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Vol. 27 No. 1 (2015): Vol 27 Issue 1

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Carboxyl Activation of 2-Mercapto-4,6-dimethylpyrimidine through N-Acyl-4,6-dimethylpyrimidine-2-thione: A Chemical and Spectrophotometric Investigation

https://doi.org/10.14233/ajchem.2015.17607
M.P. Rajan
Department of Chemical Sciences, Mahatma Gandhi University, Kottayam-686 560, India

Corresponding Author(s) : M.P. Rajan

mpr4321@gmail.com; rajan.mp@rediffmail.com

Asian Journal of Chemistry, Vol. 27 No. 1 (2015): Vol 27 Issue 1

Abstract

2-Mercapto-4,6-dimethylpyrimidine, as effective carboxyl activating group, has been successfully proved by converting it into respective acyl derivatives and the subsequent conversion to the amides and esters respectively using amines, amino alcohols and alcohols. The aminolysis and esterification were monitored chemically and spectrophotometrically. This paved way to establish that the above mercaptopyrimidine derivative is an efficient carboxyl activating group applicable in solid phase peptide synthesis.

Keywords

Pyrimidine thiols Activation of carboxyl group Solid phase peptide synthesis
Rajan, M. (2014). Carboxyl Activation of 2-Mercapto-4,6-dimethylpyrimidine through N-Acyl-4,6-dimethylpyrimidine-2-thione: A Chemical and Spectrophotometric Investigation. Asian Journal of Chemistry, 27(1), 287–291. https://doi.org/10.14233/ajchem.2015.17607
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