Preparation, Characterization and Evaluation of Dissolution and Taste Masked Enrofloxacin Formulations using Inclusion/Solid Dispersion/Ion-Exchange Resin Approach

Xiaohong Zhang; Xiaoling Feng; Jianhua Wang

doi:10.14233/ajchem.2015.17625

Issue

Vol. 27 No. 6 (2015): Vol 27 Issue 6

Issue Published : March 17, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Preparation, Characterization and Evaluation of Dissolution and Taste Masked Enrofloxacin Formulations using Inclusion/Solid Dispersion/Ion-Exchange Resin Approach

https://doi.org/10.14233/ajchem.2015.17625

Xiaohong Zhang

Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, P.R. China

Xiaoling Feng

Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, P.R. China

Jianhua Wang

Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, P.R. China

Corresponding Author(s) : Jianhua Wang

wjh@cqu.edu.cn, cqubio@hotmail.com, 20111902098@cqu.edu.cn

Asian Journal of Chemistry, Vol. 27 No. 6 (2015): Vol 27 Issue 6
Article Published : March 17, 2015

Abstract

In the present study, solid dispersion and ion-exchange resin techniques were widely used for improving drugs dissolution properties. Several techniques were used to analyze the properties of these enrofloxacin (ENR) formulations, using differential scanning calorimetry, X-ray diffraction, Fourier transform infrared, dissolution study and masking taste. The results obtained showed that the rate of dissolution of enrofloxacin was greatly improved when formulated in ENR/PVP K30 solid dispersion as compared with other formulations and pure enrofloxacin. Ion-exchange resin had the best effect on masking taste.

Keywords

Enrofloxacin Inclusion complex Solid dispersion Ion-exchange resin complex

Zhang, X., Feng, X., & Wang, J. (2015). Preparation, Characterization and Evaluation of Dissolution and Taste Masked Enrofloxacin Formulations using Inclusion/Solid Dispersion/Ion-Exchange Resin Approach. Asian Journal of Chemistry, 27(6), 1983–1990. https://doi.org/10.14233/ajchem.2015.17625

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References

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H. Al-Obaidi, M.J. Lawrence, S. Shah, H. Moghul, N. Al-Saden and F. Bari, Int. J. Pharm., 446, 100 (2013); doi:10.1016/j.ijpharm.2013.02.009.

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J.Y. Zheng and M.P. Keeney, Int. J. Pharm., 310, 118 (2006); doi:10.1016/j.ijpharm.2005.11.046.

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A.J. Song, J.H. Wang, C.D. Liu and L.H. Deng, Chin. Sci. Bull., 54, 13187 (2009); doi:10.1007/s11434-009-0262-8.

N. Sun, X. Wei, B. Wu, J. Chen, Y. Lu and W. Wu, Powder Technol., 182, 72 (2008); doi:10.1016/j.powtec.2007.05.029.

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T. Ozeki, H. Yuasa and Y. Kanaya, J. Control. Rel., 58, 87 (1999); doi:10.1016/S0168-3659(98)00145-X.

T. Ozeki, H. Yuasa and Y. Kanaya, Int. J. Pharm., 171, 123 (1998); doi:10.1016/S0378-5173(98)00159-8.

Issue

Vol. 27 No. 6 (2015): Vol 27 Issue 6

Preparation, Characterization and Evaluation of Dissolution and Taste Masked Enrofloxacin Formulations using Inclusion/Solid Dispersion/Ion-Exchange Resin Approach

Corresponding Author(s) : Jianhua Wang

Abstract

Keywords

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