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Vol. 35 No. 5 (2023): Vol 35 Issue 5, 2023

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An Efficient, One-Pot Synthesis of 1,3-Disubstituted imidazo[1,5-a]pyridines, Fe(OTf)3 Mediated C-C Bond Formation

https://doi.org/10.14233/ajchem.2023.27602
T.C. Raveesha
Department of Post Graduate Studies and Research in Polymer Science, Sir M Visvesvaraya Post Graduate Centre, Tubinakere, Mandya-571402, India
https://orcid.org/0009-0005-4991-4860
Kemparajegowda
Department of Studies in Chemistry, Muktagangotri, Karnataka State Open University, Mysuru-570006, India
https://orcid.org/0000-0003-1313-0886
Hassan A. Swarup
Department of Chemistry, BNM Institute of Technology, Bengaluru-560070, India
https://orcid.org/0000-0003-3532-2352
B.K. Kempegowda
Department of Chemistry, Government First Grade College, Nanjangud-571301, India
https://orcid.org/0009-0006-5704-3775
T. Demappa
Department of Post Graduate Studies and Research in Polymer Science, Sir M Visvesvaraya Post Graduate Centre, Tubinakere, Mandya-571402, India
https://orcid.org/0000-0003-0948-4294

Corresponding Author(s) : T. Demappa

tdemappa2003@yahoo.co.in

Asian Journal of Chemistry, Vol. 35 No. 5 (2023): Vol 35 Issue 5, 2023

Abstract

A vital approach of Fe(OTf)3 and MS3Å (molecular sieves 3Å) mediated one pot synthesis of 1,3-disubstituted imidazo[1,5-a]pyridines from dithioester, 2-methylaminopyridine and alcohol. This methodology involves the intramolecular cyclization and C–C bond formation under mild condition and operates in a single step yielding the products in good to excellent yields. This protocol was compatible to construct various 1,3-disubstituted imidazo[1,5-a] pyridines derivatives.

Keywords

C-C bond formation Benzhydrol 1,3-Disubstituted imidazo[1,5-a]pyridine Fe(OTf)3 T3P
Raveesha, T., Kemparajegowda, ., Swarup, H. A., Kempegowda, B., & Demappa, T. (2023). An Efficient, One-Pot Synthesis of 1,3-Disubstituted imidazo[1,5-a]pyridines, Fe(OTf)3 Mediated C-C Bond Formation. Asian Journal of Chemistry, 35(5), 1225–1230. https://doi.org/10.14233/ajchem.2023.27602
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