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Structural Identification of Pyrazoles and Pyrimidines Using 2D HMBC NMR and Single-Crystal X-Ray Diffraction
Corresponding Author(s) : A.S. Al-Bogami
Asian Journal of Chemistry,
Vol. 27 No. 12 (2015): Vol 27 Issue 12
Abstract
A facile and highly efficient microwave-assisted synthesis of functionalized pyrazoles and pyrimidines based on the regiospecific synthesis is reported. The present work provides unambiguous evidence of the pyrazoles was determined using 2D HMBC NMR. The structure for pyrimidine have been confirmed by single-crystal X-ray diffraction.
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- R.L. Agrawal, N.C. Dwivedi, M. Agrawal, S. Jain and A. Agrawal, Indian J. Tuberc., 55, 94 (2008).
- A. Tostmann, M.J. Boeree, W.H.M. Peters, H.M.J. Roelofs, R.E. Aarnoutse, A.J.A.M. van der Ven and P.N.R. Dekhuijzen, Int. J. Antimicrob., 31, 577 (2008); doi:10.1016/j.ijantimicag.2008.01.022.
- D. Coskun, M. Ahmedzade and S. Kirbag, E-J. Chem., 8, 1574 (2011); doi:10.1155/2011/806854.
- S. Khatib, O. Nerya, R. Musa, M. Shmuel, S. Tamir and J. Vaya, Bioorg. Med. Chem., 13, 433 (2005); doi:10.1016/j.bmc.2004.10.010.
- C.M. Devia, N.B. Pappano and N.B. Debattista, Rev. Microbiol., 29, 307 (1998); doi:10.1590/S0001-37141998000400014.
- S.S. Korgaokar, H. Parekh and H. Patil, Indian J. Pharm., 58, 222 (1996).
- A. Bilgin, R. Sunal and A. Palaska, Arzneimittelforschung, 43, 1041 (1993).
- A.M. Nasef, E.S.O. Naem and A. Shabrawy, J. Egypt. Pharm. Sci., 33, 463 (1992).
- Y. Jayamma and V.M. Reddy, Indian J. Heterocycl. Chem., 6, 111 (1996).
- S. Ducki, Anticancer. Agents Med. Chem., 9, 336 (2009); doi:10.2174/1871520610909030336.
- K.M. Hassan Hilmy, M.M.A. Khalifa, M.A. Allah Hawata, R.M. AboAlzeen Keshk and A.A. El-Torgman, Eur. J. Med. Chem., 45, 5243 (2010); doi:10.1016/j.ejmech.2010.08.043.
- H.N. Hafez and A.B.A. El-Gazzar, Bioorg. Med. Chem. Lett., 18, 5222 (2008); doi:10.1016/j.bmcl.2008.08.071.
- M. Ban, H. Taguchi, T. Katsushima, S. Aoki and A. Watanabe, Bioorg. Med. Chem., 6, 1057 (1998); doi:10.1016/S0968-0896(98)00064-9.
- B. Ramesh and B.S. Rao, E-J. Chem., 7, 433 (2010); doi:10.1155/2010/404715.
- A.-S.S. Hamad Elgazwy, N.S.M. Ismail and H.S.A. Elzahabi, Bioorg. Med. Chem., 18, 7639 (2010); doi:10.1016/j.bmc.2010.08.033.
References
R.L. Agrawal, N.C. Dwivedi, M. Agrawal, S. Jain and A. Agrawal, Indian J. Tuberc., 55, 94 (2008).
A. Tostmann, M.J. Boeree, W.H.M. Peters, H.M.J. Roelofs, R.E. Aarnoutse, A.J.A.M. van der Ven and P.N.R. Dekhuijzen, Int. J. Antimicrob., 31, 577 (2008); doi:10.1016/j.ijantimicag.2008.01.022.
D. Coskun, M. Ahmedzade and S. Kirbag, E-J. Chem., 8, 1574 (2011); doi:10.1155/2011/806854.
S. Khatib, O. Nerya, R. Musa, M. Shmuel, S. Tamir and J. Vaya, Bioorg. Med. Chem., 13, 433 (2005); doi:10.1016/j.bmc.2004.10.010.
C.M. Devia, N.B. Pappano and N.B. Debattista, Rev. Microbiol., 29, 307 (1998); doi:10.1590/S0001-37141998000400014.
S.S. Korgaokar, H. Parekh and H. Patil, Indian J. Pharm., 58, 222 (1996).
A. Bilgin, R. Sunal and A. Palaska, Arzneimittelforschung, 43, 1041 (1993).
A.M. Nasef, E.S.O. Naem and A. Shabrawy, J. Egypt. Pharm. Sci., 33, 463 (1992).
Y. Jayamma and V.M. Reddy, Indian J. Heterocycl. Chem., 6, 111 (1996).
S. Ducki, Anticancer. Agents Med. Chem., 9, 336 (2009); doi:10.2174/1871520610909030336.
K.M. Hassan Hilmy, M.M.A. Khalifa, M.A. Allah Hawata, R.M. AboAlzeen Keshk and A.A. El-Torgman, Eur. J. Med. Chem., 45, 5243 (2010); doi:10.1016/j.ejmech.2010.08.043.
H.N. Hafez and A.B.A. El-Gazzar, Bioorg. Med. Chem. Lett., 18, 5222 (2008); doi:10.1016/j.bmcl.2008.08.071.
M. Ban, H. Taguchi, T. Katsushima, S. Aoki and A. Watanabe, Bioorg. Med. Chem., 6, 1057 (1998); doi:10.1016/S0968-0896(98)00064-9.
B. Ramesh and B.S. Rao, E-J. Chem., 7, 433 (2010); doi:10.1155/2010/404715.
A.-S.S. Hamad Elgazwy, N.S.M. Ismail and H.S.A. Elzahabi, Bioorg. Med. Chem., 18, 7639 (2010); doi:10.1016/j.bmc.2010.08.033.