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Vol. 35 No. 2 (2023): Vol 35 Issue 2, 2023

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Design, Synthesis and Anti-tubercular Evaluation of Some Novel Chroman-Hydrazone Derivatives

https://doi.org/10.14233/ajchem.2023.27002
Samar Mujeeb
Department of Pharmaceutical Chemistry, Hygia Institute of Pharmaceutical Education & Research, Lucknow-226020, India
Kuldeep Singh
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Integral University, Lucknow-226021, India
Bhumika Yogi
Department of Pharmaceutical Chemistry, Hygia Institute of Pharmaceutical Education & Research, Lucknow-226020, India
Praveen Kumar
Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Saifai-206130, Etawah, India
Piyush Kumar
Department of Chemistry, Indian Institute of Technology, Jammu, Jagti, NH-44, Nagrota, Jammu-181221, India

Corresponding Author(s) : Kuldeep Singh

kuldeep@iul.ac.in

Asian Journal of Chemistry, Vol. 35 No. 2 (2023): Vol 35 Issue 2, 2023

Abstract

The molecular docking, synthesis, spectral characterization and anti-tubercular evaluation of 10 novel N’-substituted-6-hydroxy-2,5,7,8-tetramethylchroman-2-carbohydrazide derivatives (SM1-SM10) were reported. The structures of the synthesized derivatives were affirmed by spectroscopic studies such as FTIR, 1H NMR, 13C NMR and high resolution-mass spectrometry. Predicted ADME and toxicity investigations were accomplished to presume the pharmacokinetic parameters of the compounds. The synthesized compounds were evaluated for in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv strain using Microplate Alamar Blue Assay (MABA) taking isoniazid, rifampicin, ethambutol, amikacin, streptomycin and levofloxacin as positive drug standards. Compound SM8 has shown the significant anti-tubercular activity among all the titled compounds. The results indicated that chroman-hydrazone skeleton could serve as a lead for the development of novel anti-tubercular drugs.

Keywords

Anti-tubercular activity Coumarin hydrazone Hybrid derivatives
Mujeeb, S., Singh, K., Yogi, B., Kumar, P., & Kumar, P. (2023). Design, Synthesis and Anti-tubercular Evaluation of Some Novel Chroman-Hydrazone Derivatives. Asian Journal of Chemistry, 35(2), 483–492. https://doi.org/10.14233/ajchem.2023.27002
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