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Vol. 27 No. 10 (2015): Vol 27 Issue 10

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Synthesis, Characterization and Antibacterial Activity of Some New 3-{[4-(2-Methoxyphenyl)piperazin-1-yl]sulfonyl}benzohydrazide-hydrazone Derivatives

https://doi.org/10.14233/ajchem.2015.18945
Srinivasa Rao Yatcherla
Department of Chemistry, Acharya Nagarjuna University, Guntur-522 510, India
Aminul Islam
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad-502 329, India
D. Nageswar
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad-502 329, India
B. Hari Babu
Department of Chemistry, Acharya Nagarjuna University, Guntur-522 510, India

Corresponding Author(s) : Srinivasa Rao Yatcherla

yatcherlasrinivasarao@gmail.com

Asian Journal of Chemistry, Vol. 27 No. 10 (2015): Vol 27 Issue 10

Abstract

In this article, a series of novel derivatives of 3-{[4-(2-methoxyphenyl)piperazin-1-yl]sulfonyl}benzohydrazide have been reported. The structures of all compounds have been evaluated by elemental analysis and spectral analysis (IR, MS and 1H NMR). All the compounds have been screened for antimicrobial activity against two Gram-positive bacteria viz., Staphylococcus aureus and Staphylococcus pyogenes, two Gram-negative bacteria viz., Escherichia coli and Pseudomonas aeruginosa. Compounds 6g (R = 4-NO2) and 6h (R = 2-OH, 3-OMe) exhibited excellent antibacterial activity, while the compounds 6a (R = H), 6b (R = 2-OMe), 6f (R = 4-OMe), 6i (R = 3,4-diethoxy) and 6j (R = 3-OMe, 4-OEt) displayed good antibacterial activity.

Keywords

1-(2-Methoxyphenyl)piperazine 3-(Chlorosulfonyl)benzoic acid Hydrazones Antibacterial activity Synthesis Ciprofloxacin
Rao Yatcherla, S., Islam, A., Nageswar, D., & Hari Babu, B. (2015). Synthesis, Characterization and Antibacterial Activity of Some New 3-{[4-(2-Methoxyphenyl)piperazin-1-yl]sulfonyl}benzohydrazide-hydrazone Derivatives. Asian Journal of Chemistry, 27(10), 3729–3733. https://doi.org/10.14233/ajchem.2015.18945
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