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Comparative Analysis of Cefotaxime Sodium and Cefoperazone Sodium Drugs Activity and their Phytochemical Combinations Against Bacteria
Corresponding Author(s) : Rabia Rehman
Asian Journal of Chemistry,
Vol. 27 No. 5 (2015): Vol 27 Issue 5
Abstract
Among the emerging classes of antibiotics, Cephalosporins have been in lime light throughout the last decade. Consisting of many generations the cephalosporins are well known for their broad spectrum of activity against many gram positive and gram negative microorganisms, either used alone or in combination with other antibiotic classes. But the combination of two cephalosporins has never been checked yet. In this research work, two cephalosporins. Cefotaxime sodium and cefoperazone sodium were tested individually, in combination with each other and also in combination with honey against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Increase in activity of these drugs in combination was observed in case of Escherichia coli. Antagonistic effects were predominant in these drug combinations. However, the combination of drug with honey resulted in dominant additive effect.
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- B.C. Millar, J. Xu and J.E. Moor, Curr. Issues Mol. Biol., 9, 21 (2007).
- M. Millar, A. Philpott, M. Wilks, A. Whiley, S. Warwick, E. Hennessy, P. Coen, S. Kempley, F. Stacey and K. Costeloe, J. Clin. Microbiol., 46, 560 (2008); doi:10.1128/JCM.00832-07.
- M.A. Nicasio, J.L. Kuti and D.P. Nicolau, Pharmacotherap., 28, 235 (2008); doi:10.1592/phco.28.2.235.
- T.J. Kinsella, V.C. Colussi, N.L. Oleinick and C.H. Sibata, Expert Opin. Pharmacother., 2, 917 (2001); doi:10.1517/14656566.2.6.917.
- B.J. Barnett and D.S. Stephens, Med. Sci., 314, 245 (1997); doi:10.1097/00000441-199710000-00007.
- A.P. Zavascki, A.L. Barth, J.F. Fernandes, A.L. Moro, A.L. Goncalves and L.Z. Goldani, Crit. Care, 10, R114 (2006); doi:10.1186/cc5006.
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- C.P. Luck, H. Wenchel and J. Helbig, J. Clin. Microbiol., 36, 1160 (1998).
- L.S. Tzouvelekis, E. Tzelepl, E. Prinarakis, M. Gazouli, A. Katrahoura, P. Glakkoup, O. Paniara and N.J. Legakis, J. Clin. Microbiol., 36, 266 (1998).
- R. Ackroyd, C. Kelty, N. Brown and M. Reed, Photochem. Photobiol., 74, 656 (2001); doi:10.1562/0031-8655(2001)074<0656:THOPAP>2.0.CO;2.
- J. Odachi, E. Ishii, A. Fukumoto and M. Tanaka, Seikatsu Eisei, 3, 15 (1993).
- G.G.F. Nascimento, J. Locatelli, P.C. Freitas and G.L. Silva, Braz. J. Microbiol., 31, 247 (2000).
- M.L. Cohen, Science, 257, 1050 (1992); doi:10.1126/science.257.5073.1050.
- C. Urban, S. Segal-Maurer and J.J. Rahal, Clin. Infect. Dis., 36, 1268 (2003); doi:10.1086/374847.
- M.R. Prajapati and P.J. Vyas, Life Sci. Leaflets, 13, 443 (2011).
- A. Anantharaman, M.S. Rizvi and D. Sahal, Antimicrob. Agents Chemother., 54, 1693 (2010); doi:10.1128/AAC.01231-09.
- C. Vidaillac, S.N. Leonard, H.S. Sader, R.N. Jones and M.J. Rybak, Antimicrob. Agents Chemother., 53, 2360 (2009); doi:10.1128/AAC.01452-08.
References
B.C. Millar, J. Xu and J.E. Moor, Curr. Issues Mol. Biol., 9, 21 (2007).
M. Millar, A. Philpott, M. Wilks, A. Whiley, S. Warwick, E. Hennessy, P. Coen, S. Kempley, F. Stacey and K. Costeloe, J. Clin. Microbiol., 46, 560 (2008); doi:10.1128/JCM.00832-07.
M.A. Nicasio, J.L. Kuti and D.P. Nicolau, Pharmacotherap., 28, 235 (2008); doi:10.1592/phco.28.2.235.
T.J. Kinsella, V.C. Colussi, N.L. Oleinick and C.H. Sibata, Expert Opin. Pharmacother., 2, 917 (2001); doi:10.1517/14656566.2.6.917.
B.J. Barnett and D.S. Stephens, Med. Sci., 314, 245 (1997); doi:10.1097/00000441-199710000-00007.
A.P. Zavascki, A.L. Barth, J.F. Fernandes, A.L. Moro, A.L. Goncalves and L.Z. Goldani, Crit. Care, 10, R114 (2006); doi:10.1186/cc5006.
L.B. Rice, Clin. Infect. Dis., 43(Suppl. 2), S100 (2006); doi:10.1086/504487.
C.P. Luck, H. Wenchel and J. Helbig, J. Clin. Microbiol., 36, 1160 (1998).
L.S. Tzouvelekis, E. Tzelepl, E. Prinarakis, M. Gazouli, A. Katrahoura, P. Glakkoup, O. Paniara and N.J. Legakis, J. Clin. Microbiol., 36, 266 (1998).
R. Ackroyd, C. Kelty, N. Brown and M. Reed, Photochem. Photobiol., 74, 656 (2001); doi:10.1562/0031-8655(2001)074<0656:THOPAP>2.0.CO;2.
J. Odachi, E. Ishii, A. Fukumoto and M. Tanaka, Seikatsu Eisei, 3, 15 (1993).
G.G.F. Nascimento, J. Locatelli, P.C. Freitas and G.L. Silva, Braz. J. Microbiol., 31, 247 (2000).
M.L. Cohen, Science, 257, 1050 (1992); doi:10.1126/science.257.5073.1050.
C. Urban, S. Segal-Maurer and J.J. Rahal, Clin. Infect. Dis., 36, 1268 (2003); doi:10.1086/374847.
M.R. Prajapati and P.J. Vyas, Life Sci. Leaflets, 13, 443 (2011).
A. Anantharaman, M.S. Rizvi and D. Sahal, Antimicrob. Agents Chemother., 54, 1693 (2010); doi:10.1128/AAC.01231-09.
C. Vidaillac, S.N. Leonard, H.S. Sader, R.N. Jones and M.J. Rybak, Antimicrob. Agents Chemother., 53, 2360 (2009); doi:10.1128/AAC.01452-08.