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Vol. 34 No. 6 (2022): Vol 34 Issue 6

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One-Pot Green Synthesis of Pyridine-2-carbaldehyde based Chalcones under Solvent-Free Condition using Mesoporous MCM-41 Materials and their Antimicrobial Activities

https://doi.org/10.14233/ajchem.2022.23687
Jayarangarao Prathipati
Department of Chemistry, Baba Institute of Technology & Sciences (BITS), Visakhapatnam-530041, India
Paul Douglas Sanasi
Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530003, India

Corresponding Author(s) : Jayarangarao Prathipati

jayarangarao1@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 6 (2022): Vol 34 Issue 6

Abstract

A simplistic one-pot synthetic protocol was performed using aromatic ketones (1a-e) and substituted pyridine-2-carbaldehydes (2a-e) to obtain various substituted chalcones (3a-e). The synthesis was catalyzed by various metal incorporated (Mn, Al) and acid functionalized (H2SO4, H3PW12O40) mesoporous MCM-41 materials, under solvent free conditions. Using pyridine-2-carbaldehyde (2a), its analogs viz., 4-methoxy (2b), 4-chloro (2c), 4-hydroxy (2d) and 4-nitro (2e) pyridine-2-carbaldehydes were synthesized separately, in order to use these precursors for the formation of the organic derivatives 3b to 3e. Their structural features were characterized by using 1H NMR, 13C NMR and mass spectral techniques. Both the acid functionalized MCM-41 were almost equal in their catalytic performance, whereas among the Mn+-MCM-41 [Mn+ = Mn/Al], the Al incorporated material has shown slightly higher catalytic performance. The antimicrobial activities of the derivatives (3a-e), was investigated on the selected microorganisms, using standard procedures. In these studies, except the compound 3e, remaining compounds have displayed superior biological activity.

Keywords

One-pot synthesis Chalcones Mesoporous silica Solvent free conditions Antibacterial activity Antifungal activity
Prathipati, J., & Douglas Sanasi, P. (2022). One-Pot Green Synthesis of Pyridine-2-carbaldehyde based Chalcones under Solvent-Free Condition using Mesoporous MCM-41 Materials and their Antimicrobial Activities. Asian Journal of Chemistry, 34(6), 1498–1504. https://doi.org/10.14233/ajchem.2022.23687
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