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Vol. 34 No. 7 (2022): Vol 34 Issue 7, 2022

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Synthesis, Characterization and Molecular Docking Studies of 5-Chloro-1-(1H-indole-2-yl)-3-methyl-4,5-dihydro-1H-pyrazole-4-carboxylic Acids

https://doi.org/10.14233/ajchem.2022.23610
G. Ganga Reddy
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, India
S. Ramakrishna Reddy
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, India
Ch. Venkata Ramana Reddy
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, India
E. Laxminarayana
Sreenidhi Institute of Science and Technology (Autonomous) Yamnampet, Ghatkesar, Hyderabad-501301, India
B. Srinivasa Reddy
Department of Chemistry, Mahatma Gandhi Institute of Technology, Kokapet, Gandipet, Hyderabad-500075, India

Corresponding Author(s) : B. Srinivasa Reddy

srinivasjntu123@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 7 (2022): Vol 34 Issue 7, 2022

Abstract

A series of new 5-chloro-1-(1H-indole-2-yl)-3-methyl-4,5-dihydro-1H-pyrazole-4-carbxylic acids (5a-c) was synthesized. For the synthesis of these compounds, the 1H-indole-2-carboxylic acids (1a-c) were used as core compound. The synthetic route leading to the title compounds is summarized in Scheme-I. The chemical structures of all intermediates and products were confirmed by their IR, 1H and 13C NMR, mass spectral data and elemental analysis. The molecular docking studies of title compounds was carried out to predict the binding interactions with target protein EGFR.

Keywords

Vilsmeier-Hack formylation Indoles Pyrazoles Docking studies
Ganga Reddy, G., Ramakrishna Reddy, S., Venkata Ramana Reddy, C., Laxminarayana, E., & Srinivasa Reddy, B. (2022). Synthesis, Characterization and Molecular Docking Studies of 5-Chloro-1-(1H-indole-2-yl)-3-methyl-4,5-dihydro-1H-pyrazole-4-carboxylic Acids. Asian Journal of Chemistry, 34(7), 1639–1643. https://doi.org/10.14233/ajchem.2022.23610
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