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Vol. 27 No. 1 (2015): Vol 27 Issue 1

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Synthesis, Characterization and Antitumor Activity of Novel Cadmium Complex with Laminine Ligand

https://doi.org/10.14233/ajchem.2015.16879
Xiuwen Lv
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, Shandong Province, P.R. China
Caifeng Bi
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, Shandong Province, P.R. China
Yuhua Fan
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, Shandong Province, P.R. China
Xia Zhang
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, Shandong Province, P.R. China
Nan Zhang
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, Shandong Province, P.R. China
Pengfei Zhang
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, Shandong Province, P.R. China

Corresponding Author(s) : Caifeng Bi

bicaifeng301@163.com

Asian Journal of Chemistry, Vol. 27 No. 1 (2015): Vol 27 Issue 1

Abstract

A novel cadmium(Cd) complex [Cd(C9H20N2O2)2·(CH3COO)2·2H2O] (C9H20N2O2: laminine) was synthesized and characterized by elemental analysis, IR spectroscopy, 1H NMR and thermogravimetric analysis. The anticancer activity of the laminine-Cd complex on MDA-MB-231 breast cancer cells was also investigated. The results showed that the laminine-Cd complex could inhibit the chymotrypsin-like activity of cell-free proteasome in vitro and induce apoptosis in cultured breast cancer MDA-MB-231 cells.

Keywords

Laminine Cadmium complex Proteasome inhibitor Anticancer activity
Lv, X., Bi, C., Fan, Y., Zhang, X., Zhang, N., & Zhang, P. (2014). Synthesis, Characterization and Antitumor Activity of Novel Cadmium Complex with Laminine Ligand. Asian Journal of Chemistry, 27(1), 224–228. https://doi.org/10.14233/ajchem.2015.16879
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