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Vol. 35 No. 3 (2023): Vol 35 Issue 3

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Submitted
Feb 28, 2023
Published
Feb 27, 2023

Synthesis of Novel Isoxazoline/Isoxzolyl Pyrano Heterocyclic Annulated Flavones

Rachakonda Sydhulua
Department of Chemistry, Nizam College, Osmania University, Hyderabad-500001, India
Yerrabelly Hemasria
hemay2@yahoo.com
Department of Chemistry, Nizam College, Osmania University, Hyderabad-500001, India

Corresponding Author(s) : Yerrabelly Hemasria

hemay2@yahoo.com

Asian Journal of Chemistry, Vol. 35 No. 3 (2023): Vol 35 Issue 3 page 624-628

Abstract

The synthesis of new isoxazoline/isoxazole pyrano fused flavone derivatives from 6-hydroxy 5-formyl flavone via in situ generation of nitrile oxide from aldoxime using ceric ammonium nitrate (CAN) as an oxidant followed by intramolecular cycloaddition reaction at olefin/alkyne functions is reported in high yields. The reaction involves regio selective annulation at C5/C6 position in preference to the C6/C7 position of flavones. All the synthesized compounds were successfully characterized by IR, 1H NMR, 13C NMR and ESI-MS.

Keywords

Flavone aldoximes Flavone-isoxazoline/isoxazole Ceric ammonium nitrate 1,3-Dipolar cycloaddition
SydhuluaR., & HemasriaY. (2023). Synthesis of Novel Isoxazoline/Isoxzolyl Pyrano Heterocyclic Annulated Flavones. Asian Journal of Chemistry, 35(3), 624-628. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/27760
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