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Vol. 34 No. 8 (2022): Vol 34 Issue 8, 2022

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Antibacterial Investigation and Structural Study on Few ortho-Mercapto-azo Compounds by Spectroscopic Techniques and DFT Calculation

https://doi.org/10.14233/ajchem.2022.23768
Murshida Karim
Department of Chemistry, B.N. College, Dhubri-783324, India
Nizamuddin Ahmed
School of Physical Science, Sherubtse College, Kanglung, Bhutan

Corresponding Author(s) : Murshida Karim

karimmurshida786@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 8 (2022): Vol 34 Issue 8, 2022

Abstract

An efficient method has been applied for the synthesis of bivalent ortho-mercapto-azo compounds by using green reduction, condensation using ionic liquid and green debenzylation. These greener steps provide the benefits like higher yields, shorter reaction times and simple work-up. Density functional theory (DFT) calculation and XRD analysis proved the ionic nature of these compounds as 2-arylbenzo-1-thia-2,3-diazol-2-ium (BTD+) bromide due to intramolecular cyclization between electrophilic sulfur atom and ortho-azo group. Some extent of LUMO orbital is present in electrophilic sulfur atom in BTD+ bromides. These sulfenyl bromides were also found to be active against antibacterial strains.

Keywords

ortho-Mercapto-azo compounds Sulfenyl bromides DFT Antibacterial activity TBATB Iron oxide-hydroxide
Karim, M., & Ahmed, N. (2022). Antibacterial Investigation and Structural Study on Few ortho-Mercapto-azo Compounds by Spectroscopic Techniques and DFT Calculation. Asian Journal of Chemistry, 34(8), 2061–2066. https://doi.org/10.14233/ajchem.2022.23768
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