Issue

Vol. 29 No. 1 (2017): Vol 29 Issue 1

Copyright (c) 2017 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Fungicidal Activity of Bioactive 4,4'-bis[4"-(N-Benzylidinylamine)-3"-mercapto-1",2",4"-triazole-5"-yl methoxy]dibenzyl

https://doi.org/10.14233/ajchem.2017.20097
Smriti Dwivedi1
1Department of Chemistry, Galgotia College of Engineering and Technology, Greater Noida-201 306, India 2Food Analysis and Research Lab, Centre of Food Technology, University of Allahabad, Allahabad-211 002, India *Corresponding author: E-mail: smriti96@rediffmail.com
Pravin K. Singh2
1Department of Chemistry, Galgotia College of Engineering and Technology, Greater Noida-201 306, India 2Food Analysis and Research Lab, Centre of Food Technology, University of Allahabad, Allahabad-211 002, India *Corresponding author: E-mail: smriti96@rediffmail.com

Asian Journal of Chemistry, Vol. 29 No. 1 (2017): Vol 29 Issue 1

Abstract

The reaction of 4,4'-diamino dibenzyl (I) with sodium nitrite and HCl at 0-5 °C followed by hydrolysis gave 4,4'-dihydroxy dibenzyl (II), which on reaction with chloroacetic acid in presence of sodium carbonate yielded 4,4'-ethylenebisphenoxyacetic acid (III). Nucleophilic substitution of compound III with hydrazine hydrate gave 4,4'-bis(methoxycarbohydrazide)dibenzyl (IV) which on condensation with CS2 and KOH gave 4'4-bis-[(3"-mercapto-1",2",4"-oxadiazole-5"-yl)methoxy]dibenzyl (V). Compound V further condensed with hydrazine hydrate and yielded 4’4-bis[4"-amino-3"-mercapto-1",2",4"-triazole-5"yl methoxy]dibenzyl (VI). It on condensation with different carbonyl compounds gave 4,4’-bis[4"-(N-benzylidinylamine)-3"-mercapto-1",2",4"-triazole-5"yl methoxy]dibenzyl (VIIa-h). Compounds (VIIa-h) were evaluated in vitro for their fungi toxicities against Aspergillus niger and Fusarium oxysporum.

Keywords

Dibenzyl Triazole Fungitoxicities Aspergillus niger Fusarium oxysporum.
Dwivedi1, S., & K. Singh2, P. (2016). Synthesis and Fungicidal Activity of Bioactive 4,4’-bis[4"-(N-Benzylidinylamine)-3"-mercapto-1",2",4"-triazole-5"-yl methoxy]dibenzyl. Asian Journal of Chemistry, 29(1), 19–21. https://doi.org/10.14233/ajchem.2017.20097
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. Y. Asakawa, M. Tori, K. Takikawa, H.G. Krishnamurty and S.K. Kar, Phytochemistry, 26, 1811 (1987).
  2. T. Hashimoto, M. Tori and Y. Asakawa, Phytochemistry, 27, 109 (1988).
  3. U.V. Laddi, S.R. Desai, Y.S. Somannavar, R.S. Bennur and S.C. Bennur, Indian J. Chem., 37B, 461(1998).
  4. M.B. Talawar, S.R. Desai, Y.S. Somannavar, S.C. Marihal and S.C. Bennur, Indian J. Heterocycl. Chem., 5, 215 (1996).
  5. A.L. Barry, The Antimicrobic Susceptibility Test, Principle and Practices, ELBS, London, edn 4, (1976).
  6. I.R. Siddiqui, J. Singh, P.K. Singh, S. Dwivedi, P.K. Shukla and J. Singh, Indian J. Heterocycl. Chem., 14, 231 (2005).
  7. I.R. Siddiqui, J. Singh, P.K. Singh and J. Singh, Indian J. Chem., 44B, 1460 (2005).
  8. I.R. Siddiqui, P.K. Singh, J. Singh and J. Singh, Indian J. Chem., 44B, 2102 (2005).
  9. P.K. Singh and I.R. Siddiqui, Indian J. Chem., 48B, 1013 (2009).
  10. I.R. Siddqui and S. Dwivedi, J. Indian Chem. Soc., 86, 149 (2009).
  11. I.R. Siddiqui, S. Dwivedi, P.K. Shukla, S. Jaiswal and N.A. Siddiqui, J. Indian Chem. Soc., 83, 89 (2006).
  12. I.R. Siddiqui, S. Dwivedi, A. Srivastava, P.K. Shukla and P.K. Singh, Indian J. Heterocycl. Chem., 14, 251 (2005).
  13. I.R. Siddiqui, P.K. Singh, J. Singh and J. Singh, J. Agric. Food Chem.,51, 7062 (2003).
  14. C.R. Fuson and H.O. House, J. Am. Chem. Soc., 75, 1325 (1953).
  15. J.G. Horsfall, Bot. Rev., 11, 357 (1945).
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 0