Issue

Vol. 34 No. 11 (2022): Vol 34 Issue 11, 2022

Copyright (c) 2022 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Phytochemistry, Ethnobotany and Pharmacological Uses of Tinospora cordifolia with Special Reference to SARS-COV-2: A Review

https://doi.org/10.14233/ajchem.2022.23970
Shahnaz Alom
Girijananda Chowdhury Institute of Pharmaceutical Science-Tezpur, Dekargaon, Sonitpur-784501, India
Dolly Kalita
Girijananda Chowdhury Institute of Pharmaceutical Science-Tezpur, Dekargaon, Sonitpur-784501, India
Jesminara Ahmed
Girijananda Chowdhury Institute of Pharmaceutical Science-Tezpur, Dekargaon, Sonitpur-784501, India
Kaifur Rahman
Girijananda Chowdhury Institute of Pharmaceutical Science-Tezpur, Dekargaon, Sonitpur-784501, India
Manyajyoti Boruah
Girijananda Chowdhury Institute of Pharmaceutical Science-Tezpur, Dekargaon, Sonitpur-784501, India
Murchana Sarmah
Girijananda Chowdhury Institute of Pharmaceutical Science-Tezpur, Dekargaon, Sonitpur-784501, India
Nikusmita Das
Girijananda Chowdhury Institute of Pharmaceutical Science-Tezpur, Dekargaon, Sonitpur-784501, India
Farak Ali
Girijananda Chowdhury Institute of Pharmaceutical Science-Tezpur, Dekargaon, Sonitpur-784501, India

Corresponding Author(s) : Farak Ali

alifarak347@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 11 (2022): Vol 34 Issue 11, 2022

Abstract

Medicinal plants or medicinal herbs possess therapeutic properties or exert beneficial pharmacological effects on human. From time immemorial, people have been using various medicinal plants without even knowing their phytochemistry and pharmacological properties as a medicine for treating numerous ailments. As technology developed and upgraded, people used to screen out various phytoconstituents as well as evaluate their basic pharmacological properties. Tinospora cordifolia is a medicinal herb which is commonly known as Giloy belong to family menispermaceae. It can also be found in places like Africa, China, South-East Asia, Indo-Malaya region and Australia. Traditionally, people use this herb as prominent food materials due to their higher nutraceutical value and various healing properties. For phytochemical investigation, extraction of whole plant is preferable whereas most of the phytochemical are found to be present in leaves. Various potent phytochemicals are found in this herb such as tinosponone, tinocordiside, tinosporaside, cordifoliside, β-sitosterol, mekisterone A, etc. which are belong to class of alkaloids, sesquiterpenoids, glycosides, steroids, volatile oil, etc. Owing to the presence of these potent compounds, it exhibits wide range of large number of pharmacological activities such as antiviral, antibacterial, antifungal, antioxidant, antidiabetic, anticancer activities, etc. In past two years, SARS-CoV-2 infections has taken life of millions of people across the globe and there were no any vaccine or proper antiviral medicine available to defend this deadly pandemic, hence people were mostly relying on herbal plant therapy. Giloy is one such magical herb which exhibit healing properties in SARS-CoV-2 infected patients. Moreover, in-silico studies have been carried out to determine the binding affinity as well as inhibiting potential of various phytoconstituents of giloy. In this review work, we compiled all the updated information about T. cordifolia as well as emphasizing more on SARS-CoV-2 inhibiting potential.

Keywords

Tinospora cordifolia Giloy Phytochemistry Ethnomedicine Pharmacology SARS-CoV-2 inhibition
Alom, S., Kalita, D., Ahmed, J., Rahman, K., Boruah, M., Sarmah, M., … Ali, F. (2022). Phytochemistry, Ethnobotany and Pharmacological Uses of Tinospora cordifolia with Special Reference to SARS-COV-2: A Review. Asian Journal of Chemistry, 34(11), 2786–2796. https://doi.org/10.14233/ajchem.2022.23970
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. A.K. Meena, A. Singh, P. Panda, S. Mishra and M.M. Rao, Int. J Pharmacogn. Phytochem. Res., 2, 50 (2010).
  2. K. Rajandeep, K. Suman and S.K. Anil, Int. J. Pharm. Innov., 2, 13 (2012).
  3. S. Ghosh and S. Saha, Anc. Sci. Life, 31, 151 (2012); https://doi.org/10.4103/0257-7941.107344
  4. A. Upadhyay, K. Kumar, A. Kumar and H. Mishra, Int. J. Ayurveda Res., 1, 112 (2010); https://doi.org/10.4103/0974-7788.64405
  5. C. Namrata, Int. J. Pharm. Sci. Res., 53, 891 (2013).
  6. Anonymous, The Ayurvedic Pharmacopoeia of India Part-I, Department of Ayush, Government of India Ministry of Health and Family Welfare, vol. I (2000).
  7. H.C. Goel, J. Prasad, S. Singh, R.K. Sagar, P.K. Agrawala, M. Bala, A.K. Sinha and R. Dogra, J. Radiat. Res., 45, 61 (2004); https://doi.org/10.1269/jrr.45.61
  8. V.V. Sonkamble and L.H. Kamble, Am. J. Phytomedicine Clin. Ther., 3, 2015 (2015).
  9. K. Sinha, N.P. Mishra, J. Singh and S.P.S. Khanuja, Indian J. Tradit. Knowl., 3, 25770 (2004).
  10. M.M. Khan, M.S. Haque and M.S.I. Chowdhury, Asian J. Med. Biol. Res., 2, 508 (2017); https://doi.org/10.3329/ajmbr.v2i4.30989
  11. C. Bharathi, A.H. Reddy, G. Nageswari, B.S. Lakshmi, M. Soumya, D.S. Vanisri and B. Venkatappa, Int. J. Scient. Res. Rev., 7, 585 (2018).
  12. K.R. Kirtikar, B.D. Basu and I.C.S. An, Indian Medicinal Plants, Lalit Mohan Basu: Allahabad, India, pp. 1655-1656 (1935).
  13. S. Nasreen, R. Radha, N. Jayashree, B. Selvaraj and A. Rajendran, Int. J. Compr. Pharm., 5, 1 (2010).
  14. S.S. Singh, S.C. Pandey, S. Srivastava, V.S. Gupta and B. Patro, Indian J. Pharmacol., 35, 83 (2003).
  15. Spandana U, Ali SL, Nirmala T, Santhi M, Sipai Babu SD., Int. J. Curr. Pharm. Rev. Res., 4, 61 (2013).
  16. A. Patel, P. Bigoniya, C.S. Singh and N.S. Patel, Indian J. Pharmacol., 45, 427 (2013); https://doi.org/10.4103/0253-7613.117717
  17. H. Ali and S. Dixit, Sci. World J., 2013, 376216 (2013); https://doi.org/10.1155/2013/376216
  18. T.J. Hsieh, Y.C. Chia, Y.C. Wu and C.Y. Chen, J. Chin. Chem. Soc., 51, 443 (2004); https://doi.org/10.1002/jccs.200400068
  19. S. Krupanidhi, K.P. Abraham, T.C. Venkateswarulu, V.S. Ayyagari, B.M. Nazneen B.D. John, N.A. Venkata and G. Aishwarya, J. Biomol. Struct. Dyn., 39, 5799 (2021); https://doi.org/10.1080/07391102.2020.1787226
  20. G. Joshi and R. Kaur, Int. J. Pharm. Sci. Res., 7, 890 (2016); https://doi.org/10.13040/IJPSR.0975-8232.7(3).890-97
  21. M.B. Patel and S. Mishra, Phytother. Res., 26, 1342 (2012); https://doi.org/10.1002/ptr.3721
  22. M.A. Khan, A.I. Gray and P.G. Waterman, Phytochemistry, 28, 273 (1989); https://doi.org/10.1016/0031-9422(89)85057-5
  23. K. Swaminathan, U.C. Sinha, R.K. Bhatt, B.K. Sabata and S.S. Tavale, Acta Crystallogr. C, 45, 134 (1989); https://doi.org/10.1107/S0108270188009953
  24. S. Ghosal and R.A. Vishwakarma, J. Nat. Prod., 60, 839 (1997); https://doi.org/10.1021/np970169z
  25. P. Tiwari, P. Nayak, S.K. Prusty and P.K. Sahu, Syst. Rev. Pharm., 9, 70 (2018); https://doi.org/10.5530/srp.2018.1.14
  26. P. Sharma, B.P. Dwivedee, D. Bisht, A.K. Dash and D. Kumar, Heliyon, 5, e02437 (2019); https://doi.org/10.1016/j.heliyon.2019.e02437
  27. A. Akhila, K. Rani and R.S. Thakur, Phytochemistry, 30, 2573 (1991); https://doi.org/10.1016/0031-9422(91)85103-7
  28. J. Lv, D. Xu, V. Perkovic, X. Ma, D.W. Johnson, M. Woodward, A. Levin, H. Zhang and H. Wang, J. Am. Soc. Nephrol., 23, 1108 (2012); https://doi.org/10.1681/ASN.2011111112
  29. E. Mckeown, V.P. Bykerk, F. De Leon, A. Bonner, C. Thorne, C.A. Hitchon, G. Boire, B. Haraoui, D.S. Ferland, E.C. Keystone and J.E. Pope, Rheumatology, 51, 1662 (2012); https://doi.org/10.1093/rheumatology/kes079
  30. S. Sundarraj, R. Thangam, V. Sreevani, K. Kaveri, P. Gunasekaran, S. Achiraman and S. Kannan, J. Ethnopharmacol., 141, 803 (2012); https://doi.org/10.1016/j.jep.2012.03.014
  31. P. Sharma, B.P. Dwivedee, D. Bisht, A.K. Dash and D. Kumar, Heliyon, 5, e02437 (2019); https://doi.org/10.1016/j.heliyon.2019.e02437
  32. A.K. Upadhyay, K. Kumar, A. Kumar and H.S. Mishra, Int. J. Ayurveda Res., 1, 112 (2010); https://doi.org/10.4103/0974-7788.64405
  33. S. Saha and S. Ghosh, Anc. Sci. Life, 31, 151 (2012); https://doi.org/104103/0257-7941.107344
  34. C. Namrata, M.B. Siddiqui, A. Shazia and K. Sayyada, Int. J. Pharm. Sci. Res., 53, 891 (2013); https://doi.org/10.13040/IJPSR.0975-8232.4(3).891-99
  35. V. Gupta, N. Srivastava, A.B. Pant, V.K. Singh, V. Gupta, S. Kumar and T. Jafar, Toxicol. Int., 18, 168 (2011); https://doi.org/10.4103/0971-6580.84272
  36. V. Sharma and D. Pandey, Toxicol. Int., 17, 8 (2010); https://doi.org/10.4103/0971-6580.68341
  37. T.P. Hamsa and G. Kuttan, Exp. Toxicol. Pathol., 64, 307 (2012); https://doi.org/10.1016/j.etp.2010.09.003
  38. J. Paval, S.K. Kaitheri, B.K. Potu, S. Govindan, R.S. Kumar, S.N. Narayanan and S. Moorkoth, Clinics, 64, 357 (2009); https://doi.org/10.1590/S1807-59322009000400015
  39. P.S.M. Prince and V.P. Menon, Phytother. Res., 15, 213 (2001); https://doi.org/10.1002/ptr.707
  40. T. Nandkumar, T. Dinkar, M. Popat and D. Mohan, World J. Pharm. Res., 10, 990 (2021).
  41. R. Mishra, S. Manchanda, M. Gupta, T. Kaur, V. Saini, A. Sharma and G. Kaur, Sci. Rep., 6, 25564 (2016); https://doi.org/10.1038/srep25564
  42. V.K. Pendese, A.P. Dadhich, P.N. Mathur, M.S. Bal and B.R. Madam, Indian J. Pharmacol., 9, 221 (1977).
  43. K.L. Bairy, Y. Rao and K.L. Kumar, Indian J. Pharmcol. Ther., 3, 57 (2004).
  44. A. Agarwal, S. Malini, K.L. Bairy and M.S. Rao, Indian J. Pharmacol., 34, 339 (2002).
  45. P.S.M. Prince and V.P. Menon, Phytother. Res., 17, 410 (2003); https://doi.org/10.1002/ptr.1130
  46. V. Sivakumar and M.S. Dhana Rajan, Indian J. Pharm. Sci., 72, 795 (2010); https://doi.org/10.4103/0250-474X.84600
  47. R.N. Gacche and N.A. Dhole, Food Chem. Toxicol., 49, 1806 (2011); https://doi.org/10.1016/j.fct.2011.04.032
  48. A. Rawal, M. Muddeshwar and S. Biswas, Biochem. Biophys. Res. Commun., 324, 588 (2004); https://doi.org/10.1016/j.bbrc.2004.09.094
  49. N. Upadhyay, S.A. Ganie, R.K. Agnihotri and R. Sharma, J. Pharmacogn. Phytochem., 3, 63 (2014).
  50. M. Subramanian, G.J. Chintalwar and S. Chattopadhyay, Redox Rep., 7, 137 (2002); https://doi.org/10.1179/135100002125000370
  51. B.T. Kavitha, S.D. Shruthi, S.P. Rai and Y.L. Ramachandra, J. Basic Clin. Pharm., 2, 139 (2011).
  52. V. Janghel, P. Patel and S.S. Chandel, Ann. Hepatol., 18, 658 (2019); https://doi.org/10.1016/j.aohep.2019.05.003
  53. M.H. Stanca, A. Nagy, M. Tosa and L. Vlad, Chirurgia, 106, 205 (2011).
  54. U. Sharma, M. Bala, N. Kumar, B. Singh, R.K. Munshi and S. Bhalerao, J. Ethnopharmacol., 141, 918 (2012); https://doi.org/10.1016/j.jep.2012.03.027
  55. P. More and K. Pai, Immunopharmacol. Immunotoxicol., 34, 368 (2012); https://doi.org/10.3109/08923973.2011.606324
  56. A.K. Verma and V.K. Anita, Res. J. Chem. Sci., 1, 71 (2011).
  57. M. Jahfar and P. Azadi, Acta Pharm., 54, 73 (2004).
  58. V. Aher and A. Wahi, Int. J. Curr. Pharm. Res., 2, 50 (2010).
  59. R. Raghu, D. Sharma, R. Ramakrishnan, S. Khanam, G.J. Chintalwar and K.B. Sainis, Immunol. Lett., 123, 60 (2009); https://doi.org/10.1016/j.imlet.2009.02.005
  60. G.C. Jagetia, V. Nayak and M.S. Vidyasagar, Cancer Lett., 127, 71 (1998); https://doi.org/10.1016/S0304-3835(98)00047-0
  61. R.P. Singh, S. Banerjee, P.V.S. Kumar, K.A. Raveesha and A.R. Rao, Phytomedicine, 13, 74 (2006); https://doi.org/10.1016/j.phymed.2004.02.013
  62. M. Bala, K. Pratap, P.K. Verma, B. Singh and Y. Padwad, J. Ethnopharmacol., 175, 131 (2015); https://doi.org/10.1016/j.jep.2015.08.001
  63. K. Singh, M. Panghal, S. Kadyan, U. Chaudhary and J.P. Yadav, J. Nanomed. Nanotechnol., 5, 40 (2014); https://doi.org/10.1186/s12951-014-0040-x
  64. V. Shanthi, R. Nelson, M. Nefhi and N.E. Africa, Int. J. Curr. Microbiol. App. Sci., 2, 190 (2013).
  65. V. Duraipandiyan, M. Ayyanar and S. Ignacimuthu, BMC Complement. Altern. Med., 6, 35 (2006); https://doi.org/10.1186/1472-6882-6-35
  66. A.S. Narayanan, S.S.S. Raja, K. Ponmurugan, K. Natarajaseenivasan, S.C. Kandekar, A. Maripandi and Q. Mandeel, Benef. Microbes, 2, 235 (2011); https://doi.org/10.3920/BM2010.0033
  67. B. Goel, N. Pathak, D.K. Nim, S.K. Singh, R.K. Dixit and R. Chaurasia, J. Clin. Diagn. Res., 8, HC01-4 (2014); https://doi.org/10.7860/JCDR/2014/9207.4671
  68. I.D.G. Duarte, M. Nakamura and S.H. Ferreira, Braz. J. Med. Biol. Res., 21, 341 (1988).
  69. B. Ashok, B. Ravishankar, P. Prajapati and S. Bhat, Ayu, 31, 367 (2010); https://doi.org/10.4103/0974-8520.77162
  70. M.K. Sangeetha, C.D. Priya and H.R. Vasanthi, Phytomedicine, 20, 246 (2013); https://doi.org/10.1016/j.phymed.2012.11.006
  71. A.D. Chougale, V.A. Ghadyale, S.N. Panaskar and A.U. Arvindekar, J. Enzym. Inhib. Med. Chem., 24, 998 (2009); https://doi.org/10.1080/14756360802565346
  72. S.P.S.S. Zinjarde, S.Y. Bhargava and A.R. Kumar, BMC Complement. Altern. Med., 11, 5 (2011); https://doi.org/10.1186/1472-6882-11-5
  73. P. Stanely, M. Prince and V.P. Menon, J. Ethnopharmacol., 70, 9 (2000); https://doi.org/10.1016/S0378-8741(99)00136-1
  74. D. Singh and P.K. Chaudhuri, Nat. Prod. Commun., 12, 299 (2017).
  75. B. Patgiri, B. Umretia, P. Vaishnav, P. Prajapati, V. Shukla and B. Ravishankar, Ayu, 35, 108 (2014); https://doi.org/10.4103/0974-8520.141958
  76. V. Singh and H.S. Banyal, Curr. Sci., 101, 1356 (2011).
  77. S.S. Nayampalli, S.S. Ainapure, B.D. Samant, R.G. Kudtarkar, N.K. Desai and K.C. Gupta, J. Postgrad. Med., 34, 233 (1988).
  78. K.N. Puranik, K.F. Kammar and S. Devi, Biomed. Res., 18, 179 (2007).
  79. H.C. Goel, I. Prem Kumar and S.V.S. Rana, Indian J. Exp. Biol., 40, 727 (2002).
  80. P.A. Bafna and R. Balaraman, Phytomedicine, 12, 264 (2005); https://doi.org/10.1016/j.phymed.2003.12.009
  81. M. Tiwari, U.N. Dwivedi and P. Kakkar, J. Ethnopharmacol., 153, 326 (2014); https://doi.org/10.1016/j.jep.2014.01.031
  82. D.N.K. Sarma, R.L. Khosa, J.P.N. Chansauria and M. Sahai, Phytother. Res., 9, 589 (1995); https://doi.org/10.1002/ptr.2650090811
  83. D. Aronson and E.R. Edelman, Cardiol Clin., 32, 439 (2014); https://doi.org/10.1016/j.ccl.2014.04.001
  84. T. Shanbhag, S. Shenoy and M.C. Rao, Indian Drugs, 42, 217 (2005).
  85. G. Abiramasundari, K.R. Sumalatha and M. Sreepriya, J. Ethnopharmacol., 141, 474 (2012); https://doi.org/10.1016/j.jep.2012.03.015
  86. L. Gao, G. Cai and X. Shi, Biol. Pharm. Bull., 31, 2245 (2008); https://doi.org/10.1248/bpb.31.2245
  87. H. Birla, S.N. Rai, S.S. Singh, W. Zahra, A. Rawat, N. Tiwari, R.K. Singh, A. Pathak and S.P. Singh, Neuromol. Med., 21, 42 (2019); https://doi.org/10.1007/s12017-018-08521-7
  88. D.R. Pachman, J.M. Jones and C.L. Loprinzi, Int. J. Womens Health, 2, 123 (2010).
  89. A. Das, D. Pandita, G.K. Jain, P. Agarwal, A.S. Grewal, R.K. Khar and V. Lather, Chem. Biol. Interact., 341, 109449 (2021); https://doi.org/10.1016/j.cbi.2021.109449
  90. P. Chowdhury, J. Biomol. Struct. Dyn., 39, 6792 (2021); https://doi.org/10.1080/07391102.2020.1803968
  91. V. Bhapkar, T. Sawant and S. Bhalerao, J. Ayurveda Integr. Med., 13, 100370 (2022); https://doi.org/10.1016/j.jaim.2020.10.012
  92. S. Alsuhaibani and M.A. Khan, J. Immunol. Res., 2017, 1 (2017); https://doi.org/10.1155/2017/1787803
  93. K. Dhama, S. Sachan, R. Khandia, A. Munjal, H.M.N. Iqbal, S.K. Latheef, K. Karthik, H.A. Samad, R. Tiwari and M. Dadar, Recent Pat. Endocr. Metab. Immune Drug Discov., 10, 96 (2017); https://doi.org/10.2174/1872214811666170301105101
  94. D. Mani, A. Kaushik, A. Husain, H. Awasthi, D.P. Singh and R. Khan, Pharmacogn. Mag., 13, S658 (2017); https://doi.org/10.4103/pm.pm_448_16
  95. V.R. Thawani, U.K. Varadpande, S.D. Sontakke, R.P. Singh, R.K. Khiyani and M.V. Kalikar, Indian J. Pharmacol., 40, 107 (2008); https://doi.org/10.4103/0253-7613.42302
  96. P. Shree, P. Mishra, C. Selvaraj, S.K. Singh, R. Chaube, N. Garg and Y.B. Tripathi, J. Biomol. Struct. Dyn., 40, 190 (2022); https://doi.org/10.1080/07391102.2020.1810778
  97. G. Abiramasundari, C.M. Mohan Gowda and M. Sreepriya, J. Ayurveda Integr. Med., 9, 161 (2018); https://doi.org/10.1016/j.jaim.2017.04.003
  98. R. Lafont, M. Serova, B. Didry-Barca, S. Raynal, L. Guibout, L. Dinan, S. Veillet, M. Latil, W. Dioh and P.J. Dilda, J. Mol. Endocrinol., 68, 77 (2022); https://doi.org/10.1530/JME-21-0033
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 1 Download : 0