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Vol. 35 No. 1 (2023): Vol 35 Issue 1

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Microwave Assisted Synthesis and Evaluation of Anticonvulsant Activity of Some 3-(3-(Substituted benzylidine)amino)phenyl-2-phenylquinazolin-4(3H)-ones

https://doi.org/10.14233/ajchem.2023.26877
Dinesh Rishipathak
Department of Pharmaceutical Chemistry, MET’s Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik-422003, India
Chaitrali Karanjikar
Department of Pharmaceutical Chemistry, MET’s Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik-422003, India
Pavan Udavant
Department of Pharmacology, MET’s Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik-422003, India

Corresponding Author(s) : Dinesh Rishipathak

drishipathak@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 1 (2023): Vol 35 Issue 1

Abstract

Herein, the synthesis of 3-(3-(substituted benzylidine)amino)phenyl-2-phenylquinazolin-4(3H)-ones from 3-aminophenyl-2-phenyl-quinazolin-4(3H)-ones is reported. The chemical structures of the synthesized compounds were confirmed by FT-IR, 1H NMR and 13C NMR studies. All compounds were evaluated for their anticonvulsant activity against maximal electroshock seizure method. The LD50 value was found to be 550 mg/Kg and the duration of tonic phase was reduced upto 1.1 s and that of stupor phase was reduced upto 70 s. The structure activity relationship of the compounds revealed that Schiff bases viz. 3-(3-benzylidineamino)phenyl-2-phenylquinazolin-4(3H)-one, 3-(3-(3-chlorobenzylidine)amino)phenyl-2-phenylquinazolin-4(3H)-one, 3-(3-(3-nitrobenzylidine)amino)phenyl-2-phenylquinazolin-4(3H)-one by significantly shorten the tonic and stupor phases of convulsions compared to controls, thus thereby these compounds demonstrated strong anticonvulsant potential.

Keywords

4-(3H)-Quinazolinones Microwave Anticonvulsant Maximal electroshock seizures
Rishipathak, D., Karanjikar, C., & Udavant, P. (2022). Microwave Assisted Synthesis and Evaluation of Anticonvulsant Activity of Some 3-(3-(Substituted benzylidine)amino)phenyl-2-phenylquinazolin-4(3H)-ones. Asian Journal of Chemistry, 35(1), 95–98. https://doi.org/10.14233/ajchem.2023.26877
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