Copyright (c) 2015 AJC
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Analysis of Fluoroquinolones by Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry
Corresponding Author(s) : Jianhua Wang
Asian Journal of Chemistry,
Vol. 27 No. 6 (2015): Vol 27 Issue 6
Abstract
In order to analyze fragmentation behaviours of fluoroquinolones, five commercially fluoroquinolones were investigated systematically by electrospray ionization quadrupole time-of-flight tandem mass spectrometry (ESI-Q-TOF-MS/MS) in positive ion mode. In simple MS spectra, the predominant precursor ions [M + H]+ were observed for molecular mass information. MS/MS experiments of the precursor ions [M + H]+ were used for characteristic cleavage fragments analysis to achieve detailed structural information. ESI-Q-TOF-MS/MS has been proven to be a fast, effective and practical tool for the analysis of the fragmentation patterns of fluoroquinolones. It was found that major fragment ions were produced by the cleavage of C-N or C-C bonds of piperazine ring of fluoroquinolones.
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- Y. Xiao, H. Chang, A. Jia and J.Y. Hu, J. Chromatogr. A, 1214, 100 (2008); doi:10.1016/j.chroma.2008.10.090.
- M.P. Hermo, E. Nemutlu, S. Kir, D. Barrón and J. Barbosa, Anal. Chim. Acta, 613, 98 (2008); doi:10.1016/j.aca.2008.02.045.
- N. Dorival-García, A. Zafra-Gómez, S. Cantarero, A. Navalón and J.L. Vílchez, Microchem. J., 106, 323 (2013); doi:10.1016/j.microc.2012.09.002.
- F. Belal, A.A. Al-Majed and A.M. Al-Obaid, Talanta, 50, 765 (1999); doi:10.1016/S0039-9140(99)00139-3.
- H. Zhang, Y.P. Ren and X.L. Bao, J. Pharmaceut. Biomed., 49, 367 (2009); doi:10.1016/j.jpba.2008.10.043.
- G. van Vyncht, A. Jànosi, G. Bordin, B. Toussaint, G. Maghuin-Rogister, E. De Pauw and A.R. Rodriguez, J. Chromatogr. A, 952, 121 (2002); doi:10.1016/S0021-9673(02)00092-4.
- W.M.A. Niessen, J. Chromatogr. A, 812, 53 (1998); doi:10.1016/S0021-9673(98)00281-7.
- A. Foroumadi, S. Emami, S. Rajabalian, M. Badinloo, N. Mohammadhosseini and A. Shafiee, Biomed. Pharmacother., 63, 216 (2009); doi:10.1016/j.biopha.2008.01.016.
- M.L. Glówka, D. Martynowski, A. Olczak, J. Bojarska, M. Szczesio and K. Kozłowska, J. Mol. Struct., 658, 43 (2003); doi:10.1016/S0022-2860(03)00425-3.
- Y. Wang, K. Yu and S.H. Wang, Spectrochim. Acta A, 65, 159 (2006); doi:10.1016/j.saa.2005.09.043.
- M. Holcapek, L. Kolàrivà, A. Ruzicka, R. Jambor and P. Jandera, Anal. Chem., 78, 4210 (2006); doi:10.1021/ac060263x.
- S. Bogialli, G. D’Ascenzo, A. Di Corcia, A. Laganà and S. Nicolardi, Food Chem., 108, 354 (2008); doi:10.1016/j.foodchem.2007.10.044.
- M. Clemente, M.P. Hermo, D. Barrón and J. Barbosa, J. Chromatogr. A, 1135, 170 (2006); doi:10.1016/j.chroma.2006.09.041.
- N.V. Hoof, K.D. Wasch, L. Okerman, W. Reybroeck, S. Poelmans, H. Noppe and H.D. Brabander, Anal. Chim. Acta, 529, 265 (2005); doi:10.1016/j.aca.2004.07.055.
- M. Ståhlman, C.S. Ejsing, K. Tarasov, J. Perman, J. Borén and K. Ekroos, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 877, 2664 (2009); doi:10.1016/j.jchromb.2009.02.037.
- R.L. Sleighter and P.G. Hatcher, J. Mass Spectrom., 42, 559 (2007); doi:10.1002/jms.1221.
References
Y. Xiao, H. Chang, A. Jia and J.Y. Hu, J. Chromatogr. A, 1214, 100 (2008); doi:10.1016/j.chroma.2008.10.090.
M.P. Hermo, E. Nemutlu, S. Kir, D. Barrón and J. Barbosa, Anal. Chim. Acta, 613, 98 (2008); doi:10.1016/j.aca.2008.02.045.
N. Dorival-García, A. Zafra-Gómez, S. Cantarero, A. Navalón and J.L. Vílchez, Microchem. J., 106, 323 (2013); doi:10.1016/j.microc.2012.09.002.
F. Belal, A.A. Al-Majed and A.M. Al-Obaid, Talanta, 50, 765 (1999); doi:10.1016/S0039-9140(99)00139-3.
H. Zhang, Y.P. Ren and X.L. Bao, J. Pharmaceut. Biomed., 49, 367 (2009); doi:10.1016/j.jpba.2008.10.043.
G. van Vyncht, A. Jànosi, G. Bordin, B. Toussaint, G. Maghuin-Rogister, E. De Pauw and A.R. Rodriguez, J. Chromatogr. A, 952, 121 (2002); doi:10.1016/S0021-9673(02)00092-4.
W.M.A. Niessen, J. Chromatogr. A, 812, 53 (1998); doi:10.1016/S0021-9673(98)00281-7.
A. Foroumadi, S. Emami, S. Rajabalian, M. Badinloo, N. Mohammadhosseini and A. Shafiee, Biomed. Pharmacother., 63, 216 (2009); doi:10.1016/j.biopha.2008.01.016.
M.L. Glówka, D. Martynowski, A. Olczak, J. Bojarska, M. Szczesio and K. Kozłowska, J. Mol. Struct., 658, 43 (2003); doi:10.1016/S0022-2860(03)00425-3.
Y. Wang, K. Yu and S.H. Wang, Spectrochim. Acta A, 65, 159 (2006); doi:10.1016/j.saa.2005.09.043.
M. Holcapek, L. Kolàrivà, A. Ruzicka, R. Jambor and P. Jandera, Anal. Chem., 78, 4210 (2006); doi:10.1021/ac060263x.
S. Bogialli, G. D’Ascenzo, A. Di Corcia, A. Laganà and S. Nicolardi, Food Chem., 108, 354 (2008); doi:10.1016/j.foodchem.2007.10.044.
M. Clemente, M.P. Hermo, D. Barrón and J. Barbosa, J. Chromatogr. A, 1135, 170 (2006); doi:10.1016/j.chroma.2006.09.041.
N.V. Hoof, K.D. Wasch, L. Okerman, W. Reybroeck, S. Poelmans, H. Noppe and H.D. Brabander, Anal. Chim. Acta, 529, 265 (2005); doi:10.1016/j.aca.2004.07.055.
M. Ståhlman, C.S. Ejsing, K. Tarasov, J. Perman, J. Borén and K. Ekroos, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 877, 2664 (2009); doi:10.1016/j.jchromb.2009.02.037.
R.L. Sleighter and P.G. Hatcher, J. Mass Spectrom., 42, 559 (2007); doi:10.1002/jms.1221.