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Vol. 27 No. 2 (2015): Vol 27 Issue 2

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Novel Synthesis Method of Pyrimidine and Pyrazole Derivatives

https://doi.org/10.14233/ajchem.2015.17571
B.E. Missaoui
Laboratoire de Chimie Organique, Universite KASDI Merbah, Ouargla, Algeria; Laboratoire VPRS Universite KASDI Merbah, Ouargla, Algeria
M.R. Ouahrani
Laboratoire de Chimie Organique, Universite KASDI Merbah, Ouargla, Algeria; Laboratoire VPRS Universite KASDI Merbah, Ouargla, Algeria
Y. Kouadri
Laboratoire de Chimie Organique, Universite KASDI Merbah, Ouargla, Algeria; Laboratoire VPRS Universite KASDI Merbah, Ouargla, Algeria
F. Chebrouk
Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques (CRAPC), BP 248, Alger 16004, Algeria
N. Gherraf
Laboratoire des Ressources Naturelles et Aménagement des milieux sensibles, Universite Larbi ben M'hidi, Oum Elbouaghi, Algeria

Corresponding Author(s) : B.E. Missaoui

hadadberini@yahoo.com

Asian Journal of Chemistry, Vol. 27 No. 2 (2015): Vol 27 Issue 2

Abstract

The purpose of this work is the development of a synthetic method that allows access to some heterocyclic compounds containing pyrimidine and pyrazole nuclei. The dehydroacetic acid has been extensively studied as a starting material for the synthesis of natural products that exhibit valuable pharmacological properties. In the first part, we have shown that the pyrimidines can be obtained by reacting dehydroacetic acid with nitrogen binucleophiles reagents. In the second part, we presented the reactivity of the previously synthesized derivatives towards hydrazine to yield derivatives involving pyrimidine and pyrazole motifs. All the synthesized products were subjected to IR, 1H NMR and mass spectra studies.

Keywords

Dehydroacetic acid Pyrimidine Pyrazole
Missaoui, B., Ouahrani, M., Kouadri, Y., Chebrouk, F., & Gherraf, N. (2015). Novel Synthesis Method of Pyrimidine and Pyrazole Derivatives. Asian Journal of Chemistry, 27(2), 671–673. https://doi.org/10.14233/ajchem.2015.17571
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