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Vol. 30 No. 8 (2018): Vol 30 Issue 8

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Synthesis, in vitro and Molecular Docking Studies of 1-(3,4-Dimethoxy-phenyl)-5-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one as New Potential Anti-inflammatory

https://doi.org/10.14233/ajchem.2018.21297
Mario Rowan Sohilait1
1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Pattimura University, Jl.Ir.M. Putuhena, Kampus Poka, Ambon 97233, Indonesia 2Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Jl. Sekip Utara, Yogyakarta 55281, Indonesia *Corresponding author: E-mail: rio.rowan@gmail.com
Harno Dwi Pranowo2
1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Pattimura University, Jl.Ir.M. Putuhena, Kampus Poka, Ambon 97233, Indonesia 2Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Jl. Sekip Utara, Yogyakarta 55281, Indonesia *Corresponding author: E-mail: rio.rowan@gmail.com
Winarto Haryadi2
1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Pattimura University, Jl.Ir.M. Putuhena, Kampus Poka, Ambon 97233, Indonesia 2Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Jl. Sekip Utara, Yogyakarta 55281, Indonesia *Corresponding author: E-mail: rio.rowan@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 8 (2018): Vol 30 Issue 8

Abstract

Synthesis of new asymmetrical curcumin analogue of 1-(3,4-dimethoxy-phenyl)-5-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one via condensation reaction between vanillinacetone and veratraldehyde in ethanol has been performed. The in vitro anti-inflammatory activities of the synthesized compounds showed excellent anti-inflammatory activity. In vitro anti-inammatory activity by using inhibition of albumin denaturation technique compared to standard dichlorofenac. Molecular docking studies were performed, where docking of the compound into 6COX active site suggested that it could exert its anti-inflammatory potential by cyclooxygenase inhibition.

Keywords

Curcumin analogues Anti-inflammatory Molecular docking Synthesis in vitro.
Rowan Sohilait1, M., Dwi Pranowo2, H., & Haryadi2, W. (2018). Synthesis, in vitro and Molecular Docking Studies of 1-(3,4-Dimethoxy-phenyl)-5-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one as New Potential Anti-inflammatory. Asian Journal of Chemistry, 30(8), 1765–1770. https://doi.org/10.14233/ajchem.2018.21297
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