Copyright (c) 2015 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
Solvent-Dependent Conformational Change in Cephalosporin by HPLC Method
Corresponding Author(s) : Shuyu Liu
Asian Journal of Chemistry,
Vol. 27 No. 1 (2015): Vol 27 Issue 1
Abstract
High performance liquid chromatography (HPLC) was generally used to determine drug ingredients. In this article,we used HPLC to detect solvent-dependent conformational change of cephalosporin. Firstly, when the pH value of the mobile phase was constant, it was conducted to research the effect of different solvents on cephalosporin configuration. Then, when solvent was determined, it was carried out to test the influence of pH value of the mobile phase on cephalosporin configuration. It is found that the pH value of mobile phase and different solvents had some effect on cephalosporin configuration by HPLC.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
- N.K. Jena and N.A. Murugan, J. Phys. Chem. C, 117, 25059 (2013); doi:10.1021/jp406576m.
- K.N. Nwogu, Engl. Specif. Purposes, 16, 119 (1997); doi:10.1016/S0889-4906(97)85388-4.
- J. Mehta, Leuk. Res., 21, 183 (1997); doi:10.1016/S0145-2126(96)00075-6.
- M. Kanai, T. Hirano, I. Azumaya, I. Okamoto, H. Kagechika and A. Tanatani, Tetrahedron, 68, 2778 (2012); doi:10.1016/j.tet.2012.02.012.
- C.H. O'Callaghan, S.M. Kirby, A. Morris, R.E. Waller and R.E. Duncombe, J. Bacteriol., 110, 988 (1972).
- R. Yamasaki, A. Tanatani, I. Azumaya, S. Saito, K. Yamaguchi and H. Kagechika, Org. Lett., 5, 1265 (2003); doi:10.1021/ol034344g.
- J. Leis, K.D. Klika and M. Karelson, Tetrahedron, 54, 7497 (1998); doi:10.1016/S0040-4020(98)00379-2.
- R. Crespo‐Otero, A. Mardyukov, E. Sanchez‐Garcia, M. Barbatti and W. Sander, ChemPhysChem, 14, 827 (2013); doi:10.1002/cphc.201200573.
- I. Okamoto, M. Nabeta, M. Yamamoto, M. Mikami, T. Takeya and O. Tamura, Tetrahedron Lett., 47, 7143 (2006); doi:10.1016/j.tetlet.2006.08.012.
- M. Gróf, A. Gatial, V. Milata, N. Prónayová, L. Sümmchen and R. Salzer, J. Mol. Struct., 843, 1 (2007); doi:10.1016/j.molstruc.2006.12.023.
- A. Zimniak, I. Oszczapowicz, A. Sikora and I. Wawer, J. Mol. Struct., 443, 115 (1998); doi:10.1016/S0022-2860(97)00370-0.
References
N.K. Jena and N.A. Murugan, J. Phys. Chem. C, 117, 25059 (2013); doi:10.1021/jp406576m.
K.N. Nwogu, Engl. Specif. Purposes, 16, 119 (1997); doi:10.1016/S0889-4906(97)85388-4.
J. Mehta, Leuk. Res., 21, 183 (1997); doi:10.1016/S0145-2126(96)00075-6.
M. Kanai, T. Hirano, I. Azumaya, I. Okamoto, H. Kagechika and A. Tanatani, Tetrahedron, 68, 2778 (2012); doi:10.1016/j.tet.2012.02.012.
C.H. O'Callaghan, S.M. Kirby, A. Morris, R.E. Waller and R.E. Duncombe, J. Bacteriol., 110, 988 (1972).
R. Yamasaki, A. Tanatani, I. Azumaya, S. Saito, K. Yamaguchi and H. Kagechika, Org. Lett., 5, 1265 (2003); doi:10.1021/ol034344g.
J. Leis, K.D. Klika and M. Karelson, Tetrahedron, 54, 7497 (1998); doi:10.1016/S0040-4020(98)00379-2.
R. Crespo‐Otero, A. Mardyukov, E. Sanchez‐Garcia, M. Barbatti and W. Sander, ChemPhysChem, 14, 827 (2013); doi:10.1002/cphc.201200573.
I. Okamoto, M. Nabeta, M. Yamamoto, M. Mikami, T. Takeya and O. Tamura, Tetrahedron Lett., 47, 7143 (2006); doi:10.1016/j.tetlet.2006.08.012.
M. Gróf, A. Gatial, V. Milata, N. Prónayová, L. Sümmchen and R. Salzer, J. Mol. Struct., 843, 1 (2007); doi:10.1016/j.molstruc.2006.12.023.
A. Zimniak, I. Oszczapowicz, A. Sikora and I. Wawer, J. Mol. Struct., 443, 115 (1998); doi:10.1016/S0022-2860(97)00370-0.