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Aloe vera Loaded (Polyvinyl Alcohol) Cryogel: Potential Wound Healer
Corresponding Author(s) : Amita Chhatri
Asian Journal of Chemistry,
Vol. 34 No. 10 (2022): Vol 34 Issue 10, 2022
Abstract
The present work describes the preparation methodology of polyvinyl alcohol and Aloe vera hydrogels and their potential role in wound healing. Aloe vera is frequently used in treating many diseases due to its spectacular properties (anti-inflammatory, antiviral, antitumor and antibacterial) which assist in wound healing and help in treating many diseases a range of ailments. The designing of Aloe vera loaded polyvinyl alcohol (PVA) blend hydrogels (coined as cryogels) was done following repeated freeze-thaw cycles method. Characterization of the cryogels was done using some analytical techniques to study its properties and possible applications. The FTIR spectra shows that Aloe vera loaded PVA cryogels are interconnected by hydrogen bonding. Scanning electron microscope analysis established the porous nature of crogels. These hydrogels show water imbibing capacity, which depends on the experimental conditions and the chemical composition of the gel. The factors affecting the swelling ratio of crogels are amount of PVA, Aloe vera, number of Freez-Thaw cycles, pH and medium. The pore size of the cryogels also decreases with increasing number of freeze-thaw cycles. The Aloe vera-PVA cryogel is healing compatible with blood as there is less than 2% hemolysis.
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- R. Pereira, A. Mendes and P. Bártolo, Procedia CIRP, 5, 210 (2013); https://doi.org/10.1016/j.procir.2013.01.042
- J.S. Boateng, K.H. Matthews, H.N.E. Stevens and G.M. Eccleston, J. Pharm. Sci., 97, 2892 (2008); https://doi.org/10.1002/jps.21210
- A. Sood, M.S. Granick and N.L. Tomaselli, Adv. Wound Care, 3, 511 (2014); https://doi.org/10.1089/wound.2012.0401
- X. Yang, K. Yang, S. Wu, X. Chen, F. Yu, J. Li, M. Ma and Z. Zhu, Radiat. Phys. Chem., 79, 606 (2010); https://doi.org/10.1016/j.radphyschem.2009.12.017
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- Y. Pounikar, Int J. Pharm. Sci., 4, 85 (2012).
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- T. Derbe, B. Yilma and S. Badaca, World J. Pharm. Pharm. Sci., 4, 185 (2015).
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- V. Vivcharenko and A. Przekora, Appl. Sci., 11, 4114 (2021); https://doi.org/10.3390/app11094114
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- D.T. Padavan, A.M. Hamilton, L.E. Millon, D.R. Boughner and W. Wan, Acta Biomater., 7, 258 (2011); https://doi.org/10.1016/j.actbio.2010.07.038
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- M. Rodriguez-Bigas, N.I. Cruz and A. Suarez, Plast. Reconstr. Surg., 81, 386 (1988); https://doi.org/10.1097/00006534-198803000-00012
- H.M. Shewan and J.R. Stokes, J. Food Eng., 119, 781 (2013); https://doi.org/10.1016/j.jfoodeng.2013.06.046
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J.S. Boateng, K.H. Matthews, H.N.E. Stevens and G.M. Eccleston, J. Pharm. Sci., 97, 2892 (2008); https://doi.org/10.1002/jps.21210
A. Sood, M.S. Granick and N.L. Tomaselli, Adv. Wound Care, 3, 511 (2014); https://doi.org/10.1089/wound.2012.0401
X. Yang, K. Yang, S. Wu, X. Chen, F. Yu, J. Li, M. Ma and Z. Zhu, Radiat. Phys. Chem., 79, 606 (2010); https://doi.org/10.1016/j.radphyschem.2009.12.017
P.T.S. Kumar, S. Abhilash, K. Manzoor, S.V. Nair, H. Tamura and R. Jayakumar, Carbohydr. Polym., 80, 761 (2010); https://doi.org/10.1016/j.carbpol.2009.12.024
J. Zhu and R.E. Marchant, Expert. Rev. Med. Devic., 8, 607 (2011); https://doi.org/10.1586/erd.11.27
A. Chhatri, J. Bajpai and A.K. Bajpai, Biomater., 1, 189 (2011); https://doi.org/10.4161/biom.19005
J. Dutta, Am. J. Chem., 2, 6 (2012); https://doi.org/10.5923/j.chemistry.20120202.02
E.-R. Kenawy, M.H. El-Newehy and S.S. Al-Deyab, J. Saudi Chem. Soc., 14, 237 (2010); https://doi.org/10.1016/j.jscs.2010.02.014
Y. Liu, L.M. Geever, J.E. Kennedy, C.L. Higginbotham, P.A. Cahill and G.B. McGuinness, J. Mech. Behav. Biomed., 3, 203 (2010); https://doi.org/10.1016/j.jmbbm.2009.07.001
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Y. Pounikar, Int J. Pharm. Sci., 4, 85 (2012).
M. Tiwari and M. Upadhayay, J. Med. Plants. Stud., 6, 89 (2018).
P.K. Sahu, D.D. Giri, R. Singh, P. Pandey, S. Gupta, A.K. Shrivastava, A. Kumar and K.D. Pandey, J. Pharm. Pharmacol., 4, 599 (2013); https://doi.org/10.4236/pp.2013.48086
Q. He, L. Changhong, E. Kojo and Z. Tian, Food Control, 16, 95 (2005); https://doi.org/10.1016/j.foodcont.2003.12.001
T. Derbe, B. Yilma and S. Badaca, World J. Pharm. Pharm. Sci., 4, 185 (2015).
S. Alven, X. Nqoro and B.A. Aderibigbe, Polymer, 12, 2286 (2020); https://doi.org/10.3390/polym12102286
V. Vivcharenko and A. Przekora, Appl. Sci., 11, 4114 (2021); https://doi.org/10.3390/app11094114
S.K.H. Gulrez, S. Al-Assaf and G.O. Phillips, Eds.: A. Carpi, Hydrogels: Methods of Preparation, Characterisation and Applications, In: Progress in Molecular and Environmental Bioengineering, IntechOpen, p. 118 (2011).
P.-W. Su, C.-H. Yang, J.-F. Yang, P.-Y. Su and L.-Y. Chuang, Molecules, 20, 11119 (2015); https://doi.org/10.3390/molecules200611119
C. Gambuteanu, D. Borda and P. Alexe, J. Agroaliment. Proc. Technol., 19, 88 (2013).
J.N. Hiremath and B. Vishalakshi, Der Pharma Chem., 4, 946 (2012).
A.M. Young, P.Y. Ng, U. Gbureck, S.N. Nazhat, J.E. Barralet and M.P. Hofmann, Acta Biomater., 4, 1081 (2008); https://doi.org/10.1016/j.actbio.2007.12.009
A. Sharma, S. Bhat, T. Vishnoi, V. Nayak and A. Kumar, BioMed Res. Int., 2013, 478279 (2013); https://doi.org/10.1155/2013/478279
D.T. Padavan, A.M. Hamilton, L.E. Millon, D.R. Boughner and W. Wan, Acta Biomater., 7, 258 (2011); https://doi.org/10.1016/j.actbio.2010.07.038
B. Ghafoor, M.N. Ali, U. Ansari, M.F. Bhatti, H. Mir, H. Akhtar and F. Darakhshan, Int. J. Biomater., 8, 1 (2016); https://doi.org/10.1155/2016/6964938
G. He, H. Zheng and F. Xiong, J. Wuhan Univ. Technol., 23, 816 (2008); https://doi.org/10.1007/s11595-007-6816-1
L.P. Bagri, J. Bajpai and A.K. Bajpai, J. Macromol. Sci. Pure Appl. Chem., 46, 1060 (2009); https://doi.org/10.1080/10601320903252025
T. Çaykara and M. Dogmus, Macromol. Mater. Eng., 289, 548 (2004); https://doi.org/10.1002/mame.200400037
M. Rodriguez-Bigas, N.I. Cruz and A. Suarez, Plast. Reconstr. Surg., 81, 386 (1988); https://doi.org/10.1097/00006534-198803000-00012
H.M. Shewan and J.R. Stokes, J. Food Eng., 119, 781 (2013); https://doi.org/10.1016/j.jfoodeng.2013.06.046