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Vol. 34 No. 8 (2022): Vol 34 Issue 8, 2022

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Therapeutic Repurposing of Antiviral Drugs Available for COVID-19 Therapy: A Mini Review

https://doi.org/10.14233/ajchem.2022.23819
Nadia Bounoua
Department of Exact Sciences, Normal Higher School of Bechar, Algeria, Laboratory of Chemical and Environmental Science (LCSE), Bechar, Algeria
Khaldun M. Al Azzam
Department of Pharmaceutical Sciences, Pharmacological and Diagnostic Research Center (PDRC), Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan
Hassan Y. Aboul-Enein
Department of Medicinal and Pharmaceutical Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Cairo 12622, Egypt
Mohamed Nadjib Rebizi
Organic Chemistry and Natural Substances Laboratory, Zian Achor University, Djelfa, Algeria
El-Sayed Negim
School of Petroleum Engineering, Satbayev University, 22 Satpayev Street, 050013 Almaty, Kazakhstan

Corresponding Author(s) : Khaldun M. Al Azzam

azzamkha@yahoo.com

Asian Journal of Chemistry, Vol. 34 No. 8 (2022): Vol 34 Issue 8, 2022

Abstract

The impact of repurposing drugs that now in vitro inhibit significant chronic respiratory illness corona virus type 2 was indeed underestimated or ignored during the early phases of the COVID-19 virus. Recent clinical data, however, suggest that remdesivir and favipiravir may hasten to heal, but lopinavir/ritonavir had minimal impact on very ill patients. The interferon appears to be the primary impact of triple therapy with ribavirin, lopinavir and interferon-1b. The role of hydroxychloroquine, marketed as Plaquenil® or chloroquine, marketed as Aralen®, in the treatment and prevention of COVID-19 is presently unknown due to the small sample size research. Anti-cytokine drugs may not benefit persons with mild disease or severe illness. Traditional Chinese medicine (TCM) is commonly used for COVID-19 patients in China and has antiviral and immunomodulatory effects on SARS-CoV-2. This review outlines existing COVID-19 therapeutic options and advocates for clinical trials for children, persons with mild disease and those in the early stages of COVID-19.

Keywords

Antiviral agents Covid-19 therapy Drugs Corona virus Covid-19 disease
Bounoua, N., M. Al Azzam, K., Y. Aboul-Enein, H., Nadjib Rebizi, M., & Negim, E.-S. (2022). Therapeutic Repurposing of Antiviral Drugs Available for COVID-19 Therapy: A Mini Review. Asian Journal of Chemistry, 34(8), 1993–1996. https://doi.org/10.14233/ajchem.2022.23819
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