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Vol. 34 No. 8 (2022): Vol 34 Issue 8, 2022

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Phytochemistry and Pharmacological Properties of Morus alba Linn. with Reference to its SARS-CoV-2 Inhibiting Potential: A Review

https://doi.org/10.14233/ajchem.2022.23891
Shahnaz Alom
Department of Pharmacology, Girijananda Chowdhury Institute of Pharmaceutical Science, Tezpur-784501, India
Farak Ali
Department of Pharmaceutical Chemistry, Girijananda Chowdhury Institute of Pharmaceutical Science, Tezpur-784501, India
Sheikh Rezzak Ali
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786004, India
Abdul Baquee Ahmed
Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Tezpur-784501, India

Corresponding Author(s) : Farak Ali

alifarak347@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 8 (2022): Vol 34 Issue 8, 2022

Abstract

Morus alba Linn. is a plant with varieties of phytochemicals and commonly known as Mulberry tree or Nuni (in Assamese). Mulberry is a perennial and woody plant, belongs to the family Moraceae consider as a native plant of China. In Assam, the leaves of mulberry tree are out most important in horticulture department for feeding purpose. A literature survey was done out by using key words such as Morus alba, or mulberry tree or phytoconstituents, or pharmacological activities, or ethnobotany on the search engine namely Scopus, Web of Science, Google Scholars, PubMed. The purpose of this article is to forward a solid review about the plant profile, method of extraction, phytochemicals constituents and pharmacological activities in reference to SARS-CoV-2. All the parts of Morus alba are phytochemically rich but highest number can be found in fruits and leaves. Fruits of Morus alba contains various class of phytochemicals such as alkaloids, anthocyanins, stillbenoids, flavones. Owing to presence of this compounds, it exhibits various pharmacological. Its leaves, fruits and root bark containing flavonoids, anthocyanins, alkaloids and stilbenoids, possess various pharmacological properties. Resveratrol is one of the most important compounds found in M. alba which possess SARS-CoV-2 inhibiting potential. Still there are some gaps remain in exploring whole plants parts and successive studies of toxicity.

Keywords

Morus alba Mulberry tree SARS-CoV-2 Ethnomedicines Phytochemistry Pharmacological activities
Alom, S., Ali, F., Rezzak Ali, S., & Baquee Ahmed, A. (2022). Phytochemistry and Pharmacological Properties of Morus alba Linn. with Reference to its SARS-CoV-2 Inhibiting Potential: A Review. Asian Journal of Chemistry, 34(8), 1983–1992. https://doi.org/10.14233/ajchem.2022.23891
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References
  1. S.-Y. Pan, G. Litscher, S.-H. Gao, S.-F. Zhou, Z.-L. Yu, H.-Q. Chen, S.-F. Zhang, M.-K. Tang, J.-N. Sun and K.-M. Ko, Evid. Based Complement Alternat. Med., 2014, 525340 (2014); https://doi.org/10.1155/2014/525340
  2. M.S. Butt, A. Nazir, M.T. Sultan and K. Schroën, Trends Food Sci. Technol., 19, 505 (2008); https://doi.org/10.1016/j.tifs.2008.06.002
  3. A. Altemimi, N. Lakhssassi, A. Baharlouei, D.G. Watson and D.A. Lightfoot, Plants, 6, 42 (2017); https://doi.org/10.3390/plants6040042
  4. S. Arabshahi-Delouee and A. Urooj, Food Chem., 102, 1233 (2007); https://doi.org/10.1016/j.foodchem.2006.07.013
  5. E.W.C. Chan, P.Y. Lye and S.K. Wong, Chin. J. Nat. Med., 14, 17 (2016).
  6. H.L. Ramesh, S. Venkataramegowda and V.N.Y. Murthy, World J. Pharm. Res., 3, 320 (2014).
  7. M.S. Zafar, F. Muhammad, I. Javed, M. Akhtar, T. Khaliq, B. Aslam, A. Waheed, R. Yasmin and H. Zafar, Int. J. Agric. Biol., 15, 612 (2013).
  8. V.K. Ramappa, D. Srivastava, P. Singh, U. Kumar, D. Kumar, S.B. Gosipatala, S. Saha, D. Kumar and R. Raj, Int. J. Fruit Sci., 20(Suppl. 3), S1254 (2020); https://doi.org/10.1080/15538362.2020.1784075
  9. S.B. Kim, B.Y. Chang, B.Y. Hwang, S.Y. Kim and M.K. Lee, Bioorg. Med. Chem. Lett., 24, 5656 (2014); https://doi.org/10.1016/j.bmcl.2014.10.073
  10. G. Kusano, S. Orihara, D. Tsukamoto, M. Shibano, M. Coskun, A. Guvenc and C.S. Erdurak, Chem. Pharm. Bull. (Tokyo), 50, 185 (2002); https://doi.org/10.1248/cpb.50.185
  11. M.M. Natic, D. Dabic, A. Papetti, M.M. Fotiric Akšic, V. Ognjanov, M. Ljubojevic and Z.L. Tešic, Food Chem., 171, 128 (2015); https://doi.org/10.1016/j.foodchem.2014.08.101
  12. M.A. Minhas, A. Begum, S. Hamid, M. Babar, R. Ilyas, S. Ali, F. Latif and S. Andleeb, Pak. J. Zool., 48, 1381 (2016).
  13. X. Yang, L. Yang and H. Zheng, Food Chem. Toxicol., 48, 2374 (2010); https://doi.org/10.1016/j.fct.2010.05.074
  14. L. Butkhup, W. Samappito and S. Samappito, Int. J. Food Sci. Technol., 48, 934 (2013); https://doi.org/10.1111/ijfs.12044
  15. Y. Wang, L. Xiang, C. Wang, C. Tang and X. He, PLoS One, 8, e71144 (2013); https://doi.org/10.1371/journal.pone.0071144
  16. P. Aramwit, N. Bang and T. Srichana, Food Res. Int., 43, 1093 (2010); https://doi.org/10.1016/j.foodres.2010.01.022
  17. C. Qin, Y. Li, W. Niu, Y. Ding, R. Zhang and X. Shang, Czech J. Food Sci., 28, 117 (2010); https://doi.org/10.17221/228/2008-CJFS
  18. M. Isabelle, B.L. Lee, C.N. Ong, X. Liu and D. Huang, J. Agric. Food Chem., 56, 9410 (2008); https://doi.org/10.1021/jf801527a
  19. M. Gundogdu, F. Muradoglu, R.I.G. Sensoy and H. Yilmaz, Sci. Hortic., 132, 37 (2011); https://doi.org/10.1016/j.scienta.2011.09.035
  20. A.A. Memon, N. Memon, D.L. Luthria, M.I. Bhanger and A.A. Pitafi, Pol. J. Food Nutr. Sci., 60, 25 (2010).
  21. S.H. Bae and H.J. Suh, Lebensm. Wiss. Technol., 40, 955 (2007); https://doi.org/10.1016/j.lwt.2006.06.007
  22. Q. Yuan and L. Zhao, J. Agric. Food Chem., 65, 10383 (2017); https://doi.org/10.1021/acs.jafc.7b03614
  23. S. Iqbal, U. Younas, K.W. Sirajuddin, K.W. Chan, R.A. Sarfraz and M.K. Uddin, Int. J. Mol. Sci., 13, 6651 (2012); https://doi.org/10.3390/ijms13066651
  24. B. Nickavar and G. Mosazadeh, Iran. J. Pharm. Res., 8, 115 (2009).
  25. S. Priya, J. Nat. Prod. Plant Resour., 2, 440 (2012).
  26. T. Oku, M. Yamada, M. Nakamura, N. Sadamori and S. Nakamura, Br. J. Nutr., 95, 933 (2006); https://doi.org/10.1079/BJN20061746
  27. S.H. Lee, S.Y. Choi, H. Kim, J.S. Hwang, B.G. Lee, J.J. Gao and S.Y. Kim, Biol. Pharm. Bull., 25, 1045 (2002); https://doi.org/10.1248/bpb.25.1045
  28. R. Singh, A. Bagachi, A. Semwell and S. Kaur, J. Med. Plants Res., 7, 461 (2013).
  29. S.J. Aditya Rao, C.K. Ramesh, R. Mahmood and B.T. Prabhakar, Int. J. Pharm. Pharm. Sci., 4, 335 (2012).
  30. A.C. Manjula, Int. J. Curr. Pharm. Res., 3, 13 (2011).
  31. H.Y. Sohn, K.H. Son, C.S. Kwon, G.S. Kwon and S.S. Kang, Phytomedicine, 11, 666 (2004); https://doi.org/10.1016/j.phymed.2003.09.005
  32. T. Nomura, T. Fukai, Y. Hano, S. Yoshizawa, M. Suganuma and H. Fujiki, Prog. Clin. Biol. Res., 280, 267 (1988).
  33. B. Enkhmaa, K. Shiwaku, T. Katsube, K. Kitajima, E. Anuurad, M. Yamasaki and Y. Yamane, J. Nutr., 135, 729 (2005); https://doi.org/10.1093/jn/135.4.729
  34. K. Doi, T. Kojima and Y. Fujimoto, Biol. Pharm. Bull., 23, 1066 (2000); https://doi.org/10.1248/bpb.23.1066
  35. S.U. Chon, Y.M. Kim, Y.J. Park, B.G. Heo, Y.S. Park and S. Gorinstein, Eur. Food Res. Technol., 230, 231 (2009); https://doi.org/10.1007/s00217-009-1165-2
  36. K.-O. Chung, B.-Y. Kim, M.-H. Lee, Y.-R. Kim, H.-Y. Chung, J.-H. Park and J.-O. Moon, J. Pharm. Pharmacol., 55, 1695 (2010); https://doi.org/10.1211/0022357022313
  37. E.M. Choi and J.K. Hwang, Fitoterapia, 76, 608 (2005); https://doi.org/10.1016/j.fitote.2005.05.006
  38. S.P. Jo, J.K. Kim and Y.H. Lim, Food Chem. Toxicol., 65, 213 (2014); https://doi.org/10.1016/j.fct.2013.12.040
  39. H.M. Kim, S.B. Han, K.H. Lee, C.W. Lee, C.Y. Kim, E.J. Lee and H. Huh, Arch. Pharm. Res., 23, 240 (2000); https://doi.org/10.1007/BF02976452
  40. A.L.B. Zeni and M. Dall’Molin, Rev. Bras. Farmacogn., 20, 130 (2010); https://doi.org/10.1590/S0102-695X2010000100025
  41. H.A. El-Beshbishy, A.N.B. Singab, J. Sinkkonen and K. Pihlaja, Life Sci., 78, 2724 (2006); https://doi.org/10.1016/j.lfs.2005.10.010
  42. J. Sattayasai, S. Tiamkao and P. Puapairoj, Phytother. Res., 22, 487 (2008); https://doi.org/10.1002/ptr.2346
  43. J.P. Yadav, S. Saini, A.N. Kalia and A.S. Dangi, Indian J. Pharmacol., 40, 23 (2008); https://doi.org/10.4103/0253-7613.40485
  44. N.P. Seeram, R.A. Momin, M.G. Nair and L.D. Bourquin, Phytomedicine, 8, 362 (2001); https://doi.org/10.1078/0944-7113-00053
  45. T. Niidome, K. Takahashi, Y. Goto, S. Goh, N. Tanaka, K. Kamei, M. Ichida, S. Hara, A. Akaike, T. Kihara and H. Sugimoto, Neuroreport, 18, 813 (2007); https://doi.org/10.1097/WNR.0b013e3280dce5af
  46. M.G. Hogade, K.S. Patil, G.H. Wadkar, S.S. Mathapati and P.B. Dhumal, Afr. J. Pharm. Pharmacol., 4, 731 (2010).
  47. H. Kalantari, N. Aghel and M. Bayati, Saudi Pharm. J., 17, 90 (2009).
  48. M. Nematbakhsh, V. Hajhashemi, A. Ghannadi, A. Talebi and M. Nikahd, Res. Pharm. Sci., 8, 71 (2013).
  49. H. Kim and M.S. Chung, Evidence-Based Complement. Altern. Med., 2018, 2606583 (2018); https://doi.org/10.1155/2018/2606583
  50. P.I. Manzano-Santana, J.P. Peñarreta-Tivillin, I.A. Chóez-Guaranda, A.D. Barragán-Lucas, A.K. Orellana-Manzano and L. Rastrelli, Rev. Bionatura, 6, 1653 (2021); https://doi.org/10.21931/RB/2021.06.01.30
  51. I. Thabti, Q. Albert, S. Philippot, F. Dupire, B. Westerhuis, S. Fontanay, A. Risler, T. Kassab, W. Elfalleh, A. Aferchichi and M. Varbanov, Molecules, 25, 1876 (2020); https://doi.org/10.3390/molecules25081876
  52. M. Omrani, M. Keshavarz, S.N. Ebrahimi, M. Mehrabi, L.J. McGaw, M.A. Abdalla and P. Mehrbod, Front. Pharmacol., 11, 586993 (2021); https://doi.org/10.3389/fphar.2020.586993
  53. A. Shakya, R. V. Chikhale, H.R. Bhat, F.A. Alasmary, T.M. Almutairi, S.K. Ghosh, H.M. Alhajri, S.A. Alissa, S. Nagar and M.A. Islam, Mol. Divers., 26, 265 (2022); https://doi.org/10.1007/s11030-021-10209-3
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