Development of Efficient Manufacturing Process for Active Pharmaceutical Ingredient Epalrestat and its Derivatives in Continuous Flow Synthesis
Corresponding Author(s) : G. Veera Raghava Sharma
sganapav@gitam.edu
Asian Journal of Chemistry,
Vol. 35 No. 1 (2023): Vol 35 Issue 1 page 233-238
Abstract
An effective method for synthesis of the active pharmaceutical ingredient epalrestat in continuous or tubular flow circumstances with a high yield and a quick reaction time (10 min) has been reported. The reaction conditions for the aldol condensation reaction under tubular continuous flow technology by controlling light-sensitive degradation impurities was optimized. The developed method was more efficient, environmentally benign, time-economic, energy-saving, cost-efficient and also gives a reduction in process mass intensity in comparison with batch process.
Keywords
Aldol condensation
Process intensification
Continuous flow
Epalrestat
Kumar NaramsettiK., AlluriC., & Veera Raghava SharmaG. (2022). Development of Efficient Manufacturing Process for Active Pharmaceutical Ingredient Epalrestat and its Derivatives in Continuous Flow Synthesis. Asian Journal of Chemistry, 35(1), 233-238. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/27546
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References
- J. He, H.-X, Gao, N. Yang, X.-D. Zhu, R.-B. Sun, Y. Xie, C.-H. Zeng, J.-W. Zhang, J.-K. Wang, F. Ding, J.-Y. Aa and G.-J. Wang, Acta Pharmacol. Sin., 40, 86 (2019); https://doi.org/10.1038/s41401-018-0043-5
- L. Quattrini an M.C. La, Expert Opin. Ther. Pat., 29, 199 (2019); https://doi.org/10.1080/13543776.2019.1582646
- T. Tanouchi, M. Kawamura, A. Ajima, T. Mohri, M. Hayashi, H. Terashima, F. Hirata and T. Morimura, Rhodanine Derivatives, Process for their Preparation and Aldose Reductase Inhibitor containing the Rhodanine Derivatives as Active Gradient, US Patent 4464382A (1981).
- A.R. Bogdan and A.W. Dombrowski, J. Med. Chem., 62, 6422 (2019); https://doi.org/10.1021/acs.jmedchem.8b01760
- T.L. LaPorte, L. Spangler, M. Hamedi, P. Lobben, S.H. Chan, J. Muslehiddinoglu and S.S.Y. Wang, Org. Process Res. Dev., 18, 1492 (2014); https://doi.org/10.1021/op500176z
- J.P. McMullen, C.H. Marton, B.D. Sherry, G. Spencer, J. Kukura and N.S. Eyke, Org. Process Res. Dev., 22, 1208 (2018); https://doi.org/10.1021/acs.oprd.8b00192
- C. Hu, J. Flow Chem., 11, 243 (2021); https://doi.org/10.1007/s41981-021-00164-3
- A.R. Bogdan and A.W. Dombrowski, J. Med. Chem., 62, 6422 (2019); https://doi.org/10.1021/acs.jmedchem.8b01760
- S.L. Lee, T.F. O’Connor, X. Yang, S. Chatterjee, R.D. Madurawe, C.N. Cruz, C.M.V. Moore, L.X. Yu and J. Woodcock, J. Pharm. Innov., 10, 191 (2015); https://doi.org/10.1007/s12247-015-9215-8
- L. Zhou, S. Martin, W. Cheng, L. Lassabatere, J.-F. Boily and K. Hanna, Environ. Sci. Technol., 53, 10102 (2019); https://doi.org/10.1021/acs.est.9b03214
- M. Sun, J. Yang, Y. Fu, C. Liang, H. Li, G. Yan, C. Yin, W. Yu, Y. Ma, R. Cheng and J. Ye, Org. Process Res. Dev., 25, 1160 (2021); https://doi.org/10.1021/acs.oprd.0c00543
- B. Halford, C&EN, 95, 7 (2017); https://doi.org/10.1021/cen-09525-notw2
- M. Michida, H. Ishikawa, T. Kaneda, S. Tatekabe and Y. Nakamura, Org. Process Res. Dev., 23, 524 (2019); https://doi.org/10.1021/acs.oprd.8b00413