Determination of Lomefloxacin and Gatifloxacin in Urine by High Performance Liquid Chromatography with Polymer Monolith Microextraction

Z.Z. Wang; J. Fan; S.J. Shao

doi:10.14233/ajchem.2015.16840

Issue

Vol. 27 No. 1 (2015): Vol 27 Issue 1

Issue Published : December 27, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Determination of Lomefloxacin and Gatifloxacin in Urine by High Performance Liquid Chromatography with Polymer Monolith Microextraction

https://doi.org/10.14233/ajchem.2015.16840

Z.Z. Wang

Key Laboratory for Natural Medicine of Gansu Province, Key Laboratory of Chemistry of Northwestern Plant Resources, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P.R. China; University of Chinese Academy of Sciences, Beijing, P.R. China

J. Fan

Department of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang, P.R. China*Corresponding author: E-mail: shilywzz@163.com

S.J. Shao

Corresponding Author(s) : S.J. Shao

shilywzz@163.com

Asian Journal of Chemistry, Vol. 27 No. 1 (2015): Vol 27 Issue 1
Article Published : December 29, 2014

Abstract

A method based on poly (methacrylic acid-co-ethylene glycol dimethacrylate) (MAA-EGDMA) monolith microextraction (PMME) was first proposed for sensitive high performance liquid chromatography-ultraviolet (HPLC-UV) analysis of lomefloxacin and gatifloxacin in urine samples. The conditions of PMME were optimized for the improvement of extraction efficiency and reduction of the matrix interferences from urine samples.Under the optimal condition, the eluate solution allowed direct analysis by HPLC. The best separation was achieved within 8 min using a mobile phase of acetonitrile-0.025 mol/L triethylamine (adjust pH to 2.5 by phosphoric acid) buffer solution (33:67, v/v) at room temperature. The proposed PMME-HPLC method exhibited detection limits of 3.4 ng/mL for lomefloxacin (19 ng/mL for gatifloxacin) with satisfactory precision (RSD £ 5.7 %) and recoveries between 85.0 % and 106.8 % over a linear range 20-2000 ng/mL (50-1000 ng/mL for gatifloxacin). The proposed method can be used for analysis of lomefloxacin and gatifloxacin in urine samples.

Keywords

High performance liquid chromatography Lomefloxacin Gatifloxacin Polymer monolith microextraction

Wang, Z., Fan, J., & Shao, S. (2014). Determination of Lomefloxacin and Gatifloxacin in Urine by High Performance Liquid Chromatography with Polymer Monolith Microextraction. Asian Journal of Chemistry, 27(1), 177–181. https://doi.org/10.14233/ajchem.2015.16840

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J.A. Linder, E.S. Huang, M.A. Steinman, R. Gonzales and R.S. Stafford, Am. J. Med., 118, 259 (2005); doi:10.1016/j.amjmed.2004.09.015.

A. Espinosa-Mansilla, A.M. de la Pena, D.G. Gomez and F.S. Lopez, Talanta, 68, 1215 (2006); doi:10.1016/j.talanta.2005.07.035.

J. De Smet, K. Boussery, K. Colpaert, P. De Sutter, P. De Paepe, J. Decruyenaere and J. Van Bocxlaer, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 877, 961 (2009); doi:10.1016/j.jchromb.2009.02.039.

X. Huang, Y. Wang, Y. Liu and D. Yuan, J. Sep. Sci., 36, 3210 (2013); doi:10.1002/jssc.201300355.

A. Pena, D. Chmielova, C.M. Lino and P. Solich, J. Sep. Sci., 30, 2924 (2007); doi:10.1002/jssc.200700363.

M. Ramos Payan, M.A. Bello Lopez, R. Fernandez-Torres, J.A. Gonzalez and M. Callejon Mochon, J. Pharm. Biomed. Anal., 55, 332 (2011); doi:10.1016/j.jpba.2011.01.037.

M. Ramos-Payán, M. Villar-Navarro, R. Fernández-Torres, M. Callejón-Mochón and M.Á. Bello-López, Anal. Bioanal. Chem., 405, 2575 (2013); doi:10.1007/s00216-012-6664-5.

M. Sturini, A. Speltini, L. Pretali, E. Fasani and A. Profumo, J. Sep. Sci., 32, 3020 (2009); doi:10.1002/jssc.200900135.

F. Hernández, J.V. Sancho, M. Ibáñez and C. Guerrero, Trends Analyt. Chem., 26, 466 (2007); doi:10.1016/j.trac.2007.01.012.

M. Petrović, M.D. Hernando, M.S. Díaz-Cruz and D. Barceló, J. Chromatogr. A, 1067, 1 (2005); doi:10.1016/j.chroma.2004.10.110.

J.Z. Shen, L.M. Guo, F. Xu, Q.X. Rao, X. Xia, X.W. Li and S.Y. Ding, Chromatographia, 71, 383 (2010); doi:10.1365/s10337-009-1463-7.

N.M. Vieno, T. Tuhkanen and L. Kronberg, J. Chromatogr. A, 1134, 101 (2006); doi:10.1016/j.chroma.2006.08.077.

K. Mitani and H. Kataoka, Anal. Chim. Acta, 562, 16 (2006); doi:10.1016/j.aca.2006.01.053.

C. Fierens, S. Hillaert and W. Van den Bossche, J. Pharm. Biomed. Anal., 22, 763 (2000); doi:10.1016/S0731-7085(99)00282-4.

I.S. Ibarra, J.A. Rodriguez, M.E. Paez-Hernandez, E.M. Santos and J.M. Miranda, Electrophoresis, 33, 2041 (2012); doi:10.1002/elps.201100559.

G. Morales-Cid, S. Cardenas, B.M. Simonet and M. Valcarcel, Anal. Chem., 81, 3188 (2009); doi:10.1021/ac900234j.

Y.X. Fan, Z.R. Tian and W.D. Qin, Anal. Lett., 42, 1057 (2009); doi:10.1080/00032710902890363.

M. Lombardo-Agui, A.M. Garcia-Campana, L. Gamiz-Gracia and C. Cruces Blanco, J. Chromatogr. A, 1217, 2237 (2010); doi:10.1016/j.chroma.2010.02.016.

E.M. Golet, A.C. Alder, A. Hartmann, T.A. Ternes and W. Giger, Anal. Chem., 73, 3632 (2001); doi:10.1021/ac0015265.

M.D. Prat, J. Benito, R. Compañó, J.A. Hernández-Arteseros and M. Granados, J. Chromatogr. A, 1041, 27 (2004); doi:10.1016/j.chroma.2004.04.042.

D.L. Xiao, P. Dramou, N.Q. Xiong, H. He, D.H. Yuan, H. Dai, H. Li, X.M. He, J. Peng and N. Li, Analyst (Lond.), 138, 3287 (2013); doi:10.1039/c3an36755j.

M.M. Zheng, R. Gong, X. Zhao and Y.Q. Feng, J. Chromatogr. A, 1217, 2075 (2010); doi:10.1016/j.chroma.2010.02.011.

Y. Fan, Y.Q. Feng, J.T. Zhang, S.L. Da and M. Zhang, J. Chromatogr. A, 1074, 9 (2005); doi:10.1016/j.chroma.2005.03.115.

M. Zhang, F. Wei, Y.F. Zhang, J. Nie and Y.Q. Feng, J. Chromatogr. A, 1102, 294 (2006); doi:10.1016/j.chroma.2005.10.057.

J.F. Huang, B. Lin, Q.W. Yu and Y.Q. Feng, Anal. Bioanal. Chem., 384, 1228 (2006); doi:10.1007/s00216-005-0270-8.

J.F. Huang, H.J. Zhang and Y.Q. Feng, J. Agric. Food Chem., 54, 9279 (2006); doi:10.1021/jf062246e.

J.F. Huang, H.J. Zhang, B. Lin, Q.W. Yu and Y.Q. Feng, Rapid Commun. Mass Spectrom., 21, 2895 (2007); doi:10.1002/rcm.3165.

Y. Fan, Y.Q. Feng, S.L. Da and Z.G. Shi, Anal. Chim. Acta, 523, 251 (2004); doi:10.1016/j.aca.2004.07.052.

Issue

Vol. 27 No. 1 (2015): Vol 27 Issue 1

Determination of Lomefloxacin and Gatifloxacin in Urine by High Performance Liquid Chromatography with Polymer Monolith Microextraction

Corresponding Author(s) : S.J. Shao

Abstract

Keywords

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