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Vol. 27 No. 1 (2015): Vol 27 Issue 1

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Synthesis and Biological Screening of Heterocyclic Ligands-Pyrazole Derivatives Metal Complexes

https://doi.org/10.14233/ajchem.2015.17009
Tasneem Ullah Sheikh
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan; Department of Chemistry, Government College of Education, Afzalpur, Pakistan
Muhammad Naeem Khan
Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore, Pakistan
Ghulam Hussain
Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan; Shafi Reso Chem, Ferozepur Road, Lahore, Pakistan
Muhammad Makshoof Athar
Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan
Muhammad Ashraf
Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Faizul Hassan Nasim
Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Shafia Arshad
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Karamat Mahmood
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Misbahul Ain Khan
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan; Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan

Corresponding Author(s) : Muhammad Naeem Khan

changwani_1@yahoo.com

Asian Journal of Chemistry, Vol. 27 No. 1 (2015): Vol 27 Issue 1

Abstract

The Cu(II), Ni(II) and Zn(II) complexes of 4-acyl-5-pyrazolones along with other novel complexes of 4-acyl-5-pyrazolones with the co-ligand 1,10-phenanthroline were prepared and screened for their antibacterial and antifungal activity. Zinc complexes 11, 12 and 13 showed powerful antifungal activity while some of the nickel complexes 7-10 exhibited effective antibacterial activity against both Gram-positive and Gram-negative bacteria.

Keywords

Synthesis Biological screening Metal complexes Pyrazole
Ullah Sheikh, T., Naeem Khan, M., Hussain, G., Makshoof Athar, M., Ashraf, M., Hassan Nasim, F., … Ain Khan, M. (2014). Synthesis and Biological Screening of Heterocyclic Ligands-Pyrazole Derivatives Metal Complexes. Asian Journal of Chemistry, 27(1), 257–260. https://doi.org/10.14233/ajchem.2015.17009
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References
  1. H.R. Wiley and P. Wiley Pyrazolones, Pyrazolidones and Derivatives, Interscience Publishers, John Wiley & Sons New York (1964).
  2. L.S. Goodmann and A. Gilmann, The Pharmacological Basis of Therapeutics, Macmillan Co., edn 4, p. 334 (1970).
  3. M.A. Khan, A.G. Cosenza and G.P. Ellis, J. Heterocycl. Chem., 19, 1077 (1982); doi:10.1002/jhet.5570190520; M.A. Khan, M.C. Pagotto and G.P. Ellis, Heterocycles, 6, 983 (1977); doi:10.3987/R-1977-07-0983; M.A. Khan, G.P. Ellis and M.C. Pagotto, J. Heterocycl. Chem., 38, 193 (2001); doi:10.1002/jhet.5570380129.
  4. F. Marchetti, C. Pettinari and R. Pettinari, Coord. Chem. Rev., 249, 2909 (2005); doi:10.1016/j.ccr.2005.03.013.
  5. I. Ahmad, M.A. Khan and M. Athar, Pak. J. Sci. Ind. Res., 44, 268 (2001); K. Mahmud, M.A. Khan and M.Z. Iqbal, Pak. J. Biosci., 4, 1000 (2001); M. Nasrullah, M.A. Khan, M.N. Khan, M.G. Humphrey, F.H. Nasim, F. Chaudhry, M.G. Abidi, U. Farooq and M.A. Munawar, Asian J. Chem., 25, 419 (2013); doi:10.14233/ajchem.2013.13131; M. Nasrullah, M.A. Khan, M.N. Khan, M.G. Humphrey, S. Aslam, M. Ahmad, M.A. Munawar, T. Maqbool and W.-O. Lin, Asian J. Chem., 25, 7293 (2013); doi:10.14233/ajchem.2013.14542.
  6. B.S. Jensen, H. Meier, K. Lundquist and S. Refn, Acta Chem. Scand., 13, 1668 (1959); doi:10.3891/acta.chem.scand.13-1668.
  7. T.U. Sheikh, M.A. Khan, M.N. Arshad, I.U. Khan and H. Stoeckli-Evans, Acta Crystallogr., 65E, o330 (2009); doi:10.1107/S1600536809001470.
  8. A.K. Patel, R.J. Patel, R.M. Patel and R.M. Patel, J. Chil. Chem. Soc., 54, 228 (2009); doi:10.4067/S0717-97072009000300006.
  9. M. Kaspady, V.K. Narayanaswamy, M. Raju and G.K. Rao, Lett. Drug Des. Discov., 6, 21 (2009); doi:10.2174/157018009787158481.
  10. C.-R. Yang, Y. Zhang, M.R. Jacob, S.I. Khan, Y.-J. Zhang and X.-C. Li, Antimicrob. Agents Chemother., 50, 1710 (2006); doi:10.1128/AAC.50.5.1710-1714.2006.
  11. M.A. Khan, M.A. Munawar and M. Athar, J. Sci. Res., 37, 35 (2007).
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