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Characterization of Hypoglycemic Constituents in Momordica charantia L. and their Hypoglycemic Effect
Corresponding Author(s) : Ling-Yan Jian
Asian Journal of Chemistry,
Vol. 27 No. 2 (2015): Vol 27 Issue 2
Abstract
This study represents the active constituents in Momordica charantia L. and their hypoglycemic effect. Active constituents in Momordica charantia L. were extracted by ethanol percolation extraction and purified by macroporous resin method and preparative thin layer chromatography, post-administration blood glucose in mice was measured using mice model of STZ diabetes. Four compounds were isolated from Momordica charantia L., the determination of blood glucose, hepatic glycogen and fructosamine in mice indicated that blood glucose in mice was lowered after administration of Momordica charantia L. It is suggested that Momordica charantia L. has a hypoglycemic effect.
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References
X. Zhi-yan, C. Di-hua and C. Qi, World Phytomedicines, 14, 14 (1999).
Z.X. Zheng, J.Y. Zuo, J.Y. Liu, J.H. Qiu, Y.H. Ou and C.Y. Xue, J. Hygiene Res., 34, 361 (2005).
X.M. Lin, X.Y. Shen, Z. Long and Q. Yang, J. Hygiene Res., 30, 203 (2001).
L.-H. Lv, J. Chinese Med. Mater., 25, 449 (2002).
Z. Jun-Tian, Modern Experimental Methods in Pharmacology, Beijing Medical University & Peking Union Medical College Joint Press, Beijing, edn 1, pp. 982-1006 (1997).
H. Okabe, Y. Miyahara and T. Yamauchi, Chem. Pharm. Bull. (Tokyo), 30, 4334 (1982); doi:10.1248/cpb.30.4334.
M. Fatope, Y. Takeda, H. Yamashita, H. Okabe and T. Yamauchi, J. Nat. Prod., 53, 1491 (1990); doi:10.1021/np50072a014.
H. Okabe, Y. Miyahara and T. Yamauchi, Chem. Pharm. Bull. (Tokyo), 30, 3977 (1982); doi:10.1248/cpb.30.3977.
Y. Champavier, G. Comte, J. Vercauteren, D.P. Allais and A.J. Chulia, Phytochemistry, 50, 1219 (1999); doi:10.1016/S0031-9422(98)00697-9.