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Vol. 35 No. 5 (2023): Vol 35 Issue 5, 2023

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A Catalyst Free and Sustainable Synthesis of Quinazolinones in Glycerol as Green Solvent

https://doi.org/10.14233/ajchem.2023.27612
Gaurav Prakash
Department of Chemistry, M.L.T. College (Constituent unit of B.N. Mandal University, Madhepura), Saharsa-852201, India
Ajay Kumar Das
Department of Chemistry, M.L.T. College (Constituent unit of B.N. Mandal University, Madhepura), Saharsa-852201, India
V.D. Tripathi
Department of Chemistry, C.M. Science College (Constituent unit of L.N. Mithila University, Darbhanga), Darbhanga-846004, India
https://orcid.org/0000-0003-2802-0292

Corresponding Author(s) : V.D. Tripathi

vdtmkclnmu@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 5 (2023): Vol 35 Issue 5, 2023

Abstract

In this article, glycerol was employed in a quest to develop an environmentally benign and sustainable synthetic protocol for synthesis of quinazolinone and spiro-quinazolinone derivatives. These studies were performed to investigate the effect of electron-rich and electronegative groups on the synthetic route of an established protocol. Different substituted isatin and benzaldehyde derivatives have been incorporated to synthesize analogues of two series of quinazolinones in order to investigate the efficacy of the developed methodology and substrate tolerance. A total of 12 derivatives were synthesized and characterized by spectroscopic techniques.

Keywords

Quinazolinones Spiro Green chemistry Glycerol Sustainable
Prakash, G., Das, A. K., & Tripathi, V. (2023). A Catalyst Free and Sustainable Synthesis of Quinazolinones in Glycerol as Green Solvent. Asian Journal of Chemistry, 35(5), 1089–1094. https://doi.org/10.14233/ajchem.2023.27612
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