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Vol. 27 No. 2 (2015): Vol 27 Issue 2

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Synthesis and Crystal Structure of Novel 9-Styrylquinoline Substituted Acridines as Potential Inhibitors of Bacteria

https://doi.org/10.14233/ajchem.2015.16938
Jia-Juan Qi
School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221116, P.R. China; Jiangsu Province R&D Institute of Marine Resources, Huaihai Institute of Technology, Lianyungang 222005, P.R. China
Shu-An Li
Jiangsu Province R&D Institute of Marine Resources, Huaihai Institute of Technology, Lianyungang 222005, P.R. China
Zhen-Ming Zhang
School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221116, P.R. China; Jiangsu Province R&D Institute of Marine Resources, Huaihai Institute of Technology, Lianyungang 222005, P.R. China
Ting Wang
School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221116, P.R. China; Jiangsu Province R&D Institute of Marine Resources, Huaihai Institute of Technology, Lianyungang 222005, P.R. China
Hong-Bo Zhao
School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221116, P.R. China; Jiangsu Province R&D Institute of Marine Resources, Huaihai Institute of Technology, Lianyungang 222005, P.R. China
Xuan Wang
School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221116, P.R. China; Jiangsu Province R&D Institute of Marine Resources, Huaihai Institute of Technology, Lianyungang 222005, P.R. China
Fu-Jun Yin
Jiangsu Province R&D Institute of Marine Resources, Huaihai Institute of Technology, Lianyungang 222005, P.R. China

Corresponding Author(s) : Shu-An Li

li_shu_an@163.com

Asian Journal of Chemistry, Vol. 27 No. 2 (2015): Vol 27 Issue 2

Abstract

Novel compounds of 1,8-dioxodecahydroacridines were designed as potential inhibitors of bacteria and prepared via the multi-component reaction of styrylquinoline aldehydes, dimedone and ammonium acetate in high yield under mild condition. The structure of products has been characterized by X-ray crystal structural analyses, 1H NMR, IR, LC-MC and elemental analysis. The preliminary biological screening shows that target product display a certain degree of activity against the vibrio harveyi at 100 μg mL-1.

Keywords

1 8-Dioxodecahydroacridines Antibacterial activities Quinolines moiety Three component reactions
Qi, J.-J., Li, S.-A., Zhang, Z.-M., Wang, T., Zhao, H.-B., Wang, X., & Yin, F.-J. (2015). Synthesis and Crystal Structure of Novel 9-Styrylquinoline Substituted Acridines as Potential Inhibitors of Bacteria. Asian Journal of Chemistry, 27(2), 435–440. https://doi.org/10.14233/ajchem.2015.16938
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