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Vol. 27 No. 1 (2015): Vol 27 Issue 1

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Spectrophotometric Determination of Sitagliptin in Tablets Formulations

https://doi.org/10.14233/ajchem.2015.18446
Saad Antakli
Department of Chemistry, Faculty of Science, University of Aleppo, Aleppo, Syria
Nazeera Sarkees
Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
Mais Hazzouri
Department of Chemistry, Faculty of Science, University of Aleppo, Aleppo, Syria

Corresponding Author(s) : Saad Antakli

antakli@scs-net.org

Asian Journal of Chemistry, Vol. 27 No. 1 (2015): Vol 27 Issue 1

Abstract

A simple, rapid and sensitive spectrophotometric method for the determination of sitagliptin was developed. The method is based on the proton transfer reaction with quinalizarin (Quiz) in dimethyl sulphoxide to form a violet product showing maximum absorbance at 580 nm with molar absorptivity of 10561.16 L mol-1 cm-1. The method follows Beer's law over the concentration range 15-65 μg/mL. The recovery of the method is between 99.520-101.856 % and the relative standard deviation (RSD) of the method is less than 1. 439 %. The method was successfully applied for the determination of sitagliptin in tablets formulations.

Keywords

Sitagliptin Spectrophotometric method Quinalizarin Tablets formulations
Antakli, S., Sarkees, N., & Hazzouri, M. (2014). Spectrophotometric Determination of Sitagliptin in Tablets Formulations. Asian Journal of Chemistry, 27(1), 375–378. https://doi.org/10.14233/ajchem.2015.18446
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