Design, Synthesis and Biological Evaluation of Benzimidazolyl and Benzothiazolyl Picolinamide Derivatives as Antimicrobial Agents

Vasu Namani; B. Bharath Kumar Goud; Y. Bharathi Kumari; Ramesh Kumbham; Kannoju Balakrishna; Bhukya Bhima

doi:10.14233/ajchem.2015.19235

Issue

Vol. 27 No. 12 (2015): Vol 27 Issue 12

Issue Published : August 29, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Design, Synthesis and Biological Evaluation of Benzimidazolyl and Benzothiazolyl Picolinamide Derivatives as Antimicrobial Agents

https://doi.org/10.14233/ajchem.2015.19235

Vasu Namani

Suven Life Sciences Ltd, Jeedimetla, Hyderabad-500 055, India

B. Bharath Kumar Goud

Suven Life Sciences Ltd, Jeedimetla, Hyderabad-500 055, India

Y. Bharathi Kumari

Department of Chemistry, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 072, India

Ramesh Kumbham

Rational Laboratories Private Ltd, Mallapur, Hyderabad-500 007, India

Kannoju Balakrishna

Department of Microbiology, University College of Science, Osmania University, Hyderabad-500 007, India

Bhukya Bhima

Department of Microbiology, University College of Science, Osmania University, Hyderabad-500 007, India

Corresponding Author(s) : B. Bharath Kumar Goud

bkgoud2014@gmail.com

Asian Journal of Chemistry, Vol. 27 No. 12 (2015): Vol 27 Issue 12
Article Published : August 29, 2015

Abstract

A series of benzothiazolyl amides and benzimidazolyl amides (6a-f) has been synthesized from the coupling reaction of substituted picolinic acid with benzothiazole and benzimidazoles, respectively. The newly synthesized compounds were evaluated for their efficacy as antimicrobial agents against various Gram-positive and Gram-negative strains of bacteria and fungal strains. Amongst these compounds 6f was found to be the most potent against Bacillus subtilis and Candida albicans. Moreover, other compounds also found to be potential antibacterial agents in comparison to the standard drugs.

Keywords

Benzothiazoles Benzimidazoles Antimicrobial activities

Namani, V., Bharath Kumar Goud, B., Bharathi Kumari, Y., Kumbham, R., Balakrishna, K., & Bhima, B. (2015). Design, Synthesis and Biological Evaluation of Benzimidazolyl and Benzothiazolyl Picolinamide Derivatives as Antimicrobial Agents. Asian Journal of Chemistry, 27(12), 4575–4578. https://doi.org/10.14233/ajchem.2015.19235

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References

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References

H. Bujdáková and M. Múčková, Int. J. Antimicrob. Agents, 4, 303 (1994); doi:10.1016/0924-8579(94)90030-2.

A. Latrofa, M. Franco, A. Lopedota, A. Rosato, D. Carone and C. Vitali, IL Farmaco, 60, 291 (2005); doi:10.1016/j.farmac.2005.01.010.

V.P. Devmurari, M.B. Goyani, R.R. Nandanwar and S. Pandey, Int. J. Chem. Tech. Res., 2, 681 (2010).

C.G. Mortimer, G. Wells, J.-P. Crochard, E.L. Stone, T.D. Bradshaw, M.F.G. Stevens and A.D. Westwell, J. Med. Chem., 49, 179 (2006); doi:10.1021/jm050942k.

B. Soni, M.S. Ranawat, R. Sharma, A. Bhandari and S. Sharma, Eur. J. Med. Chem., 45, 2938 (2010); doi:10.1016/j.ejmech.2010.03.019.

F.W. Bell, A.S. Cantrell, M. Hoegberg, S.R. Jaskunas, N.G. Johansson, C.L. Jordan, M.D. Kinnick, P. Lind and J.M. Morin, J. Med. Chem., 38, 4929 (1995); doi:10.1021/jm00025a010.

R.L. Mital and S.K. Jain, J. Chem. Soc. C, 2148 (1969); doi:10.1039/J39690002148.

W.C. Patt, H.W. Hamilton, M.D. Taylor, M.J. Ryan, D.G. Taylor, C.J.C. Connolly, A.M. Doherty, S.R. Klutchko and I. Sircar, J. Med. Chem., 35, 2562 (1992); doi:10.1021/jm00092a006.

M.T. Migawa, J.-L. Girardet, J.A. Walker, G.W. Koszalka, S.D. Chamberlain, J.C. Drach and L.B. Townsend, J. Med. Chem., 41, 1242 (1998); doi:10.1021/jm970545c.

B.S. Holla, K.V. Malini, B.S. Rao, B.K. Sarojini and N.S. Kumari, Eur. J. Med. Chem., 38, 313 (2003); doi:10.1016/S0223-5234(02)01447-2.

P.S. Yadav and G.P. Senthilkumar, Int. J. Pharm. Sci. Drug Res., 3, 1 (2011).

P. Meier, S. Legraverant, S. Müller and J. Schaub, Synthesis, 551 (2003); doi:10.1055/s-2003-37663.

National Committee for Clinical Laboratory Standards (NCCLS), Standard Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria, which Grows Aerobically; Approved standard—5th edn, Approved Standard NCCLS Document M7-A5. NCCLS: Wayne, PA (2003).

A. Kamal, M.N.A. Khan, K.S. Reddy, Y.V.V. Srikanth and B. Sridhar, Chem. Biol. Drug Des., 71, 78 (2008); doi:10.1111/j.1747-0285.2007.00609.x.

Issue

Vol. 27 No. 12 (2015): Vol 27 Issue 12

Design, Synthesis and Biological Evaluation of Benzimidazolyl and Benzothiazolyl Picolinamide Derivatives as Antimicrobial Agents

Corresponding Author(s) : B. Bharath Kumar Goud

Abstract

Keywords

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