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Synthesis of Novel Heterocyclic Compounds Containing 1,5-Benzodiazepine
Corresponding Author(s) : B.E. Missaoui
Asian Journal of Chemistry,
Vol. 27 No. 6 (2015): Vol 27 Issue 6
Abstract
The purpose of this work is the development of a synthetic pathway that allows access to heterocyclic compounds containing the 1,5-benzodiazepines. The dehydroacetic acid has been widely studied as a starting material for the synthesis of natural products that exhibit interesting pharmacological properties. In the present work, we describe an easy and cost effective access way to new products 1,5-benzodiazepines involving a pyranic residue. All synthesized products were subjected to IR, 1H NMR and mass spectra studies.
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- A.R. Katritzky, R. Abonia, B. Yang, M. Qi and B. Insuaty, Synthesis, 1487 (1998); doi:10.1055/s-1998-2165.
- Gh. Roman, E. Comanita, Acta Chim. Slov., 49, 575 (2002).
- G. De Sarro, A. Chimirri, A. De Sarro, R. Gitto, S. Grasso and M. Zappalà, Eur. J. Med. Chem., 30, 925 (1995); doi:10.1016/0223-5234(96)88311-5.
- K. Satyanarayan and M.N. Rao, Indian J. Pharm. Sci., 55, 230 (1993).
- H. Kato, M. Nishikawa, E. Koshinaka, Ger offen., 2,189 (1978).
- K.P. Jadhar and D.B. Ingled, Indian J. Pharm. Sci., 55, 230 (1993).
- M. Bourin, Pharmacocinétique des benzodiazépines, edn 2 (1989).
- B.N. Kolli, Doctoratés-Sciences, USTHB, Alger, Algeria (1982).
- H. Kato, M. Nishikawa and E. Koshinaka, Chem. Abstr., 88, 152675d (1978).
- G. De Sarro, A. Chimirri, A. De Sarro, R. Gitto, S. Grasso and M. Zappalà, Eur. J. Med. Chem., 30, 925 (1995); doi:10.1016/0223-5234(96)88311-5.
- K. Satyanarayan and M.N. Rao, Indian J. Pharm. Sci., 55, 230 (1993).
- K.P. Jadhar and D.B. Ingled, Indian J. Pharm. Sci., 55, 230 (1993).
References
A.R. Katritzky, R. Abonia, B. Yang, M. Qi and B. Insuaty, Synthesis, 1487 (1998); doi:10.1055/s-1998-2165.
Gh. Roman, E. Comanita, Acta Chim. Slov., 49, 575 (2002).
G. De Sarro, A. Chimirri, A. De Sarro, R. Gitto, S. Grasso and M. Zappalà, Eur. J. Med. Chem., 30, 925 (1995); doi:10.1016/0223-5234(96)88311-5.
K. Satyanarayan and M.N. Rao, Indian J. Pharm. Sci., 55, 230 (1993).
H. Kato, M. Nishikawa, E. Koshinaka, Ger offen., 2,189 (1978).
K.P. Jadhar and D.B. Ingled, Indian J. Pharm. Sci., 55, 230 (1993).
M. Bourin, Pharmacocinétique des benzodiazépines, edn 2 (1989).
B.N. Kolli, Doctoratés-Sciences, USTHB, Alger, Algeria (1982).
H. Kato, M. Nishikawa and E. Koshinaka, Chem. Abstr., 88, 152675d (1978).
G. De Sarro, A. Chimirri, A. De Sarro, R. Gitto, S. Grasso and M. Zappalà, Eur. J. Med. Chem., 30, 925 (1995); doi:10.1016/0223-5234(96)88311-5.
K. Satyanarayan and M.N. Rao, Indian J. Pharm. Sci., 55, 230 (1993).
K.P. Jadhar and D.B. Ingled, Indian J. Pharm. Sci., 55, 230 (1993).