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Vol. 34 No. 10 (2022): Vol 34 Issue 10, 2022

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ADME Analysis of Crude Extracts of Exacum bicolor Roxb. and in vitro Screening for Antioxidant, Antimicrobial and Cytotoxicity Assays

https://doi.org/10.14233/ajchem.2022.23847
S.S. Achar
Department of Biotechnology, BMS College of Engineering, P.O. Box no. 1908, Basavanagudi, Bengaluru-560001, India
L. Pethakamsetty
Department of Microbiology, Andhra University College of Science and Technology, Andhra University, Visakhapatnam-530003, India
A.A. Pathan
Department of Biotechnology, GIT, GITAM University, Visakhapatnam-530045, India
N.R. Parine
Department of Biochemistry, Genome Research Chair, College of Science, King Saud University, Riyadh, Kindgom of Saudi Arabia
S. Vinjamuri
Department of Biotechnology, BMS College of Engineering, P.O. Box no. 1908, Basavanagudi, Bengaluru-560001, India

Corresponding Author(s) : S. Vinjamuri

saishav.bt@bmsce.ac.in

Asian Journal of Chemistry, Vol. 34 No. 10 (2022): Vol 34 Issue 10, 2022

Abstract

With the increase in medical pandemics caused by emerging and re-emerging microbial pathogens, topping multi drug resistance, there is always a dire requirement for the novel drugs to treat diseases. In view of the imperative need for lead molecules addressing ailments, the authors have extended their phytochemical studies on the crude extracts of Exacum bicolor Roxb, to in silico ADME analysis followed by in vitro screening for biological activities. In present study, the crude extracts of E. bicolor are subjected to GC-MS analysis and a total of 32 phytoconstituents were identified and considered for ADME analysis by Swiss ADME software. This study represents the first-time reports on the in silico screening of the plant extracts of Exacum bicolor. Further preliminary screening of the crude extracts displayed moderate antioxidant, cytotoxic, antibacterial and antifungal properties, which might be due to the presence of phenolic and alkaloid derivatives.

Keywords

Exacum bicolor Roxb. Antimicrobial ADME Antioxidant activity Cytotoxicity
Achar, S., Pethakamsetty, L., Pathan, A., Parine, N., & Vinjamuri, S. (2022). ADME Analysis of Crude Extracts of Exacum bicolor Roxb. and in vitro Screening for Antioxidant, Antimicrobial and Cytotoxicity Assays. Asian Journal of Chemistry, 34(10), 2633–2638. https://doi.org/10.14233/ajchem.2022.23847
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References
  1. G. Bocci, E. Carosati, P. Vayer, A. Arrault, S. Lozano and G. Cruciani, Sci. Rep., 7, 6359 (2017); https://doi.org/10.1038/s41598-017-06692-0
  2. S. Ekins, J. Mestres and B. Testa, Br. J. Pharmacol., 152, 9 (2007); https://doi.org/10.1038/sj.bjp.0707305
  3. N.A. Durán-Iturbide, B.I. Díaz-Eufracio and J.L. Medina-Franco, ACS Omega, 5, 16076 (2020); https://doi.org/10.1021/acsomega.0c01581
  4. J. Caldwell, I. Gardner and N. Swales, Toxicol. Pathol., 23, 102 (1995); https://doi.org/10.1177/019262339502300202
  5. T. Takebe, R. Imai and S. Ono, Clin. Transl. Sci., 11, 597 (2018); https://doi.org/10.1111/cts.12577
  6. M.T. Mahanthesh, D. Ranjith, Y. Raghavendra, R. Jyothi, G. Narappa and M.V. Ravi, J. Pharmcol. Phytochem., 9, 1799 (2020).
  7. F. Mirzaee, A. Hosseini, H.B. Jouybari, A. Davoodi and M. Azadbakht, J. Tradit. Complement. Med., 7, 400 (2017); https://doi.org/10.1016/j.jtcme.2016.12.013
  8. A. Singh, Int. J. Pharm. Sci. Nanotechnol., 1, 33 (2008); https://doi.org/10.37285/10.37285/ijpsn.2008.1.1.4
  9. C. Veeresham, J. Adv. Pharm. Technol. Res., 3, 200 (2012); https://doi.org/10.4103/2231-4040.104709
  10. D.S.M.J. Basha, D.G.N.M. Rao, D.R. Ramachandra and D.P.I. Prasad, Int. J. Adv. Res. (Indore), 4, 1656 (2016); https://doi.org/10.21474/IJAR01/489
  11. S.B. Gaikwad, G.K. Mohan and M.S. Rani, Pharm. Crop., 5, 11 (2014); https://doi.org/10.2174/2210290601405010011
  12. R.C. Gupta, D. Chang, S. Nammi, A. Bensoussan, K. Bilinski and B.D. Roufogalis, Diabetol. Metab. Syndr., 9, 59 (2017); https://doi.org/10.1186/s13098-017-0254-9
  13. A.G. Atanasov, S.B. Zotchev, V.M. Dirsch, the International Natural Product Sciences Taskforce and C.T. Supuran, Nat. Rev. Drug Discov., 20, 200 (2021); https://doi.org/10.1038/s41573-020-00114-z
  14. A.M. Ashwini, H. Ramakrishnaiah, S.H. Manohar and M. Majumdar, In Vitro Cell. Dev. Biol. Plant, 51, 659 (2015); https://doi.org/10.1007/s11627-015-9726-5
  15. U. Sreelatha, T.S. Baburaj, C.N. Kutty, P.A. Nazeem and J. Bhaskar, Indian J. Nat. Prod. Resour., 6, 402 (2007).
  16. K. Rajisha and J. Fernanades, Res. J. Pharm. Technol., 13, 1752 (2020); https://doi.org/10.5958/0974-360X.2020.00316.9
  17. K.S. Vinayaka, H.S. Ashwini, T.R.P. Kekuda and Y.L. Krishanamurthy, Asian Pac. J. Health Sci., 3, 161 (2016); https://doi.org/10.21276/apjhs.2016.3.1.26
  18. Y. Vaghasiya, R. Dave and S. Chanda, Res. J. Med. Plants, 5, 567 (2011).
  19. K. Das, R. Dang, G. Sivaraman and R.P. Ellath, Turk. J. Pharm. Sci., 15, 156 (2018); https://doi.org/10.4274/tjps.54376
  20. A.M. Appaji, L. Puttarudrappa, B.V. Ravi and M. Majumdar, Bangladesh J. Pharmacol., 10, 45 (2015).
  21. S. Vinjamuri and S. Sharad, World J. Pharm. Pharm. Sci., 6, 2134 (2017); https://doi.org/10.20959/wjpps20177-9655
  22. J.B. Harborne, Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis, Chapman and Hall, London, pp. 1-36 (1984).
  23. C.K. Kokate, Practical Pharmacognosy, Vallabh Prakashan: Delhi, pp. 21-45 (2014).
  24. J.K. Holopainen, M. Kivimäenpää and R. Julkunen-Tiitto, Trends Biotechnol., 36, 7 (2018); https://doi.org/10.1016/j.tibtech.2017.08.009
  25. D.M. Coen and P.A. Schaffer, Nat. Rev. Drug Discov., 2, 278 (2003); https://doi.org/10.1038/nrd1065
  26. S. Fatima, P. Gupta, S. Sharma, A. Sharma and S.M. Agarwal, Future Med. Chem., 12, 69 (2019); https://doi.org/10.4155/fmc-2019-0206
  27. M.J. Waring, Bioorg. Med. Chem. Lett., 19, 2844 (2009); https://doi.org/10.1016/j.bmcl.2009.03.109
  28. Y.C. Martin, J. Med. Chem., 48, 3164 (2005); https://doi.org/10.1021/jm0492002
  29. A. Daina, O. Michielin and V. Zoete, Sci. Rep., 7, 42717 (2017); https://doi.org/10.1038/srep42717
  30. F. Kavanagh, Analytical Microbiology-II, Academic Press: New York, pp. 241-243 (1992).
  31. L. Pethakamsetty, K. Kothapenta, H.R. Nammi, L.K. Ruddaraju, P. Kollu, S.G. Yoon and S.V.N. Pammi, J. Environ. Sci., 55, 157 (2017); https://doi.org/10.1016/j.jes.2016.04.027
  32. W. Brand-Williams, M.E. Cuvelier and C. Berset, Lebensm. Wiss. Technol., 28, 25 (1995); https://doi.org/10.1016/S0023-6438(95)80008-5
  33. N. Janakiraman and M. Johnson, J. Acupunct. Meridian Stud., 9, 151 (2016); https://doi.org/10.1016/j.jams.2016.04.004
  34. L. Huttada and M.B. Hiremath, Int. J. Recent Sci. Res., 7, 10772 (2016).
  35. K. Rajisha and J. Fernanades, Res. J. Pharm. Tech., 13, 1752 (2020);https://doi.org/10.5958/0974-360X.2020.00316.9
  36. S.S. Achar and S. Vinjamuri, Asian J. Pharm. Clin. Res., 14, 36 (2021); https://doi.org/10.22159/ajpcr.2021.v14i5.40966
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