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Synthesis, Characterization and Antimicrobial Activities of Organosilicon(IV) Complexes
Asian Journal of Chemistry,
Vol. 30 No. 8 (2018): Vol 30 Issue 8
Abstract
The new organosilicon(IV) complexes of vanillin and thiophene-2-carboxylic acid hydrazide were synthesized and characterized by elemental analyses, molar conductance, infrared and NMR (1H, 13C and 29Si) spectral analyses. The synthesized compounds were screened for antimicrobial activity against Gram-positive bacteria viz. K. pneumoniae and S. aureus, Gram-negative bacteria viz. E. coli and E. aerogenes, fungi viz. A. niger and C. albicans. The study revealed that some of compounds were found to be more active than the standard drugs used in the assay and further increase in antimicrobial activity was observed on coordination with silicon atoms as compared to their respective free ligands.
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- R.V. Singh and P. Nagpal, Bioinorg. Chem. Appl., 3, 255 (2005); https://doi.org/10.1155/BCA.2005.255.
- S. Belwal, N. Fahmi and R.V. Singh, Appl. Organomet. Chem., 22, 615 (2008); https://doi.org/10.1002/aoc.1426.
- K. Singh, Dharampal and V. Parkash, Phosphorus Sulfur Silicon Rel. Elem., 183, 2784 (2008); https://doi.org/10.1080/10426500802013577.
- R.V. Singh, S.C. Joshi, A. Gajraj and P. Nagpal, Appl. Organomet. Chem., 16, 713 (2002); https://doi.org/10.1002/aoc.378.
- M. Jain, S. Maanju and R.V. Singh, Appl. Organomet. Chem., 18, 471 (2004); https://doi.org/10.1002/aoc.711.
- G.L. Parrilha, R.P. Vieira, A.P. Rebolledo, I.C. Mendes, L.M. Lima, E.J. Barreiro, O.E. Piro, E.E. Castellano and H. Beraldo, Polyhedron, 30, 1891 (2011); https://doi.org/10.1016/j.poly.2011.04.024.
- T.M. Aminabhavi, N.S. Biradar, S.B. Patil, D.E. Hoffman and V.N. Biradar, Inorg. Chim. Acta, 135, 139 (1987); https://doi.org/10.1016/S0020-1693(00)83278-8.
- G.-P. Yu, W.-Z. Bi, G.-D. Si, Y.-X. Yang, H.A. Aisa and L.-Z. Xu, Struct. Chem., 20, 569 (2009); https://doi.org/10.1007/s11224-008-9404-x.
- S.S. Panda and S.C. Jain, Med. Chem. Res., 23, 848 (2014); https://doi.org/10.1007/s00044-013-0686-1.
- V.M. Buha, D.N. Rana, M.T. Chhabria, K.H. Chikhalia, B.M. Mahajan, P.S. Brahmkshatriya and N.K. Shah, Med. Chem. Res., 22, 4096 (2013); https://doi.org/10.1007/s00044-012-0408-0.
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- J. Devi, S. Devi and A. Kumar, MedChemComm, 7, 932 (2016); https://doi.org/10.1039/C5MD00554J.
- M.R. Maurya, S. Agarwal, C. Bader and D. Rehder, Eur. J. Inorg. Chem., 147 (2005); https://doi.org/10.1002/ejic.200400211.
- L. Dawara and R.V. Singh, Appl. Organomet. Chem., 25, 643 (2011); https://doi.org/10.1002/aoc.1813.
- L. Shi, H.M. Ge, S.H. Tan, H.Q. Li, Y.C. Song, H.L. Zhu and R.X. Tan, Eur. J. Med. Chem., 42, 558 (2007); https://doi.org/10.1016/j.ejmech.2006.11.010.
- J. Devi, S. Devi and A. Kumar, Monatsh. Chem., 147, 2195 (2016); https://doi.org/10.1007/s00706-016-1720-z.
- J. Devi, S. Devi and A. Kumar, Heteroatom Chem., 27, 361 (2016); https://doi.org/10.1002/hc.21347.
References
R.V. Singh and P. Nagpal, Bioinorg. Chem. Appl., 3, 255 (2005); https://doi.org/10.1155/BCA.2005.255.
S. Belwal, N. Fahmi and R.V. Singh, Appl. Organomet. Chem., 22, 615 (2008); https://doi.org/10.1002/aoc.1426.
K. Singh, Dharampal and V. Parkash, Phosphorus Sulfur Silicon Rel. Elem., 183, 2784 (2008); https://doi.org/10.1080/10426500802013577.
R.V. Singh, S.C. Joshi, A. Gajraj and P. Nagpal, Appl. Organomet. Chem., 16, 713 (2002); https://doi.org/10.1002/aoc.378.
M. Jain, S. Maanju and R.V. Singh, Appl. Organomet. Chem., 18, 471 (2004); https://doi.org/10.1002/aoc.711.
G.L. Parrilha, R.P. Vieira, A.P. Rebolledo, I.C. Mendes, L.M. Lima, E.J. Barreiro, O.E. Piro, E.E. Castellano and H. Beraldo, Polyhedron, 30, 1891 (2011); https://doi.org/10.1016/j.poly.2011.04.024.
T.M. Aminabhavi, N.S. Biradar, S.B. Patil, D.E. Hoffman and V.N. Biradar, Inorg. Chim. Acta, 135, 139 (1987); https://doi.org/10.1016/S0020-1693(00)83278-8.
G.-P. Yu, W.-Z. Bi, G.-D. Si, Y.-X. Yang, H.A. Aisa and L.-Z. Xu, Struct. Chem., 20, 569 (2009); https://doi.org/10.1007/s11224-008-9404-x.
S.S. Panda and S.C. Jain, Med. Chem. Res., 23, 848 (2014); https://doi.org/10.1007/s00044-013-0686-1.
V.M. Buha, D.N. Rana, M.T. Chhabria, K.H. Chikhalia, B.M. Mahajan, P.S. Brahmkshatriya and N.K. Shah, Med. Chem. Res., 22, 4096 (2013); https://doi.org/10.1007/s00044-012-0408-0.
V. Judge, B. Narasimhan, M. Ahuja, D. Sriram, P. Yogeeswari, E. De Clercq, C. Pannecouque and J. Balzarini, J. Med. Chem. Res., 21, 1451 (2012); https://doi.org/10.1007/s00044-011-9662-9.
J. Devi, S. Devi and A. Kumar, MedChemComm, 7, 932 (2016); https://doi.org/10.1039/C5MD00554J.
M.R. Maurya, S. Agarwal, C. Bader and D. Rehder, Eur. J. Inorg. Chem., 147 (2005); https://doi.org/10.1002/ejic.200400211.
L. Dawara and R.V. Singh, Appl. Organomet. Chem., 25, 643 (2011); https://doi.org/10.1002/aoc.1813.
L. Shi, H.M. Ge, S.H. Tan, H.Q. Li, Y.C. Song, H.L. Zhu and R.X. Tan, Eur. J. Med. Chem., 42, 558 (2007); https://doi.org/10.1016/j.ejmech.2006.11.010.
J. Devi, S. Devi and A. Kumar, Monatsh. Chem., 147, 2195 (2016); https://doi.org/10.1007/s00706-016-1720-z.
J. Devi, S. Devi and A. Kumar, Heteroatom Chem., 27, 361 (2016); https://doi.org/10.1002/hc.21347.