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Vol. 27 No. 12 (2015): Vol 27 Issue 12

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Synthesis and Antiviral Activities of Some 2,3-Disubstituted Quinazoline Derivatives

https://doi.org/10.14233/ajchem.2015.19132
V.D. Gupta
Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala-133 207, India
Joginder Singh
Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala-133 207, India
Mayank Kinger
Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala-133 207, India
Avnish Kumar Arora
Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala-133 207, India
Vivek Sheel Jaswal
Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala-133 207, India

Corresponding Author(s) : V.D. Gupta

vishnugupta442@gmail.com

Asian Journal of Chemistry, Vol. 27 No. 12 (2015): Vol 27 Issue 12

Abstract

In the search of new leads towards potent antiviral agents 2,3-disubstituted quinazoline derivatives were synthesized and tested for their antiviral activity. Anthranilic acid (1) on treatment with an aromatic acid chloride in pyridine gives 2-aryl-4-oxo-3H-benzoxazines (2) which in turn reacts with p-amino benzoic acid (PABA) to afford 2-aryl-3-p-carboxylatophenyl-4-oxo-3H-quinazolines (3). The compound 3 further reacts with amido alcohols in the presence of conc. H2SO4 resulting 3-[benzoic acid-(3-phthalimidomethyl/3-ethyl-3H-2-phenyl-4-oxo-quinazolinyl/1-ethyl-7-hydroxy-4-methyl-2-oxo-quinolinyl)]-2-aryl-3H-quinazoline-4-ones (4). The resulting compounds 4a-f have been evaluated for their in vitro and in vivo antiviral activity against JEV and HSV type-I. The synthesized compounds were characterized through their physical and chemical analysis. The obtained results can be used as the key step for the building of novel chemical entities with interesting antiviral activity compare with the standard drugs.

Keywords

Antiviral activities 2 3-Disubstituted quinazoline derivatives
Gupta, V., Singh, J., Kinger, M., Kumar Arora, A., & Sheel Jaswal, V. (2015). Synthesis and Antiviral Activities of Some 2,3-Disubstituted Quinazoline Derivatives. Asian Journal of Chemistry, 27(12), 4379–4382. https://doi.org/10.14233/ajchem.2015.19132
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