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Vol. 27 No. 11 (2015): Vol 27 Issue 11

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Synthesis of Naphthoquinone Dendrimer Based Materials as Potential Antimalarial Drugs

https://doi.org/10.14233/ajchem.2015.19087
T. Ndior
Laboratoire de Chimie & Biochimie des Produits Naturels, Département de Chimie, Faculté des Sciences et Techniques, Université Cheikh Anta DIOP de Dakar, Dakar, Sénégal
C.M. Ndiaye
Laboratoire de Chimie & Biochimie des Produits Naturels, Département de Chimie, Faculté des Sciences et Techniques, Université Cheikh Anta DIOP de Dakar, Dakar, Sénégal
F.D. Faye
Laboratoire de Chimie & Biochimie des Produits Naturels, Département de Chimie, Faculté des Sciences et Techniques, Université Cheikh Anta DIOP de Dakar, Dakar, Sénégal
A. Samb
Laboratoire de Chimie & Biochimie des Produits Naturels, Département de Chimie, Faculté des Sciences et Techniques, Université Cheikh Anta DIOP de Dakar, Dakar, Sénégal

Corresponding Author(s) : C.M. Ndiaye

elhcheikhm.ndiaye@ucad.edu.sn

Asian Journal of Chemistry, Vol. 27 No. 11 (2015): Vol 27 Issue 11

Abstract

The synthesis of two new PPI-G1 dendrimers containing lawsone (2-hydroxy-p-naphthoquinone) as pharmacophore is reported. The compounds were synthesized in course of Mannich reaction involving lawsone, the commercial PPI-G1 (polypropyleneimine-G1) dendrimer with functional amino groups on the exterior and acetaldehyde (1) or benzaldehyde (2) in 4:1:4 molar ratio. Their structures are authenticated via FT-IR, 1H and 13C{1H} NMR and mass spectra.

Keywords

Dendrimer Polypropyleneimine Naphthoquinone Mannich Antimalarial
Ndior, T., Ndiaye, C., Faye, F., & Samb, A. (2015). Synthesis of Naphthoquinone Dendrimer Based Materials as Potential Antimalarial Drugs. Asian Journal of Chemistry, 27(11), 4063–4066. https://doi.org/10.14233/ajchem.2015.19087
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