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Vol. 31 No. 6 (2019): Vol 31 Issue 6

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Synthesis, Anti-inflammatory, Analgesic and Antipyretic Activity of Novel 1,3,5-Trisubstituted Pyrazole Derivatives

https://doi.org/10.14233/ajchem.2019.21781
Thatavarthi Padmini
Department of Chemistry, Mewar University, Chittorgarh-312901, India
Bigala Raj Kamal
Department of Chemistry, Mewar University, Chittorgarh-312901, India

Corresponding Author(s) : Thatavarthi Padmini

thatap@yahoo.com

Asian Journal of Chemistry, Vol. 31 No. 6 (2019): Vol 31 Issue 6

Abstract

A novel series of 1,3,5-trisubstituted pyrazole derivatives were synthesized by the cycloaddition reaction between the electron rich N-substituted aryl hydrazones and nitro-olefins. Different N-substituted aryl hydrazones (1a-j) on reacting with 4-methyl-β-nitrostyrene (2) in ethylene glycol or trifluoroethanoltrifluoro acetic acid mixture (for acid stable hydrazones) at 120 ºC, yielded various 1,3,5-trisubstituted pyrazoles (3a-j). The final products were characterized by spectral analysis using Mass, NMR and IR spectroscopy. All the products were assessed for their anti-inflammatory, analgesic and antipyretic activities on Swiss albino rats. All the compounds (3a-j) exhibited noteworthy defence against inflammation, nociception and hyperthermia. Compounds (3e and 3h) disclosed better anti-inflammatory, analgesic and antipyretic activities while compound 3c had highest anti-inflammatory activity compared to the standard nimesulide.

Keywords

Cycloaddition Nitro olefins Hydrazones Anti-inflammatory Analgesic Antipyretic
Padmini, T., & Kamal, B. R. (2019). Synthesis, Anti-inflammatory, Analgesic and Antipyretic Activity of Novel 1,3,5-Trisubstituted Pyrazole Derivatives. Asian Journal of Chemistry, 31(6), 1225–1229. https://doi.org/10.14233/ajchem.2019.21781
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