Deb, P., Hong Ooi, I., El-Rabie, D., Olubunmi Shuaib, F., & Rajasingam, R. (2015). Design, Synthesis and Pharmacological Properties of Peptidomimetics: A Review. Asian Journal of Chemistry, 27(9), 3137–3142. https://doi.org/10.14233/ajchem.2015.18962
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