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New FI-Spectrophotometric Methods for Determination of Olsalazine in Pure and Pharmaceutical Preparations via Complexation with Quinalizarin Reagent
Corresponding Author(s) : Bushra B. Qassim
Asian Journal of Chemistry,
Vol. 27 No. 12 (2015): Vol 27 Issue 12
Abstract
A new, rapid and sensitive flow injection analysis (FIA)-spectrophotometric methods for the determination of trace amounts of olsalazine in aqueous solution and in pharmaceutical preparations are described. The methods are based on the charge transfer reaction between olsalazine and quinalizarin in methanol to form an intense reddish orange, methanol-soluble product that is stable and has a maximum absorption at 570 nm. Beer’s law was obeyed over the concentration range of 0.5-45 and 10-150 μg mL-1 with the detection limits of 0.125 and 2.480 μg mL-1 for batch and flow injection methods, respectively. The optimum conditions (chemical and physical) experimental parameters affecting on the sensitivity and stability of the coloured product are carefully investigated. The optimized flow injection analysis system is able to determine olsalazine through put 52 h-1. Common exicpients used as additives in drugs formulations do not interfered in the proposed methods. The methods were applied successfully to the determination of olsalazine in dosage forms. The results were compared statistically with the British pharmacopoeia method.
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- Martindal, The Extra Pharmacopoeia, The Pharmaceutical Press, London, edn 46, pp. 1200 (2000).
- K. Lauritsen, L.S. Laursen, K. Bukhave and J.R. Madsen, Eur. J. Gastroenterol. Hepatol., 29, 974 (1988).
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- B. Uslu, S. Yilmaz and S.A. Ozkan, Pharmazie, 56, 629 (2001).
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References
S.S. Rao, S.A. Dundas, C.D. Holdsworth, P.A. Cann, K.R. Palmer and C.L. Corbett, Eur. J. Gastroenterol. Hepatol., 30, 675 (1989).
E.M. Ryde and N.O. Ahnfelt, Eur. J. Clin. Pharmacol., 34, 481 (1988); doi:10.1007/BF01046706.
S.Yu. Garmonov, Z.C. Nguyen, I.F. Mingazetdinov, L.M. Yusupova, N.S. Shitova, R.N. Ismailova and VF. Sopin, Pharm. Chem. J., 45, 757 (2012); doi:10.1007/s11094-012-0719-y.
Martindal, The Extra Pharmacopoeia, The Pharmaceutical Press, London, edn 46, pp. 1200 (2000).
K. Lauritsen, L.S. Laursen, K. Bukhave and J.R. Madsen, Eur. J. Gastroenterol. Hepatol., 29, 974 (1988).
B. Nigovic, Z. Mandic, B. Simunic and I. Fistric, J. Pharm. Biomed. Anal., 26, 987 (2001); doi:10.1016/S0731-7085(01)00463-0.
B. Uslu, S. Yilmaz and S.A. Ozkan, Pharmazie, 56, 629 (2001).
M. Dahlund, A. Olin, K. Grjotheim, L.V. Vilkov, H.V. Volden, K. Maartmann-Moe and S. Wold, Acta Chem. Scand., 44, 321 (1990); doi:10.3891/acta.chem.scand.44-0321.
F. Oakley, M. Meso, J.P. Iredale, K. Green, C.J. Marek, X. Zhou, M.J. May, H. Millward-Sadler, M.C. Wright and D.A. Mann, Gastroenterology, 128, 108 (2005); doi:10.1053/j.gastro.2004.10.003.
H. Chen, Y. Cui, B. Zhang, B. Liu, G. Chen and D. Tang, Inorg. Chim. Acta, 728, 18 (2012); doi:10.1016/j.aca.2012.03.052.
Olsalazine; British Pharmacopoeia (2012).
G. Cozza, M. Mazzorana, E. Papinutto, J. Bain, M. Elliott, G. di Maira, A. Gianoncelli, M.A. Pagano, S. Sarno, M. Ruzzene, R. Battistutta, F. Meggio, S. Moro, G. Zagotto and L.A. Pinna, Biochem. J., 421, 387 (2009); doi:10.1042/BJ20090069.
D. Bradley, G. Williams and M. Lawton, J. Org. Chem., 75, 8351 (2010); doi:10.1021/jo101589h.
K. Basavaiah and V.S. Charan, J. Sci. Asia, 28, 359 (2002); doi:10.2306/scienceasia1513-1874.2002.28.359.
C.E.R. de Paula, V.G.K. Almeida and R.J. Cassella, J. Braz. Chem. Soc., 21, 1664 (2010); doi:10.1590/S0103-50532010000900010.
H. Irving and T.B. Pierce, J. Chem. Soc., 2665 (1959); doi:10.1039/JR9590002565.
J.N. Miller and J.C. Miller, Statistics and Chemometrics for Analytical Chemistry, Pearson Education Limited, London, edn 4, pp. 35-49 (2000).
L.G. Hargis, Analytical Chemistry, Prentice-Hall Inc., New Jersey (1998).
S.M. Malipatil, M. Dipali and B.S. Athanikar, Res. J. Pharm. Technol., 4, 1852 (2011).