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Vol. 35 No. 5 (2023): Vol 35 Issue 5, 2023

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Design, Synthesis and Characterization of Novel 1H-1,2,3-Triazole Quinoline-Isatin Tethered Conjugates

https://doi.org/10.14233/ajchem.2023.27873
Ravi Kant
1Chemistry Discipline, School of Sciences, Indira Gandhi National Open University, New Delhi-110068, India 2Department of Chemistry, Government Post Graduate College, Noida-201301, India
https://orcid.org/0000-0002-1985-8686
Keshav Kumar Saini
3Department of Chemistry, Dyal Singh College, University of Delhi, Lodhi Road, New Delhi-110003, India 4Department of Chemistry, University of Delhi, Delhi-110007, India
https://orcid.org/0000-0002-2575-6731
Ravindra Kumar Upadhyay
4Department of Chemistry, University of Delhi, Delhi-110007, India 5Department of Chemistry, Sri Venkateswara College, University of Delhi, Dhaula Kuan, New Delhi-110021, India
https://orcid.org/0009-0001-5541-1187
Nasser Amri
Department of Chemistry, Faculty of Science, Jazan University, P.O. Box 2097, Jazan 45142, Saudi Arabia
Rakesh Kumar
Department of Chemistry, University of Delhi, Delhi-110007, India
https://orcid.org/0000-0001-9613-4764
Lalita S. Kumar
Chemistry Discipline, School of Sciences, Indira Gandhi National Open University, New Delhi-110068, India
https://orcid.org/0000-0003-4828-7664

Corresponding Author(s) : Lalita S. Kumar

lalitaskumar@ignou.ac.in

Asian Journal of Chemistry, Vol. 35 No. 5 (2023): Vol 35 Issue 5, 2023

Abstract

Quinoline is an important heterocyclic scaffold which is found in a variety of natural compounds (cinchona alkaloids) and therapeutically active drugs with various biological functions. Because of its varied chemical and pharmacological characteristics, quinoline and its derivatives have long drawn the attention of both synthetic and biological chemists. A newer class of quinoline-isatin tethered 1,2,3-triazole conjugates was synthesized in this context, using copper-promoted click chemistry with various organic systems. Ten derivatives of 1,2,3-triazole-tethered 8-hydroxyquinoline and 5-chloro-8-hydroxyquinoline derivatives of isatin were synthesized and well characterized by using analytical techniques such as mass spectrometry, IR, 1H NMR and 13C NMR spectroscopy.

Keywords

Quinolines 1,2,3-Triazoles Isatin Design Synthesis Click reaction
Kant, R., Saini, K. K., Upadhyay, R. K., Amri, N., Kumar, R., & Kumar, L. S. (2023). Design, Synthesis and Characterization of Novel 1H-1,2,3-Triazole Quinoline-Isatin Tethered Conjugates. Asian Journal of Chemistry, 35(5), 1269–1275. https://doi.org/10.14233/ajchem.2023.27873
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