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Synthesis and Biological Studies of Novel Coumarin Derivatives Comprising Azo Functional Group
Asian Journal of Chemistry,
Vol. 29 No. 1 (2017): Vol 29 Issue 1
Abstract
Some novel coumarin derivatives have been synthesized by diazotization of 4-aminoacetophenone and subsequent coupling reaction with salicylaldehyde and further treatment of obtained product with various active methelene compounds. The structures of compounds are confirmed by IR, NMR, GC-MS spectra and evaluated their antimicrobial activity by using disc diffusion method.
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- G. Slapsytë, V. Dedonytë, J.R. Lazutka, J. Mierauskienë, V. Morkunas, R. Kazernaviciutë, A. Pukalskas and P.R. Venskutonis, Molecules, 18, 4419 (2013).
- I. Manolov and N.D. Danchev, Eur. J. Med. Chem. Chim. Ther., 30, 531 (1995).
- Z.M. Nofal, M.I. El-Zahar and S.S. Abd El-Karim, Molecules, 5, 99 (2000).
- L. Raev, E. Voinov, I. Ivanov and D. Popov, Pharmazie, 45, 696 (1990).
- K. Babu, D. Selvi and P. Pitchai, Der Pharma Chemica, 7, 89 (2015).
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References
O. Kennedy and R. Zhorenes, in eds.: R. O’Kennedy and R.D. Thornes, Coumarins: Biology, Applications and Mode of Action; John Wiley & Sons: Chichester, UK (1997).
P. Chiu, L.T. Leung and C.B.B. Ko, Nat. Prod. Rep., 27, 1066 (2010).
(a) V. Boucard, G. Broustal and J.M. Campagne, Eur. J. Org. Chem., 225 (2007); (b) G.J. Florence, N.M. Gardner and I. Paterson, Nat. Prod. Rep., 25, 342 (2008).
D. Jansone, L. Leite, M. Fleisher, J. Popelis, I. Mazheika, E. Lukevics, G. Melikyan and A. Ayetisvan, Khim. Geterotsikl. Soedin., 3, 298 (1998).
L.X. Yang, H.B. Li, X.M. Wu, H. Bai, Q.J. Zhang and Y. Zhao, Chin. Chem. Lett., 16, 1189 (2005).
Y. Dong, K. Nakagawa-Goto, C. Lai, S. Morris-Natschke, K. Bastow and K. Lee, Bioorg. Med. Chem. Lett., 20, 4085 (2010).
B.C. Raju, A.K. Tiwari, J.A. Kumar, A.Z. Ali, S.B. Agawane, G. Saidachary and K. Madhusudana, Bioorg. Med. Chem., 18, 358 (2010).
H.M. Bilgin, M. Atmaca, B.D. Obay, S. Ozekinci, E. Tasdemir and A. Ketani, Exp. Toxicol. Pathol., 63, 325 (2011).
G. Slapsytë, V. Dedonytë, J.R. Lazutka, J. Mierauskienë, V. Morkunas, R. Kazernaviciutë, A. Pukalskas and P.R. Venskutonis, Molecules, 18, 4419 (2013).
I. Manolov and N.D. Danchev, Eur. J. Med. Chem. Chim. Ther., 30, 531 (1995).
Z.M. Nofal, M.I. El-Zahar and S.S. Abd El-Karim, Molecules, 5, 99 (2000).
L. Raev, E. Voinov, I. Ivanov and D. Popov, Pharmazie, 45, 696 (1990).
K. Babu, D. Selvi and P. Pitchai, Der Pharma Chemica, 7, 89 (2015).
K. Babu, P. Pitchai and R.M. Gengan, J. Chem. Pharm. Res., 7, 275 (2015).
K. Babu, P. Pitchai, M. Sathiyaseelan and A. Nepolraj, Der Pharma Chemica, 7, 95 (2015).