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Vol. 27 No. 10 (2015): Vol 27 Issue 10

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Kinetics of Oxidation of Atropine by Alkaline KMnO4 in Aqueous Solutions

https://doi.org/10.14233/ajchem.2015.19039
Abdullah I. Saleh
The Hashemite University, Department of Chemistry, Faculty of Science, P.O. Box 330127, Zarqa 13133, Jordan
Sanad K. Al-Ghreizat
The Hashemite University, Department of Chemistry, Faculty of Science, P.O. Box 330127, Zarqa 13133, Jordan
Hamzeh M. Abdel-Halim
The Hashemite University, Department of Chemistry, Faculty of Science, P.O. Box 330127, Zarqa 13133, Jordan

Corresponding Author(s) : Abdullah I. Saleh

a-saleh@hu.edu.jo

Asian Journal of Chemistry, Vol. 27 No. 10 (2015): Vol 27 Issue 10

Abstract

Kinetics of oxidation of atropine by alkaline KMnO4 has been studied in aqueous solutions at various temperatures. Kinetic measurements were performed at constant pH and constant ionic strength, under pseudo-first order condition in which the concentration of atropine was around an order of magnitude greater than that of KMnO4. The observed rate constant was obtained by following the change in absorbance of the reaction mixture with time at a predetermined wavelength. The overall rate constant and the orders of the reaction with respect to concentrations of both atropine and KMnO4 were determined. Two observed rates and hence, two rates constant were found. This indicates that the oxidation process occurs in two steps with the formation of intermediates. A suggested mechanism for the reaction is given which agrees with kinetics results. The activation energy of the process was convoluted from temperature effect on the rate of the reaction.

Keywords

Kinetics Atropine Potassium permanganate Anticholinergic
I. Saleh, A., K. Al-Ghreizat, S., & M. Abdel-Halim, H. (2015). Kinetics of Oxidation of Atropine by Alkaline KMnO4 in Aqueous Solutions. Asian Journal of Chemistry, 27(10), 3877–3882. https://doi.org/10.14233/ajchem.2015.19039
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