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Studies on Structure-Activity Relationship of N-Substituted Phenyl Cinnamide Compounds with Antitumor Activity
Corresponding Author(s) : Hui-Min Bi
Asian Journal of Chemistry,
Vol. 27 No. 1 (2015): Vol 27 Issue 1
Abstract
The relationship of structure and antitumor activity of N-substituted phenyl cinnamide derivatives were studied. The main influntcing factor is LUMO orbital of molecular. When these compounds reacted with the receptors, they could accept the electrons. The C(8) atom on carbonyl is the active site. The result of QSAR showed that there is a positive correlation between the antitumor activity and the ELUMO of compounds.
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- N. Motohashi, C. Yamagami, H. Tokuda, Y. Okuda, E. Ichiishi, T. Mukainaka, H. Nishino and Y. Saito, Mutat. Res., 464, 247 (2000); doi:10.1016/S1383-5718(99)00198-9.
- Y. Shi, Q.X. Chen, Q. Wang, K. Song and L. Qiu, Food Chem., 92, 707 (2005); doi:10.1016/j.foodchem.2004.08.031.
- A.H. Banskota, T. Nagaoka, L.Y. Sumioka, Y. Tezuka, S. Awale, K. Midorikawa, K. Matsushige and S. Kadota, J. Ethnopharmacol., 80, 67 (2002); doi:10.1016/S0378-8741(02)00022-3.
- C. Tan, W.Y. Zhu and Y. Lu, Chin. Med. J., 115, 1859 (2002).
- X.F. Jiang and Y.S. Zhen, Anticancer Drugs, 11, 49 (2000); doi:10.1097/00001813-200001000-00008.
- D.R. Welch, D.E. Harperf and K.H. Yohem, Clin. Exp. Metastasis, 11, 201 (1993); doi:10.1007/BF00114978.
- N.D. Galpalli and S.C. Chaturvedi, Asian J. Chem., 17, 877 (2005).
- A. Nagpal and M. Tiwari, Asian J. Chem., 17, 1669 (2005).
- Q.L. Wei, J. Gao, J. Zou, J. Wan and S.-S. Zhang, Asian J. Chem., 19, 1262 (2007).
- G.H. Hu, Degree Thesis, Wenzhou Medical College (2010).
- T.B. Wei, Y.L. Leng, Y.C. Wang, J.H. Zhang and Y.M. Zhang, Chin. J. Org. Chem., 29, 216 (2009).
- D.B. Zhang, Y.H. Ren, D.W. Fu, B. Yan, J.-R. Song and X.-Q. Lu, Acta Chim. Sin., 66, 2409 (2008).
References
N. Motohashi, C. Yamagami, H. Tokuda, Y. Okuda, E. Ichiishi, T. Mukainaka, H. Nishino and Y. Saito, Mutat. Res., 464, 247 (2000); doi:10.1016/S1383-5718(99)00198-9.
Y. Shi, Q.X. Chen, Q. Wang, K. Song and L. Qiu, Food Chem., 92, 707 (2005); doi:10.1016/j.foodchem.2004.08.031.
A.H. Banskota, T. Nagaoka, L.Y. Sumioka, Y. Tezuka, S. Awale, K. Midorikawa, K. Matsushige and S. Kadota, J. Ethnopharmacol., 80, 67 (2002); doi:10.1016/S0378-8741(02)00022-3.
C. Tan, W.Y. Zhu and Y. Lu, Chin. Med. J., 115, 1859 (2002).
X.F. Jiang and Y.S. Zhen, Anticancer Drugs, 11, 49 (2000); doi:10.1097/00001813-200001000-00008.
D.R. Welch, D.E. Harperf and K.H. Yohem, Clin. Exp. Metastasis, 11, 201 (1993); doi:10.1007/BF00114978.
N.D. Galpalli and S.C. Chaturvedi, Asian J. Chem., 17, 877 (2005).
A. Nagpal and M. Tiwari, Asian J. Chem., 17, 1669 (2005).
Q.L. Wei, J. Gao, J. Zou, J. Wan and S.-S. Zhang, Asian J. Chem., 19, 1262 (2007).
G.H. Hu, Degree Thesis, Wenzhou Medical College (2010).
T.B. Wei, Y.L. Leng, Y.C. Wang, J.H. Zhang and Y.M. Zhang, Chin. J. Org. Chem., 29, 216 (2009).
D.B. Zhang, Y.H. Ren, D.W. Fu, B. Yan, J.-R. Song and X.-Q. Lu, Acta Chim. Sin., 66, 2409 (2008).