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Vol. 35 No. 1 (2023): Vol 35 Issue 1

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Submitted
Dec 30, 2022
Published
Dec 27, 2022

Synthesis and Anticancer Activity of Novel Thiazolo-Coumarin Derivatives

R. Swethan Babu
Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM IST Kattankulathur, Kancheepuram-603203, India
Senthilkumar Palaniappan
Faculty of Pharmacy, Karpagam Academy of Higher Education, Pollachi Main Road, Eachanari Post, Coimbatore-641021, India
M.K. Kathiravan
drmkkathir@gmail.com
Dr. A.P.J. Abdul Kalam Research Lab, SRM College of Pharmacy, SRM IST Kattankulathur, Kancheepuram-603203, India

Corresponding Author(s) : M.K. Kathiravan

drmkkathir@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 1 (2023): Vol 35 Issue 1 page 187-193

Abstract

As a starting point for creating new inhibitor scaffolds, a molecular hybridization approach was applied in designing the novel molecules using coumarin-thiazole hybrids as mPGES-1 enzyme inhibitors. Thus, in present work, the novel thiazolo coumarin derivatives (8-35) were synthesized and characterized by 1H NMR, IR and ESI-MS spectra. All the synthesized molecules (8-35) were also investigated for their anticancer activity on MCF-7 (breast cancer), caco-2 (colon cancer), HeLa (Cervix cancer) cell lines. Studies revealed that compounds (8-14) and (22-28) showed inhibition (IC50) at different concentrations of 12.5, 50, 100 μg/mL and more than 100 μg/mL.

Keywords

Thiazole Coumarin Cancer mPGES-1 inhibitors Molecular hybridization
Swethan BabuR., PalaniappanS., & KathiravanM. (2022). Synthesis and Anticancer Activity of Novel Thiazolo-Coumarin Derivatives. Asian Journal of Chemistry, 35(1), 187-193. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/27534
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