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Vol. 30 No. 8 (2018): Vol 30 Issue 8

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Marine Sponge Derived Cyclic Peptides for Removal of Mercury

https://doi.org/10.14233/ajchem.2018.21356
Sweta Sharma
Department of Chemistry, University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur-208 024, India *Corresponding author: E-mail: arpitayadav@yahoo.co.in
Arpita Yadav*
Department of Chemistry, University Institute of Engineering and Technology, Chhatrapati Shahu Ji Maharaj University, Kanpur-208 024, India *Corresponding author: E-mail: arpitayadav@yahoo.co.in

Asian Journal of Chemistry, Vol. 30 No. 8 (2018): Vol 30 Issue 8

Abstract

This study deals with heavy metal toxicity removal in particular mercury and methyl mercury ions in human. Mercury toxicity in the form of thimerosal used as preservative in vaccines has been linked to autism in children and constitutes an important research topic. This study deals with possible removal of Hg2+ and CH3Hg+ ions from human utilizing marine sponge derived cyclic peptides and their analogs. Ab initio molecular orbital calculations with complete optimization and intermolecular interaction calculations have been utilized for the purpose. A number of marine sponge derived cyclic peptides have been shown to be suitable for non-covalent carriage of mercury ions without premature expulsion probability. Stylissatin and its analogs with enhanced ‘drug–like features’ have been recommended as lead compounds for the development of non-toxic biocompatible drugs for mercury toxicity removal in human. These findings remain to be verified by in vitro or in vivo pharmacological studies.

Keywords

Marine sponge Cyclic peptide Stylissatin Methyl mercury Druggability.
Sharma, S., & Yadav*, A. (2018). Marine Sponge Derived Cyclic Peptides for Removal of Mercury. Asian Journal of Chemistry, 30(8), 1873–1880. https://doi.org/10.14233/ajchem.2018.21356
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