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Vol. 30 No. 8 (2018): Vol 30 Issue 8

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Isolation of Steroid Compounds from Suruhan (Peperomia pellucida L. Kunth) and Their Antimalarial Activity

https://doi.org/10.14233/ajchem.2018.21285
Nurhayati Bialangi1
1Department of Chemistry, Faculty of Mathematic and Natural Sains, State University of Gorontalo, Gorontalo 96128, Indonesia 2Department of Pharmacy, Faculty of Sport and Healthy, State University of Gorontalo, Gorontalo 96128, Indonesia 3Department of Chemistry, Faculty of Mathematics and Natural Sains, Tanjungpura University, Kota Pontianak, Kalimantan Barat 78115, Indonesia 4Department of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Banten 42411, Indonesia *Corresponding author: E-mail: boimatumeang@gmail.com
Adam Mustapa2
1Department of Chemistry, Faculty of Mathematic and Natural Sains, State University of Gorontalo, Gorontalo 96128, Indonesia 2Department of Pharmacy, Faculty of Sport and Healthy, State University of Gorontalo, Gorontalo 96128, Indonesia 3Department of Chemistry, Faculty of Mathematics and Natural Sains, Tanjungpura University, Kota Pontianak, Kalimantan Barat 78115, Indonesia 4Department of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Banten 42411, Indonesia *Corresponding author: E-mail: boimatumeang@gmail.com
Yusda Salimi1
1Department of Chemistry, Faculty of Mathematic and Natural Sains, State University of Gorontalo, Gorontalo 96128, Indonesia 2Department of Pharmacy, Faculty of Sport and Healthy, State University of Gorontalo, Gorontalo 96128, Indonesia 3Department of Chemistry, Faculty of Mathematics and Natural Sains, Tanjungpura University, Kota Pontianak, Kalimantan Barat 78115, Indonesia 4Department of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Banten 42411, Indonesia *Corresponding author: E-mail: boimatumeang@gmail.com
Ari Widiantoro3
1Department of Chemistry, Faculty of Mathematic and Natural Sains, State University of Gorontalo, Gorontalo 96128, Indonesia 2Department of Pharmacy, Faculty of Sport and Healthy, State University of Gorontalo, Gorontalo 96128, Indonesia 3Department of Chemistry, Faculty of Mathematics and Natural Sains, Tanjungpura University, Kota Pontianak, Kalimantan Barat 78115, Indonesia 4Department of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Banten 42411, Indonesia *Corresponding author: E-mail: boimatumeang@gmail.com
Boima Situmeang4
1Department of Chemistry, Faculty of Mathematic and Natural Sains, State University of Gorontalo, Gorontalo 96128, Indonesia 2Department of Pharmacy, Faculty of Sport and Healthy, State University of Gorontalo, Gorontalo 96128, Indonesia 3Department of Chemistry, Faculty of Mathematics and Natural Sains, Tanjungpura University, Kota Pontianak, Kalimantan Barat 78115, Indonesia 4Department of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Banten 42411, Indonesia *Corresponding author: E-mail: boimatumeang@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 8 (2018): Vol 30 Issue 8

Abstract

Suruhan (Peperomia pellucida) is easily found in Indonesia and has the potential of being a herb medicine. General phytochemical screening revealed the presence of flavonoid, steroid, triterpenoid, alkaloid and tannin compounds. Two steroid compounds were isolated from ethyl acetate fraction of the Peperomia pellucida. The compounds were isolated with chromatography method and antimalarial activity test with Desjardin method. Based on the spectral evidence IR, 1H NMR, 13C NMR, 2D NMR and MS spectroscopies, structures were determined to be stigmasterol (1) and fucosterol (2). The results of antimalarial activity test showed IC50 value of stigmasterol is 5.24 ppm and fucosterol is 0.85 ppm. This is the first report so far of isolation of steroid compounds from Peperomia pellucida plant from Gorontalo, Indonesia and their antimalarial activity test.

Keywords

Suruhan Steroid Antimalarial Peperomia pellucida.
Bialangi1, N., Mustapa2, A., Salimi1, Y., Widiantoro3, A., & Situmeang4, B. (2018). Isolation of Steroid Compounds from Suruhan (Peperomia pellucida L. Kunth) and Their Antimalarial Activity. Asian Journal of Chemistry, 30(8), 1751–1754. https://doi.org/10.14233/ajchem.2018.21285
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References
  1. M.S. Yusuf, I. Wulandari, L. Amelia and A. Katrin, J. Pharmacogn., 9, 239 (2017); https://doi.org/10.5530/pj.2017.2.40.
  2. M. Habsah, A. Yosie, K. Baker, C.C. Siang, D.F. Syamsumir, A. Alias and S.A.M. Radzi, J. Chem. Pharm. Res., 7, 578 (2015).
  3. G.M.D.P. Cera, N.R.B. Ramos and N.I.T. Siazon, J. Pharmacol., 143 (2011).
  4. P. Majumder, P. Abraham and V. Satya, Res. J. Pharm. Biol. Chem. Sci., 2, 358 (2011).
  5. A.K. Rahman and S. Islam, Turk. J. Biol., 32, 37 (2008).
  6. G.S. Singh and S. Pandeya, Nat. Prod. Med. Chem., 63, 101 (2011).
  7. N.R. Farnsworth, O. Akerele and A. Bingel, Bull. World Health Organ., 63, 965 (1985).
  8. C.R. Nwokocha, D.U. Owu, K. Kinlocke, J. Murray, R. Delgoda, K. Thaxter, G. McCalla and L. Young, Med. Aromat. Plants, 1, 105 (2012); https://doi.org/10.4172/2167-0412.1000105.
  9. R. Rojas-Martínez, J. Arrieta, L. Cruz-Antonio, D. Arrieta-Baez, A.M. Velázquez-Méndez and M.E. Sánchez-Mendoza, Molecules, 18, 11327 (2013); https://doi.org/10.3390/molecules180911327.
  10. Y. Susilawati, R. Nugraha, A. Muhtadi, S. Soetardjo and U. Supratman, Molbank, 2015, M855 (2015); https://doi.org/10.3390/M855.
  11. N. Bialangi, M. Mustapa, Y. Salimi, A. Widiantoro and B. Situmeang, J. Pendidikan Kimia, 8, 33 (2016).
  12. J.B. Harborne, Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis, Chapman and Hall, London, edn 3, pp. 129-138 (1998).
  13. M.S. Zaridah, M.A. Azah and A. Rohani, J. Trop. For. Sci., 18, 74 (2006).
  14. H. Overgaard, P. Sirisopa, B. Mikolo, K. Malterud, H. Wangensteen, Y.-F. Zou, B. Paulsen, D. Massamba, S. Duchon, V. Corbel and F. Chandre, Molecules, 19, 21276 (2014); https://doi.org/10.3390/molecules191221276.
  15. S.H. Hwang, J.M. Jang and S.S. Lim, Fish. Aquat. Sci., 15, 191 (2012); https://doi.org/10.5657/FAS.2012.0191.
  16. Y. Ahmed, S. Rahman, P. Akhtar, F. Islam, M. Rahman and Z. Yakoob, Int. Food Res. J., 20, 2939 (2013).
  17. R. Nasution, T. Barus, P. Nasution and N. Saidi, Int. J. Pharm. Tech. Res., 6, 1279 (2014).
  18. L.L. Pierre and M.N.J Moses, J. Innov. Pharm. Biol. Sci., 2, 88 (2015).
  19. U. Kolak, G. Topcu, S. Birteqsiz, G. Otuk and A. Ulubele, Turk. J. Chem., 209, 177 (2005).
  20. A. Kamboj and A.K. Saluja, Int. J. Pharm. Sci., 3, 94 (2014).
  21. P.S. Jain and S.B. Bari, Asian J. Plant Sci., 9, 163 (2010); https://doi.org/10.3923/ajps.2010.163.167.
  22. V.S.P. Chaturvedula and I. Prakash, Int. Curr. Pharm. J., 1, 239 (2012); https://doi.org/10.3329/icpj.v1i9.11613.
  23. G. Prasanna and M. Chitra, Int. J. Pharmacog. Phytochem. Res., 7, 6 (2015); https://doi.org/10.5958/0975-4385.2015.00002.3.
  24. P.C. Trivedi and N. Choudrey, J. Pharm. Res., 4, 4252 (2001).
  25. I.I.-W. Kim, C.-K. Lee, H.S. Kim and S.-H. Jung, Arch. Pharm. Res., 26, 9 (2003); https://doi.org/10.1007/BF03179923.
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