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Vol. 34 No. 12 (2022): Vol 34 Issue 12, 2022

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Cytotoxic Activity of Ruthenium-Pyridyl Triazole Complexes against Human Cancer Cell

https://doi.org/10.14233/ajchem.2022.23788
Md. Mahbubul Alam
Department of Chemistry, Faculty of Physical Sciences, Shahjalal University of Science and Technology, Sylhet-3114, Bangladesh
Belal Ahmed
Department of Chemistry, Faculty of Physical Sciences, Shahjalal University of Science and Technology, Sylhet-3114, Bangladesh
Md. Shahadat H. Chowdhury
Department of Chemistry, Faculty of Physical Sciences, Shahjalal University of Science and Technology, Sylhet-3114, Bangladesh

Corresponding Author(s) : Md. Mahbubul Alam

mahbubana-che@sust.edu

Asian Journal of Chemistry, Vol. 34 No. 12 (2022): Vol 34 Issue 12, 2022

Abstract

[RuCl (η6-p-cymene)(ligand 1)] (complex 1) was synthesized by simple mixing of 2-(1-((pyridine-2-yl)methyl)-1H-1,2,3-triazol-4-yl)ethyl sodium sulfate (ligand 1) with [RuCl2(η6-p-cymene)]2 in methanol. The microcrystals of the reported complex were characterized by FT-IR, 1H NMR, 13C NMR spectroscopic techniques and elemental analysis. The cytotoxic activity of the ruthenium complex wass tested against human cancer cells A375, A431, BxPC3, A549, HCT-15, LoVo cancer cell and human nontumor cell (human embryonic kidney HEK2) by the MTT assay method. The synthesized ruthenium complex exhibits a limited cytotoxic effect on human cancer cells and also reveals a dose-depended antimetastatic property against LoVo cancer cell.

Keywords

Ruthenium Triazole ligand Cytotoxicity Antimetastatis MTT assay
Mahbubul Alam, M., Ahmed, B., & Shahadat H. Chowdhury, M. (2022). Cytotoxic Activity of Ruthenium-Pyridyl Triazole Complexes against Human Cancer Cell. Asian Journal of Chemistry, 34(12), 3369–3373. https://doi.org/10.14233/ajchem.2022.23788
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